Progesterone receptors in normal breast development and breast cancer

Autores
Giulianelli, Sebastian Jesus; Lamb, Caroline Ana; Lanari, Claudia Lee Malvina
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has led to the development and study of different progestins and antiprogestins, many of which are currently being tested in clinical trials for cancer treatment. Recent reviews have addressed the role of PR in MG development, carcinogenesis, and breast cancer growth. Thus, in this review, in addition to making an overview on PR action in normal and tumor breast, the focus has been put on highlighting the still unresolved topics on hormone treatment involving PR isoforms and breast cancer prognosis.
Fil: Giulianelli, Sebastian Jesus. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
BREAST CANCER
PROGESTERONE RECEPTORS
NORMAL BREAST
PROGESTINS
ANTIPROGESTINS
ENDOCRINE THERAPIES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/140025
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Progesterone receptors in normal breast development and breast cancerGiulianelli, Sebastian JesusLamb, Caroline AnaLanari, Claudia Lee MalvinaBREAST CANCERPROGESTERONE RECEPTORSNORMAL BREASTPROGESTINSANTIPROGESTINSENDOCRINE THERAPIEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has led to the development and study of different progestins and antiprogestins, many of which are currently being tested in clinical trials for cancer treatment. Recent reviews have addressed the role of PR in MG development, carcinogenesis, and breast cancer growth. Thus, in this review, in addition to making an overview on PR action in normal and tumor breast, the focus has been put on highlighting the still unresolved topics on hormone treatment involving PR isoforms and breast cancer prognosis.Fil: Giulianelli, Sebastian Jesus. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaPortland Press2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/140025Giulianelli, Sebastian Jesus; Lamb, Caroline Ana; Lanari, Claudia Lee Malvina; Progesterone receptors in normal breast development and breast cancer; Portland Press; Essays In Biochemistry; 6-20210071-13651744-1358CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://portlandpress.com/essaysbiochem/article/doi/10.1042/EBC20200163/228842/Progesterone-receptors-in-normal-breastinfo:eu-repo/semantics/altIdentifier/doi/10.1042/EBC20200163info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:15Zoai:ri.conicet.gov.ar:11336/140025instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:15.949CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Progesterone receptors in normal breast development and breast cancer
title Progesterone receptors in normal breast development and breast cancer
spellingShingle Progesterone receptors in normal breast development and breast cancer
Giulianelli, Sebastian Jesus
BREAST CANCER
PROGESTERONE RECEPTORS
NORMAL BREAST
PROGESTINS
ANTIPROGESTINS
ENDOCRINE THERAPIES
title_short Progesterone receptors in normal breast development and breast cancer
title_full Progesterone receptors in normal breast development and breast cancer
title_fullStr Progesterone receptors in normal breast development and breast cancer
title_full_unstemmed Progesterone receptors in normal breast development and breast cancer
title_sort Progesterone receptors in normal breast development and breast cancer
dc.creator.none.fl_str_mv Giulianelli, Sebastian Jesus
Lamb, Caroline Ana
Lanari, Claudia Lee Malvina
author Giulianelli, Sebastian Jesus
author_facet Giulianelli, Sebastian Jesus
Lamb, Caroline Ana
Lanari, Claudia Lee Malvina
author_role author
author2 Lamb, Caroline Ana
Lanari, Claudia Lee Malvina
author2_role author
author
dc.subject.none.fl_str_mv BREAST CANCER
PROGESTERONE RECEPTORS
NORMAL BREAST
PROGESTINS
ANTIPROGESTINS
ENDOCRINE THERAPIES
topic BREAST CANCER
PROGESTERONE RECEPTORS
NORMAL BREAST
PROGESTINS
ANTIPROGESTINS
ENDOCRINE THERAPIES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has led to the development and study of different progestins and antiprogestins, many of which are currently being tested in clinical trials for cancer treatment. Recent reviews have addressed the role of PR in MG development, carcinogenesis, and breast cancer growth. Thus, in this review, in addition to making an overview on PR action in normal and tumor breast, the focus has been put on highlighting the still unresolved topics on hormone treatment involving PR isoforms and breast cancer prognosis.
Fil: Giulianelli, Sebastian Jesus. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina
Fil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has led to the development and study of different progestins and antiprogestins, many of which are currently being tested in clinical trials for cancer treatment. Recent reviews have addressed the role of PR in MG development, carcinogenesis, and breast cancer growth. Thus, in this review, in addition to making an overview on PR action in normal and tumor breast, the focus has been put on highlighting the still unresolved topics on hormone treatment involving PR isoforms and breast cancer prognosis.
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/140025
Giulianelli, Sebastian Jesus; Lamb, Caroline Ana; Lanari, Claudia Lee Malvina; Progesterone receptors in normal breast development and breast cancer; Portland Press; Essays In Biochemistry; 6-2021
0071-1365
1744-1358
CONICET Digital
CONICET
url http://hdl.handle.net/11336/140025
identifier_str_mv Giulianelli, Sebastian Jesus; Lamb, Caroline Ana; Lanari, Claudia Lee Malvina; Progesterone receptors in normal breast development and breast cancer; Portland Press; Essays In Biochemistry; 6-2021
0071-1365
1744-1358
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://portlandpress.com/essaysbiochem/article/doi/10.1042/EBC20200163/228842/Progesterone-receptors-in-normal-breast
info:eu-repo/semantics/altIdentifier/doi/10.1042/EBC20200163
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Portland Press
publisher.none.fl_str_mv Portland Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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