Actin filaments-A target for redox regulation

Autores
Wilson Rodriguez, Carlos; Terman, Jonathan R.; González Billault, Christian; Ahmed, Giasuddin
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Actin and its ability to polymerize into dynamic filaments is critical for the form and function of cells throughout the body. While multiple proteins have been characterized as affecting actin dynamics through noncovalent means, actin and its protein regulators are also susceptible to covalent modifications of their amino acid residues. In this regard, oxidation-reduction (Redox) intermediates have emerged as key modulators of the actin cytoskeleton with multiple different effects on cellular form and function. Here, we review work implicating Redox intermediates in post-translationally altering actin and discuss what is known regarding how these alterations affect the properties of actin. We also focus on two of the best characterized enzymatic sources of these Redox intermediates—the NADPH oxidase NOX and the flavoprotein monooxygenase MICAL—and detail how they have both been identified as altering actin, but share little similarity and employ different means to regulate actin dynamics. Finally, we discuss the role of these enzymes and redox signaling in regulating the actin cytoskeleton in vivo and highlight their importance for neuronal form and function in health and disease. © 2016 Wiley Periodicals, Inc.
Fil: Wilson Rodriguez, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Chile; Chile. Center for Geroscience; Chile
Fil: Terman, Jonathan R.. The University of Texas Southwestern; Estados Unidos
Fil: González Billault, Christian. Universidad de Chile; Chile. Center for Geroscience; Chile. The Buck Institute for Research on Aging; Estados Unidos
Fil: Ahmed, Giasuddin. The University of Texas Southwestern; Estados Unidos
Materia
ACTIN
MICAL
NADPH OXIDASE
POST-TRANSLATIONAL MODIFICATION
REDOX
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/72246
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/72246
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Actin filaments-A target for redox regulationWilson Rodriguez, CarlosTerman, Jonathan R.González Billault, ChristianAhmed, GiasuddinACTINMICALNADPH OXIDASEPOST-TRANSLATIONAL MODIFICATIONREDOXhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Actin and its ability to polymerize into dynamic filaments is critical for the form and function of cells throughout the body. While multiple proteins have been characterized as affecting actin dynamics through noncovalent means, actin and its protein regulators are also susceptible to covalent modifications of their amino acid residues. In this regard, oxidation-reduction (Redox) intermediates have emerged as key modulators of the actin cytoskeleton with multiple different effects on cellular form and function. Here, we review work implicating Redox intermediates in post-translationally altering actin and discuss what is known regarding how these alterations affect the properties of actin. We also focus on two of the best characterized enzymatic sources of these Redox intermediates—the NADPH oxidase NOX and the flavoprotein monooxygenase MICAL—and detail how they have both been identified as altering actin, but share little similarity and employ different means to regulate actin dynamics. Finally, we discuss the role of these enzymes and redox signaling in regulating the actin cytoskeleton in vivo and highlight their importance for neuronal form and function in health and disease. © 2016 Wiley Periodicals, Inc.Fil: Wilson Rodriguez, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Chile; Chile. Center for Geroscience; ChileFil: Terman, Jonathan R.. The University of Texas Southwestern; Estados UnidosFil: González Billault, Christian. Universidad de Chile; Chile. Center for Geroscience; Chile. The Buck Institute for Research on Aging; Estados UnidosFil: Ahmed, Giasuddin. The University of Texas Southwestern; Estados UnidosJohn Wiley and Sons Inc.2016-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/72246Wilson Rodriguez, Carlos; Terman, Jonathan R.; González Billault, Christian; Ahmed, Giasuddin; Actin filaments-A target for redox regulation; John Wiley and Sons Inc.; Cytoskeleton; 73; 10; 10-2016; 577-5951949-3592CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/cm.21315info:eu-repo/semantics/altIdentifier/doi/10.1002/cm.21315info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:10Zoai:ri.conicet.gov.ar:11336/72246instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:11.19CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Actin filaments-A target for redox regulation
title Actin filaments-A target for redox regulation
spellingShingle Actin filaments-A target for redox regulation
Wilson Rodriguez, Carlos
ACTIN
MICAL
NADPH OXIDASE
POST-TRANSLATIONAL MODIFICATION
REDOX
title_short Actin filaments-A target for redox regulation
title_full Actin filaments-A target for redox regulation
title_fullStr Actin filaments-A target for redox regulation
title_full_unstemmed Actin filaments-A target for redox regulation
title_sort Actin filaments-A target for redox regulation
dc.creator.none.fl_str_mv Wilson Rodriguez, Carlos
Terman, Jonathan R.
