Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport...

Autores
Naso, Luciana Gissella; Valcarcel, María; Roura Ferrer, Meritxell; Kortazar, Danel; Salado, Clarisa; Lezama, Luis; Rojo, Teófilo; Gonzalez Baro, Ana Cecilia; Williams, Patricia Ana María; Ferrer, Evelina Gloria
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A new chlorogenate oxidovanadium complex (Na[VO(chlorog)(H 2O)3].4H2O) was synthesized by using Schlenk methodology in the course of a reaction at inert atmosphere in which deprotonated chlorogenic acid ligand binds to oxidovanadium(IV) in a reaction experiment controlled via EPR technique and based in a species distribution diagram. The compound was characterized by FTIR, EPR, UV-visible and diffuse reflectance spectroscopies and thermogravimetric, differential thermal and elemental analyses. The ligand and the complex were tested for their antioxidant effects on DPPH (1,1-diphenyl-2-picrylhydrazyl radical), ABTS+ (radical cation of 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt), O2-, OH and ROO radicals and their cytotoxic activity on different cancer cell lines (SKBR3, T47D and MDAMB231) and primary human mammary epithelial cells. The complex behaved as good antioxidant agent with strongest inhibitory effects on O2-, OH and ROO radicals and exhibited selective cytotoxicity against SKBR3 cancer cell line. Albumin interaction experiments denoted high affinity toward the complex and its calculated binding constant was indicative of a strong binding to the protein. Based on this study, it is hypothesized that Na[VO(chlorog)(H 2O)3].4H2O would be a promising candidate for further evaluation as an antioxidant and anticancer agent.
Fil: Naso, Luciana Gissella. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; Argentina
Fil: Valcarcel, María. Innoprot Sl;
Fil: Roura-Ferrer, Meritxell. Innoprot Sl;
Fil: Kortazar, Danel. Innoprot Sl;
Fil: Salado, Clarisa. Innoprot Sl;
Fil: Lezama, Luis Raul. Universidad del País Vasco; España
Fil: Rojo, Teofilo. Universidad del País Vasco; España
Fil: Gonzalez Baro, Ana Cecilia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; Argentina
Fil: Williams, Patricia Ana María. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; Argentina
Fil: Ferrer, Evelina Gloria. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; Argentina
Materia
ALBUMIN INTERACTION
ANTICANCER ACTIVITY
ANTIOXIDANT ACTIVITY
CHLOROGENIC ACID
OXIDOVANADIUM(IV)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93259
Acceder
id CONICETDig_03d39e8695f5c3bfcd48d11ca7d11171
oai_identifier_str oai:ri.conicet.gov.ar:11336/93259
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albuminNaso, Luciana GissellaValcarcel, MaríaRoura Ferrer, MeritxellKortazar, DanelSalado, ClarisaLezama, LuisRojo, TeófiloGonzalez Baro, Ana CeciliaWilliams, Patricia Ana MaríaFerrer, Evelina GloriaALBUMIN INTERACTIONANTICANCER ACTIVITYANTIOXIDANT ACTIVITYCHLOROGENIC ACIDOXIDOVANADIUM(IV)https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A new chlorogenate oxidovanadium complex (Na[VO(chlorog)(H 2O)3].4H2O) was synthesized by using Schlenk methodology in the course of a reaction at inert atmosphere in which deprotonated chlorogenic acid ligand binds to oxidovanadium(IV) in a reaction experiment controlled via EPR technique and based in a species distribution diagram. The compound was characterized by FTIR, EPR, UV-visible and diffuse reflectance spectroscopies and thermogravimetric, differential thermal and elemental analyses. The ligand and the complex were tested for their antioxidant effects on DPPH (1,1-diphenyl-2-picrylhydrazyl radical), ABTS+ (radical cation of 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt), O2-, OH and ROO radicals and their cytotoxic activity on different cancer cell lines (SKBR3, T47D and MDAMB231) and primary human mammary epithelial cells. The complex behaved as good antioxidant agent with strongest inhibitory effects on O2-, OH and ROO radicals and exhibited selective cytotoxicity against SKBR3 cancer cell line. Albumin interaction experiments denoted high affinity toward the complex and its calculated binding constant was indicative of a strong binding to the protein. Based on this study, it is hypothesized that Na[VO(chlorog)(H 2O)3].4H2O would be a promising candidate for further evaluation as an antioxidant and anticancer agent.Fil: Naso, Luciana Gissella. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; ArgentinaFil: Valcarcel, María. Innoprot Sl;Fil: Roura-Ferrer, Meritxell. Innoprot Sl;Fil: Kortazar, Danel. Innoprot Sl;Fil: Salado, Clarisa. Innoprot Sl;Fil: Lezama, Luis Raul. Universidad del País Vasco; EspañaFil: Rojo, Teofilo. Universidad del País Vasco; EspañaFil: Gonzalez Baro, Ana Cecilia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; ArgentinaFil: Williams, Patricia Ana María. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; ArgentinaFil: Ferrer, Evelina Gloria. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; ArgentinaElsevier Science Inc2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93259Naso, Luciana Gissella; Valcarcel, María; Roura Ferrer, Meritxell; Kortazar, Danel; Salado, Clarisa; et al.; Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin; Elsevier Science Inc; Journal of Inorganic Biochemistry; 135; 3-2014; 86-990162-0134CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0162013414000646info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2014.02.013info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:57Zoai:ri.conicet.gov.ar:11336/93259instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:57.892CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin
title Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin
