Whole genome analysis of the action of interferon-β

Autores
Kauffman, Marcelo Andres; Yankilevich, Patricio; Barrero, Paola Roxana; Ricardo Bello; Marangunich, L.; Vidal, A.; Criscuolo, M.; Diez, Roberto Alejandro; Sterin Prync, Aída Edith
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: To characterize the IFN1a-regulated gene expression on leukocytes of Multiple Sclerosis (MS) patients using microarrays with whole human genome representation. Methods: Genes differentially expressed by interferon- were identified by a microarray in vitro study performed in leukocytes obtained from 5MS relapsing-remitting patients. Results: Following the culture of peripheral blood mononuclear cells from MS relapsing-remitting patients for 24 hs with IFN1a, the expression of 868 genes was modified: 545 increased (including CXCL11, CCL8, INDO, IFI27, CFB, CXCL10 and IFIT1) and 323 diminished (including RBP7, SEPT5, RNF8, ADORA2B and FOS). Conclusions: Since many of them were previously recognized as involved in MS pathogenesis, the IFNb1a mechanism of action could imply a compensatory regulation of systems deregulated in MS.
Fil: Kauffman, Marcelo Andres. Biosidus S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Yankilevich, Patricio. Biosidus S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barrero, Paola Roxana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ricardo Bello. Biosidus S. A.; Argentina
Fil: Marangunich, L.. Biosidus S. A.; Argentina
Fil: Vidal, A.. Biosidus S. A.; Argentina
Fil: Criscuolo, M.. Biosidus S. A.; Argentina
Fil: Diez, Roberto Alejandro. Biosidus S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sterin Prync, Aída Edith. Biosidus S. A.; Argentina
Materia
GENOMICS
INTERFERON-Β
MICROARRAY
MULTIPLE SCLEROSIS
TREATMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/148228
Acceder
id CONICETDig_03ef3fe996435269f193bd3b59322a21
oai_identifier_str oai:ri.conicet.gov.ar:11336/148228
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Whole genome analysis of the action of interferon-βKauffman, Marcelo AndresYankilevich, PatricioBarrero, Paola RoxanaRicardo BelloMarangunich, L.Vidal, A.Criscuolo, M.Diez, Roberto AlejandroSterin Prync, Aída EdithGENOMICSINTERFERON-ΒMICROARRAYMULTIPLE SCLEROSISTREATMENThttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Objectives: To characterize the IFN1a-regulated gene expression on leukocytes of Multiple Sclerosis (MS) patients using microarrays with whole human genome representation. Methods: Genes differentially expressed by interferon- were identified by a microarray in vitro study performed in leukocytes obtained from 5MS relapsing-remitting patients. Results: Following the culture of peripheral blood mononuclear cells from MS relapsing-remitting patients for 24 hs with IFN1a, the expression of 868 genes was modified: 545 increased (including CXCL11, CCL8, INDO, IFI27, CFB, CXCL10 and IFIT1) and 323 diminished (including RBP7, SEPT5, RNF8, ADORA2B and FOS). Conclusions: Since many of them were previously recognized as involved in MS pathogenesis, the IFNb1a mechanism of action could imply a compensatory regulation of systems deregulated in MS.Fil: Kauffman, Marcelo Andres. Biosidus S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Yankilevich, Patricio. Biosidus S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barrero, Paola Roxana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ricardo Bello. Biosidus S. A.; ArgentinaFil: Marangunich, L.. Biosidus S. A.; ArgentinaFil: Vidal, A.. Biosidus S. A.; ArgentinaFil: Criscuolo, M.. Biosidus S. A.; ArgentinaFil: Diez, Roberto Alejandro. Biosidus S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sterin Prync, Aída Edith. Biosidus S. A.; ArgentinaDustri-Verlag Dr. Karl Feistle2009-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/148228Kauffman, Marcelo Andres; Yankilevich, Patricio; Barrero, Paola Roxana; Ricardo Bello; Marangunich, L.; et al.; Whole genome analysis of the action of interferon-β; Dustri-Verlag Dr. Karl Feistle; International Journal of Clinical Pharmacology and Therapeutics; 47; 5; 5-2009; 328-3570946-1965CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.dustri.com/article_response_page.html?artId=5980&doi=10.5414/CPP47328&L=0info:eu-repo/semantics/altIdentifier/doi/10.5414/CPP47328info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:32Zoai:ri.conicet.gov.ar:11336/148228instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:33.215CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Whole genome analysis of the action of interferon-β
title Whole genome analysis of the action of interferon-β
spellingShingle Whole genome analysis of the action of interferon-β
Kauffman, Marcelo Andres
GENOMICS
INTERFERON-Β
MICROARRAY
MULTIPLE SCLEROSIS
TREATMENT
title_short Whole genome analysis of the action of interferon-β
title_full Whole genome analysis of the action of interferon-β
title_fullStr Whole genome analysis of the action of interferon-β
title_full_unstemmed Whole genome analysis of the action of interferon-β
title_sort Whole genome analysis of the action of interferon-β
dc.creator.none.fl_str_mv Kauffman, Marcelo Andres
Yankilevich, Patricio
Barrero, Paola Roxana
Ricardo Bello
Marangunich, L.
