DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins

Autores
Navarro, Alvaro Martin; Orti, Fernando Ezequiel; Martinez Perez, Elizabeth; Alonso, Macarena; Simonetti, Franco Lucio; Iserte, Javier Alonso; Marino Buslje, Cristina
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Motivation: Proteins involved in liquid–liquid phase separation (LLPS) and membraneless organelles (MLOs) are recognized to be decisive for many biological processes and also responsible for several diseases. The recent explosion of research in the area still lacks tools for the analysis and data integration among different repositories. Currently, there is not a comprehensive and dedicated database that collects all disease-related variations in combination with the protein location, biological role in the MLO, and all the metadata available for each protein and disease. Disease-related protein variants and additional features are dispersed and the user has to navigate many databases, with a different focus, formats, and often not user friendly. Results: We present DisPhaseDB, a database dedicated to disease-related variants of liquid–liquid phase separation proteins. It integrates 10 databases, contains 5,741 proteins, 1,660,059 variants, and 4,051 disease terms. It also offers intuitive navigation and an informative display. It constitutes a pivotal starting point for further analysis, encouraging the development of new computational tools. The database is freely available at http://disphasedb.leloir.org.ar.
Fil: Navarro, Alvaro Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Orti, Fernando Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Martinez Perez, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Alonso, Macarena. Fundación Instituto Leloir; Argentina
Fil: Simonetti, Franco Lucio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Iserte, Javier Alonso. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Marino Buslje, Cristina. Fundación Instituto Leloir; Argentina
Materia
DATABASE
DISEASE VARIATIONS
DISEASES
LIQUID–LIQUID PHASE SEPARATION PROTEINS
LLPS
MEMBRANE-LESS ORGANELLES
MLO
WEB SERVER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/216120
Acceder
id CONICETDig_04444362d4481f637dc5b9fa6b8ff71c
oai_identifier_str oai:ri.conicet.gov.ar:11336/216120
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteinsNavarro, Alvaro MartinOrti, Fernando EzequielMartinez Perez, ElizabethAlonso, MacarenaSimonetti, Franco LucioIserte, Javier AlonsoMarino Buslje, CristinaDATABASEDISEASE VARIATIONSDISEASESLIQUID–LIQUID PHASE SEPARATION PROTEINSLLPSMEMBRANE-LESS ORGANELLESMLOWEB SERVERhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Motivation: Proteins involved in liquid–liquid phase separation (LLPS) and membraneless organelles (MLOs) are recognized to be decisive for many biological processes and also responsible for several diseases. The recent explosion of research in the area still lacks tools for the analysis and data integration among different repositories. Currently, there is not a comprehensive and dedicated database that collects all disease-related variations in combination with the protein location, biological role in the MLO, and all the metadata available for each protein and disease. Disease-related protein variants and additional features are dispersed and the user has to navigate many databases, with a different focus, formats, and often not user friendly. Results: We present DisPhaseDB, a database dedicated to disease-related variants of liquid–liquid phase separation proteins. It integrates 10 databases, contains 5,741 proteins, 1,660,059 variants, and 4,051 disease terms. It also offers intuitive navigation and an informative display. It constitutes a pivotal starting point for further analysis, encouraging the development of new computational tools. The database is freely available at http://disphasedb.leloir.org.ar.Fil: Navarro, Alvaro Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Orti, Fernando Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Martinez Perez, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Alonso, Macarena. Fundación Instituto Leloir; ArgentinaFil: Simonetti, Franco Lucio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Iserte, Javier Alonso. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Marino Buslje, Cristina. Fundación Instituto Leloir; ArgentinaElsevier2022-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216120Navarro, Alvaro Martin; Orti, Fernando Ezequiel; Martinez Perez, Elizabeth; Alonso, Macarena; Simonetti, Franco Lucio; et al.; DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins; Elsevier; Computational and Structural Biotechnology Journal; 20; 1-2022; 2551-25572001-0370CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S200103702200160Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.csbj.2022.05.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:51:08Zoai:ri.conicet.gov.ar:11336/216120instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:51:09.04CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins
title DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins
spellingShingle DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins
Navarro, Alvaro Martin
DATABASE
DISEASE VARIATIONS
DISEASES