González Billault, Christian
Ahmed, Giasuddin
author Wilson Rodriguez, Carlos
author_facet Wilson Rodriguez, Carlos
Terman, Jonathan R.
González Billault, Christian
Ahmed, Giasuddin
author_role author
author2 Terman, Jonathan R.
González Billault, Christian
Ahmed, Giasuddin
author2_role author
author
author
dc.subject.none.fl_str_mv ACTIN
MICAL
NADPH OXIDASE
POST-TRANSLATIONAL MODIFICATION
REDOX
topic ACTIN
MICAL
NADPH OXIDASE
POST-TRANSLATIONAL MODIFICATION
REDOX
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Actin and its ability to polymerize into dynamic filaments is critical for the form and function of cells throughout the body. While multiple proteins have been characterized as affecting actin dynamics through noncovalent means, actin and its protein regulators are also susceptible to covalent modifications of their amino acid residues. In this regard, oxidation-reduction (Redox) intermediates have emerged as key modulators of the actin cytoskeleton with multiple different effects on cellular form and function. Here, we review work implicating Redox intermediates in post-translationally altering actin and discuss what is known regarding how these alterations affect the properties of actin. We also focus on two of the best characterized enzymatic sources of these Redox intermediates—the NADPH oxidase NOX and the flavoprotein monooxygenase MICAL—and detail how they have both been identified as altering actin, but share little similarity and employ different means to regulate actin dynamics. Finally, we discuss the role of these enzymes and redox signaling in regulating the actin cytoskeleton in vivo and highlight their importance for neuronal form and function in health and disease. © 2016 Wiley Periodicals, Inc.
Fil: Wilson Rodriguez, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Chile; Chile. Center for Geroscience; Chile
Fil: Terman, Jonathan R.. The University of Texas Southwestern; Estados Unidos
Fil: González Billault, Christian. Universidad de Chile; Chile. Center for Geroscience; Chile. The Buck Institute for Research on Aging; Estados Unidos
Fil: Ahmed, Giasuddin. The University of Texas Southwestern; Estados Unidos
description Actin and its ability to polymerize into dynamic filaments is critical for the form and function of cells throughout the body. While multiple proteins have been characterized as affecting actin dynamics through noncovalent means, actin and its protein regulators are also susceptible to covalent modifications of their amino acid residues. In this regard, oxidation-reduction (Redox) intermediates have emerged as key modulators of the actin cytoskeleton with multiple different effects on cellular form and function. Here, we review work implicating Redox intermediates in post-translationally altering actin and discuss what is known regarding how these alterations affect the properties of actin. We also focus on two of the best characterized enzymatic sources of these Redox intermediates—the NADPH oxidase NOX and the flavoprotein monooxygenase MICAL—and detail how they have both been identified as altering actin, but share little similarity and employ different means to regulate actin dynamics. Finally, we discuss the role of these enzymes and redox signaling in regulating the actin cytoskeleton in vivo and highlight their importance for neuronal form and function in health and disease. © 2016 Wiley Periodicals, Inc.
publishDate 2016
dc.date.none.fl_str_mv 2016-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/72246
Wilson Rodriguez, Carlos; Terman, Jonathan R.; González Billault, Christian; Ahmed, Giasuddin; Actin filaments-A target for redox regulation; John Wiley and Sons Inc.; Cytoskeleton; 73; 10; 10-2016; 577-595
1949-3592
CONICET Digital
CONICET
url http://hdl.handle.net/11336/72246
identifier_str_mv Wilson Rodriguez, Carlos; Terman, Jonathan R.; González Billault, Christian; Ahmed, Giasuddin; Actin filaments-A target for redox regulation; John Wiley and Sons Inc.; Cytoskeleton; 73; 10; 10-2016; 577-595
1949-3592
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/cm.21315
info:eu-repo/semantics/altIdentifier/doi/10.1002/cm.21315
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley and Sons Inc.
publisher.none.fl_str_mv John Wiley and Sons Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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