Vidal, A.
Criscuolo, M.
Diez, Roberto Alejandro
Sterin Prync, Aída Edith
author Kauffman, Marcelo Andres
author_facet Kauffman, Marcelo Andres
Yankilevich, Patricio
Barrero, Paola Roxana
Ricardo Bello
Marangunich, L.
Vidal, A.
Criscuolo, M.
Diez, Roberto Alejandro
Sterin Prync, Aída Edith
author_role author
author2 Yankilevich, Patricio
Barrero, Paola Roxana
Ricardo Bello
Marangunich, L.
Vidal, A.
Criscuolo, M.
Diez, Roberto Alejandro
Sterin Prync, Aída Edith
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv GENOMICS
INTERFERON-Β
MICROARRAY
MULTIPLE SCLEROSIS
TREATMENT
topic GENOMICS
INTERFERON-Β
MICROARRAY
MULTIPLE SCLEROSIS
TREATMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: To characterize the IFN1a-regulated gene expression on leukocytes of Multiple Sclerosis (MS) patients using microarrays with whole human genome representation. Methods: Genes differentially expressed by interferon- were identified by a microarray in vitro study performed in leukocytes obtained from 5MS relapsing-remitting patients. Results: Following the culture of peripheral blood mononuclear cells from MS relapsing-remitting patients for 24 hs with IFN1a, the expression of 868 genes was modified: 545 increased (including CXCL11, CCL8, INDO, IFI27, CFB, CXCL10 and IFIT1) and 323 diminished (including RBP7, SEPT5, RNF8, ADORA2B and FOS). Conclusions: Since many of them were previously recognized as involved in MS pathogenesis, the IFNb1a mechanism of action could imply a compensatory regulation of systems deregulated in MS.
Fil: Kauffman, Marcelo Andres. Biosidus S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Yankilevich, Patricio. Biosidus S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barrero, Paola Roxana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ricardo Bello. Biosidus S. A.; Argentina
Fil: Marangunich, L.. Biosidus S. A.; Argentina
Fil: Vidal, A.. Biosidus S. A.; Argentina
Fil: Criscuolo, M.. Biosidus S. A.; Argentina
Fil: Diez, Roberto Alejandro. Biosidus S. A.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sterin Prync, Aída Edith. Biosidus S. A.; Argentina
description Objectives: To characterize the IFN1a-regulated gene expression on leukocytes of Multiple Sclerosis (MS) patients using microarrays with whole human genome representation. Methods: Genes differentially expressed by interferon- were identified by a microarray in vitro study performed in leukocytes obtained from 5MS relapsing-remitting patients. Results: Following the culture of peripheral blood mononuclear cells from MS relapsing-remitting patients for 24 hs with IFN1a, the expression of 868 genes was modified: 545 increased (including CXCL11, CCL8, INDO, IFI27, CFB, CXCL10 and IFIT1) and 323 diminished (including RBP7, SEPT5, RNF8, ADORA2B and FOS). Conclusions: Since many of them were previously recognized as involved in MS pathogenesis, the IFNb1a mechanism of action could imply a compensatory regulation of systems deregulated in MS.
publishDate 2009
dc.date.none.fl_str_mv 2009-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/148228
Kauffman, Marcelo Andres; Yankilevich, Patricio; Barrero, Paola Roxana; Ricardo Bello; Marangunich, L.; et al.; Whole genome analysis of the action of interferon-β; Dustri-Verlag Dr. Karl Feistle; International Journal of Clinical Pharmacology and Therapeutics; 47; 5; 5-2009; 328-357
0946-1965
CONICET Digital
CONICET
url http://hdl.handle.net/11336/148228
identifier_str_mv Kauffman, Marcelo Andres; Yankilevich, Patricio; Barrero, Paola Roxana; Ricardo Bello; Marangunich, L.; et al.; Whole genome analysis of the action of interferon-β; Dustri-Verlag Dr. Karl Feistle; International Journal of Clinical Pharmacology and Therapeutics; 47; 5; 5-2009; 328-357
0946-1965
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.dustri.com/article_response_page.html?artId=5980&doi=10.5414/CPP47328&L=0
info:eu-repo/semantics/altIdentifier/doi/10.5414/CPP47328
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Dustri-Verlag Dr. Karl Feistle
publisher.none.fl_str_mv Dustri-Verlag Dr. Karl Feistle
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614186499309568
score 13.070432

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