spellingShingle Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin
Naso, Luciana Gissella
ALBUMIN INTERACTION
ANTICANCER ACTIVITY
ANTIOXIDANT ACTIVITY
CHLOROGENIC ACID
OXIDOVANADIUM(IV)
title_short Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin
title_full Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin
title_fullStr Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin
title_full_unstemmed Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin
title_sort Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin
dc.creator.none.fl_str_mv Naso, Luciana Gissella
Valcarcel, María
Roura Ferrer, Meritxell
Kortazar, Danel
Salado, Clarisa
Lezama, Luis
Rojo, Teófilo
Gonzalez Baro, Ana Cecilia
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author Naso, Luciana Gissella
author_facet Naso, Luciana Gissella
Valcarcel, María
Roura Ferrer, Meritxell
Kortazar, Danel
Salado, Clarisa
Lezama, Luis
Rojo, Teófilo
Gonzalez Baro, Ana Cecilia
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author_role author
author2 Valcarcel, María
Roura Ferrer, Meritxell
Kortazar, Danel
Salado, Clarisa
Lezama, Luis
Rojo, Teófilo
Gonzalez Baro, Ana Cecilia
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALBUMIN INTERACTION
ANTICANCER ACTIVITY
ANTIOXIDANT ACTIVITY
CHLOROGENIC ACID
OXIDOVANADIUM(IV)
topic ALBUMIN INTERACTION
ANTICANCER ACTIVITY
ANTIOXIDANT ACTIVITY
CHLOROGENIC ACID
OXIDOVANADIUM(IV)
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A new chlorogenate oxidovanadium complex (Na[VO(chlorog)(H 2O)3].4H2O) was synthesized by using Schlenk methodology in the course of a reaction at inert atmosphere in which deprotonated chlorogenic acid ligand binds to oxidovanadium(IV) in a reaction experiment controlled via EPR technique and based in a species distribution diagram. The compound was characterized by FTIR, EPR, UV-visible and diffuse reflectance spectroscopies and thermogravimetric, differential thermal and elemental analyses. The ligand and the complex were tested for their antioxidant effects on DPPH (1,1-diphenyl-2-picrylhydrazyl radical), ABTS+ (radical cation of 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt), O2-, OH and ROO radicals and their cytotoxic activity on different cancer cell lines (SKBR3, T47D and MDAMB231) and primary human mammary epithelial cells. The complex behaved as good antioxidant agent with strongest inhibitory effects on O2-, OH and ROO radicals and exhibited selective cytotoxicity against SKBR3 cancer cell line. Albumin interaction experiments denoted high affinity toward the complex and its calculated binding constant was indicative of a strong binding to the protein. Based on this study, it is hypothesized that Na[VO(chlorog)(H 2O)3].4H2O would be a promising candidate for further evaluation as an antioxidant and anticancer agent.
Fil: Naso, Luciana Gissella. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; Argentina
Fil: Valcarcel, María. Innoprot Sl;
Fil: Roura-Ferrer, Meritxell. Innoprot Sl;
Fil: Kortazar, Danel. Innoprot Sl;
Fil: Salado, Clarisa. Innoprot Sl;
Fil: Lezama, Luis Raul. Universidad del País Vasco; España
Fil: Rojo, Teofilo. Universidad del País Vasco; España
Fil: Gonzalez Baro, Ana Cecilia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; Argentina
Fil: Williams, Patricia Ana María. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; Argentina
Fil: Ferrer, Evelina Gloria. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química; Argentina
description A new chlorogenate oxidovanadium complex (Na[VO(chlorog)(H 2O)3].4H2O) was synthesized by using Schlenk methodology in the course of a reaction at inert atmosphere in which deprotonated chlorogenic acid ligand binds to oxidovanadium(IV) in a reaction experiment controlled via EPR technique and based in a species distribution diagram. The compound was characterized by FTIR, EPR, UV-visible and diffuse reflectance spectroscopies and thermogravimetric, differential thermal and elemental analyses. The ligand and the complex were tested for their antioxidant effects on DPPH (1,1-diphenyl-2-picrylhydrazyl radical), ABTS+ (radical cation of 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt), O2-, OH and ROO radicals and their cytotoxic activity on different cancer cell lines (SKBR3, T47D and MDAMB231) and primary human mammary epithelial cells. The complex behaved as good antioxidant agent with strongest inhibitory effects on O2-, OH and ROO radicals and exhibited selective cytotoxicity against SKBR3 cancer cell line. Albumin interaction experiments denoted high affinity toward the complex and its calculated binding constant was indicative of a strong binding to the protein. Based on this study, it is hypothesized that Na[VO(chlorog)(H 2O)3].4H2O would be a promising candidate for further evaluation as an antioxidant and anticancer agent.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93259
Naso, Luciana Gissella; Valcarcel, María; Roura Ferrer, Meritxell; Kortazar, Danel; Salado, Clarisa; et al.; Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin; Elsevier Science Inc; Journal of Inorganic Biochemistry; 135; 3-2014; 86-99
0162-0134
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93259
identifier_str_mv Naso, Luciana Gissella; Valcarcel, María; Roura Ferrer, Meritxell; Kortazar, Danel; Salado, Clarisa; et al.; Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin; Elsevier Science Inc; Journal of Inorganic Biochemistry; 135; 3-2014; 86-99
0162-0134
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0162013414000646
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2014.02.013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270025102131200
score 13.13397

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