Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs

Autores
Dib, A.; Palma, Santiago Daniel; Suárez, G.; Farías, C.; Cabrera, P.; Castro, Silvina Gabriela; Allemandi, Daniel Alberto; Moreno, Laura Susana; Lanusse, Carlos Edmundo; Sanchez Bruni, Sergio Fabian
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
New therapeutic strategies based on the search of alternative formulations of albendazole (ABZ) and albendazole sulphoxide (ABZSO) are under current development to optimize posology and antiparasite efficacy in dogs. In an incomplete block design, nine dogs were randomly divided into three groups (n=6). Treatments were carried out in two phases as follows. Phase I: Group I (treatment A), animals received ABZ at 25mg/kg of conventional formulation. Group II (treatment B), dogs received 25mg/kg of a modified poloxamer-ABZ formulation. Group III (treatment C), animals were treated with ABZSO in equimolar amount to ABZ doses. After 21days of wash-out period the experiment was repeated (Phase II). Blood samples were collected over 24h and subsequently analysed by high performance liquid chromatography. ABZSO and ABZSO 2 were the analytes recovered in plasma. Significant higher (P<0.001) ABZSO area under the concentration-time curve (+500%) and C max (+487%) values were obtained for the treatment C in comparison with treatments A and B. However, no statistical differences on pharmacokinetic parameters were found between formulations A and B. In conclusion, the enhanced plasma concentration profile obtained for the ABZSO formulation used in treatment C may contribute to optimize the anthelmintic control in dogs.
Fil: Dib, A.. Universidad de la República; Uruguay
Fil: Palma, Santiago Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Suárez, G.. Universidad de la República; Uruguay
Fil: Farías, C.. Universidad de la República; Uruguay
Fil: Cabrera, P.. Universidad de la República; Uruguay
Fil: Castro, Silvina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moreno, Laura Susana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sanchez Bruni, Sergio Fabian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Albendazole
Dissolution Rate
Poloxamer
Solid Dispersions
Surfactant
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/71503
Acceder
id CONICETDig_03b946c299aa4bd906be47d00199346d
oai_identifier_str oai:ri.conicet.gov.ar:11336/71503
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogsDib, A.Palma, Santiago DanielSuárez, G.Farías, C.Cabrera, P.Castro, Silvina GabrielaAllemandi, Daniel AlbertoMoreno, Laura SusanaLanusse, Carlos EdmundoSanchez Bruni, Sergio FabianAlbendazoleDissolution RatePoloxamerSolid DispersionsSurfactanthttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4New therapeutic strategies based on the search of alternative formulations of albendazole (ABZ) and albendazole sulphoxide (ABZSO) are under current development to optimize posology and antiparasite efficacy in dogs. In an incomplete block design, nine dogs were randomly divided into three groups (n=6). Treatments were carried out in two phases as follows. Phase I: Group I (treatment A), animals received ABZ at 25mg/kg of conventional formulation. Group II (treatment B), dogs received 25mg/kg of a modified poloxamer-ABZ formulation. Group III (treatment C), animals were treated with ABZSO in equimolar amount to ABZ doses. After 21days of wash-out period the experiment was repeated (Phase II). Blood samples were collected over 24h and subsequently analysed by high performance liquid chromatography. ABZSO and ABZSO 2 were the analytes recovered in plasma. Significant higher (P<0.001) ABZSO area under the concentration-time curve (+500%) and C max (+487%) values were obtained for the treatment C in comparison with treatments A and B. However, no statistical differences on pharmacokinetic parameters were found between formulations A and B. In conclusion, the enhanced plasma concentration profile obtained for the ABZSO formulation used in treatment C may contribute to optimize the anthelmintic control in dogs.Fil: Dib, A.. Universidad de la República; UruguayFil: Palma, Santiago Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Suárez, G.. Universidad de la República; UruguayFil: Farías, C.. Universidad de la República; UruguayFil: Cabrera, P.. Universidad de la República; UruguayFil: Castro, Silvina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Moreno, Laura Susana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sanchez Bruni, Sergio Fabian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley Blackwell Publishing, Inc2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/71503Dib, A.; Palma, Santiago Daniel; Suárez, G.; Farías, C.; Cabrera, P.; et al.; Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 34; 2; 4-2011; 136-1410140-7783CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2885.2010.01203.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2885.2010.01203.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:27:23Zoai:ri.conicet.gov.ar:11336/71503instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:27:23.908CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs
title Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs
spellingShingle Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs
Dib, A.
Albendazole
Dissolution Rate
Poloxamer
Solid Dispersions
Surfactant
title_short Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs
title_full Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs
title_fullStr Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs
title_full_unstemmed Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs
title_sort Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs
dc.creator.none.fl_str_mv Dib, A.