LIQUID–LIQUID PHASE SEPARATION PROTEINS
LLPS
MEMBRANE-LESS ORGANELLES
MLO
WEB SERVER
title_short DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins
title_full DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins
title_fullStr DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins
title_full_unstemmed DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins
title_sort DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins
dc.creator.none.fl_str_mv Navarro, Alvaro Martin
Orti, Fernando Ezequiel
Martinez Perez, Elizabeth
Alonso, Macarena
Simonetti, Franco Lucio
Iserte, Javier Alonso
Marino Buslje, Cristina
author Navarro, Alvaro Martin
author_facet Navarro, Alvaro Martin
Orti, Fernando Ezequiel
Martinez Perez, Elizabeth
Alonso, Macarena
Simonetti, Franco Lucio
Iserte, Javier Alonso
Marino Buslje, Cristina
author_role author
author2 Orti, Fernando Ezequiel
Martinez Perez, Elizabeth
Alonso, Macarena
Simonetti, Franco Lucio
Iserte, Javier Alonso
Marino Buslje, Cristina
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv DATABASE
DISEASE VARIATIONS
DISEASES
LIQUID–LIQUID PHASE SEPARATION PROTEINS
LLPS
MEMBRANE-LESS ORGANELLES
MLO
WEB SERVER
topic DATABASE
DISEASE VARIATIONS
DISEASES
LIQUID–LIQUID PHASE SEPARATION PROTEINS
LLPS
MEMBRANE-LESS ORGANELLES
MLO
WEB SERVER
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Motivation: Proteins involved in liquid–liquid phase separation (LLPS) and membraneless organelles (MLOs) are recognized to be decisive for many biological processes and also responsible for several diseases. The recent explosion of research in the area still lacks tools for the analysis and data integration among different repositories. Currently, there is not a comprehensive and dedicated database that collects all disease-related variations in combination with the protein location, biological role in the MLO, and all the metadata available for each protein and disease. Disease-related protein variants and additional features are dispersed and the user has to navigate many databases, with a different focus, formats, and often not user friendly. Results: We present DisPhaseDB, a database dedicated to disease-related variants of liquid–liquid phase separation proteins. It integrates 10 databases, contains 5,741 proteins, 1,660,059 variants, and 4,051 disease terms. It also offers intuitive navigation and an informative display. It constitutes a pivotal starting point for further analysis, encouraging the development of new computational tools. The database is freely available at http://disphasedb.leloir.org.ar.
Fil: Navarro, Alvaro Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Orti, Fernando Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Martinez Perez, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Alonso, Macarena. Fundación Instituto Leloir; Argentina
Fil: Simonetti, Franco Lucio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Iserte, Javier Alonso. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Marino Buslje, Cristina. Fundación Instituto Leloir; Argentina
description Motivation: Proteins involved in liquid–liquid phase separation (LLPS) and membraneless organelles (MLOs) are recognized to be decisive for many biological processes and also responsible for several diseases. The recent explosion of research in the area still lacks tools for the analysis and data integration among different repositories. Currently, there is not a comprehensive and dedicated database that collects all disease-related variations in combination with the protein location, biological role in the MLO, and all the metadata available for each protein and disease. Disease-related protein variants and additional features are dispersed and the user has to navigate many databases, with a different focus, formats, and often not user friendly. Results: We present DisPhaseDB, a database dedicated to disease-related variants of liquid–liquid phase separation proteins. It integrates 10 databases, contains 5,741 proteins, 1,660,059 variants, and 4,051 disease terms. It also offers intuitive navigation and an informative display. It constitutes a pivotal starting point for further analysis, encouraging the development of new computational tools. The database is freely available at http://disphasedb.leloir.org.ar.
publishDate 2022
dc.date.none.fl_str_mv 2022-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216120
Navarro, Alvaro Martin; Orti, Fernando Ezequiel; Martinez Perez, Elizabeth; Alonso, Macarena; Simonetti, Franco Lucio; et al.; DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins; Elsevier; Computational and Structural Biotechnology Journal; 20; 1-2022; 2551-2557
2001-0370
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216120
identifier_str_mv Navarro, Alvaro Martin; Orti, Fernando Ezequiel; Martinez Perez, Elizabeth; Alonso, Macarena; Simonetti, Franco Lucio; et al.; DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins; Elsevier; Computational and Structural Biotechnology Journal; 20; 1-2022; 2551-2557
2001-0370
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S200103702200160X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.csbj.2022.05.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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