Palma, Santiago Daniel
Suárez, G.
Farías, C.
Cabrera, P.
Castro, Silvina Gabriela
Allemandi, Daniel Alberto
Moreno, Laura Susana
Lanusse, Carlos Edmundo
Sanchez Bruni, Sergio Fabian
author Dib, A.
author_facet Dib, A.
Palma, Santiago Daniel
Suárez, G.
Farías, C.
Cabrera, P.
Castro, Silvina Gabriela
Allemandi, Daniel Alberto
Moreno, Laura Susana
Lanusse, Carlos Edmundo
Sanchez Bruni, Sergio Fabian
author_role author
author2 Palma, Santiago Daniel
Suárez, G.
Farías, C.
Cabrera, P.
Castro, Silvina Gabriela
Allemandi, Daniel Alberto
Moreno, Laura Susana
Lanusse, Carlos Edmundo
Sanchez Bruni, Sergio Fabian
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Albendazole
Dissolution Rate
Poloxamer
Solid Dispersions
Surfactant
topic Albendazole
Dissolution Rate
Poloxamer
Solid Dispersions
Surfactant
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv New therapeutic strategies based on the search of alternative formulations of albendazole (ABZ) and albendazole sulphoxide (ABZSO) are under current development to optimize posology and antiparasite efficacy in dogs. In an incomplete block design, nine dogs were randomly divided into three groups (n=6). Treatments were carried out in two phases as follows. Phase I: Group I (treatment A), animals received ABZ at 25mg/kg of conventional formulation. Group II (treatment B), dogs received 25mg/kg of a modified poloxamer-ABZ formulation. Group III (treatment C), animals were treated with ABZSO in equimolar amount to ABZ doses. After 21days of wash-out period the experiment was repeated (Phase II). Blood samples were collected over 24h and subsequently analysed by high performance liquid chromatography. ABZSO and ABZSO 2 were the analytes recovered in plasma. Significant higher (P<0.001) ABZSO area under the concentration-time curve (+500%) and C max (+487%) values were obtained for the treatment C in comparison with treatments A and B. However, no statistical differences on pharmacokinetic parameters were found between formulations A and B. In conclusion, the enhanced plasma concentration profile obtained for the ABZSO formulation used in treatment C may contribute to optimize the anthelmintic control in dogs.
Fil: Dib, A.. Universidad de la República; Uruguay
Fil: Palma, Santiago Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Suárez, G.. Universidad de la República; Uruguay
Fil: Farías, C.. Universidad de la República; Uruguay
Fil: Cabrera, P.. Universidad de la República; Uruguay
Fil: Castro, Silvina Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Moreno, Laura Susana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lanusse, Carlos Edmundo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sanchez Bruni, Sergio Fabian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description New therapeutic strategies based on the search of alternative formulations of albendazole (ABZ) and albendazole sulphoxide (ABZSO) are under current development to optimize posology and antiparasite efficacy in dogs. In an incomplete block design, nine dogs were randomly divided into three groups (n=6). Treatments were carried out in two phases as follows. Phase I: Group I (treatment A), animals received ABZ at 25mg/kg of conventional formulation. Group II (treatment B), dogs received 25mg/kg of a modified poloxamer-ABZ formulation. Group III (treatment C), animals were treated with ABZSO in equimolar amount to ABZ doses. After 21days of wash-out period the experiment was repeated (Phase II). Blood samples were collected over 24h and subsequently analysed by high performance liquid chromatography. ABZSO and ABZSO 2 were the analytes recovered in plasma. Significant higher (P<0.001) ABZSO area under the concentration-time curve (+500%) and C max (+487%) values were obtained for the treatment C in comparison with treatments A and B. However, no statistical differences on pharmacokinetic parameters were found between formulations A and B. In conclusion, the enhanced plasma concentration profile obtained for the ABZSO formulation used in treatment C may contribute to optimize the anthelmintic control in dogs.
publishDate 2011
dc.date.none.fl_str_mv 2011-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/71503
Dib, A.; Palma, Santiago Daniel; Suárez, G.; Farías, C.; Cabrera, P.; et al.; Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 34; 2; 4-2011; 136-141
0140-7783
CONICET Digital
CONICET
url http://hdl.handle.net/11336/71503
identifier_str_mv Dib, A.; Palma, Santiago Daniel; Suárez, G.; Farías, C.; Cabrera, P.; et al.; Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 34; 2; 4-2011; 136-141
0140-7783
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2885.2010.01203.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2885.2010.01203.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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