A web server for identification and analysis of coevolution in overlapping proteins
- Autores
- Teppa, Roxana Elin; Carbone, Alessandra
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Overlapping genes exist in all domains of life and are especially abundant in viral genomes. The existence of overlapping reading frames increases the rising of deleterious mutations for one of the proteins, since a single nucleotide substitution may affect both proteins. Molecular coevolution may be seen as a mechanism to tolerate or compensate unfavorable mutations, decreasing the evolutionary constraints in the overlapping region. For instance, a favorable mutation in one reading frame may be unfavorable in the other reading frame and additional mutations may be needed to compensate the first mutation. Although molecular coevolution was widely used in viral genomes, the "overlap problem" was disregarded. Here, we present a server that facilitates the analysis of coevolution in overlapping proteins and of the impact of mutations in another ORF.
Fil: Teppa, Roxana Elin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Sorbonne University; Francia
Fil: Carbone, Alessandra. Universite de la Mediterranee. Institut Universitaire de France; Francia. Sorbonne University; Francia
Journées Ouvertes De Biologie Informatique & Mathématiques
Nantes
Francia
French Society of BioInformatics
GdR Bioinformatique Moléculaire
Institut Francais de Bioinformatique - Materia
-
coevolution
compensatory mutations
virus
overlapping proteins - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/156982
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
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A web server for identification and analysis of coevolution in overlapping proteinsTeppa, Roxana ElinCarbone, Alessandracoevolutioncompensatory mutationsvirusoverlapping proteinshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Overlapping genes exist in all domains of life and are especially abundant in viral genomes. The existence of overlapping reading frames increases the rising of deleterious mutations for one of the proteins, since a single nucleotide substitution may affect both proteins. Molecular coevolution may be seen as a mechanism to tolerate or compensate unfavorable mutations, decreasing the evolutionary constraints in the overlapping region. For instance, a favorable mutation in one reading frame may be unfavorable in the other reading frame and additional mutations may be needed to compensate the first mutation. Although molecular coevolution was widely used in viral genomes, the "overlap problem" was disregarded. Here, we present a server that facilitates the analysis of coevolution in overlapping proteins and of the impact of mutations in another ORF.Fil: Teppa, Roxana Elin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Sorbonne University; FranciaFil: Carbone, Alessandra. Universite de la Mediterranee. Institut Universitaire de France; Francia. Sorbonne University; FranciaJournées Ouvertes De Biologie Informatique & MathématiquesNantesFranciaFrench Society of BioInformaticsGdR Bioinformatique MoléculaireInstitut Francais de BioinformatiqueFrench Society of BioInformatics2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectJornadaJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/156982A web server for identification and analysis of coevolution in overlapping proteins; Journées Ouvertes De Biologie Informatique & Mathématiques; Nantes; Francia; 2019; 179-182CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://uncloud.univ-nantes.fr/index.php/s/wsXfE8zqEaqsiNk#pdfviewerinfo:eu-repo/semantics/altIdentifier/url/https://jobim2019.sciencesconf.org/?forward-action=index&forward-controller=index&lang=enNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:32Zoai:ri.conicet.gov.ar:11336/156982instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:32.954CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A web server for identification and analysis of coevolution in overlapping proteins |
title |
A web server for identification and analysis of coevolution in overlapping proteins |
spellingShingle |
A web server for identification and analysis of coevolution in overlapping proteins Teppa, Roxana Elin coevolution compensatory mutations virus overlapping proteins |
title_short |
A web server for identification and analysis of coevolution in overlapping proteins |
title_full |
A web server for identification and analysis of coevolution in overlapping proteins |
title_fullStr |
A web server for identification and analysis of coevolution in overlapping proteins |
title_full_unstemmed |
A web server for identification and analysis of coevolution in overlapping proteins |
title_sort |
A web server for identification and analysis of coevolution in overlapping proteins |
dc.creator.none.fl_str_mv |
Teppa, Roxana Elin Carbone, Alessandra |
author |
Teppa, Roxana Elin |
author_facet |
Teppa, Roxana Elin Carbone, Alessandra |
author_role |
author |
author2 |
Carbone, Alessandra |
author2_role |
author |
dc.subject.none.fl_str_mv |
coevolution compensatory mutations virus overlapping proteins |
topic |
coevolution compensatory mutations virus overlapping proteins |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Overlapping genes exist in all domains of life and are especially abundant in viral genomes. The existence of overlapping reading frames increases the rising of deleterious mutations for one of the proteins, since a single nucleotide substitution may affect both proteins. Molecular coevolution may be seen as a mechanism to tolerate or compensate unfavorable mutations, decreasing the evolutionary constraints in the overlapping region. For instance, a favorable mutation in one reading frame may be unfavorable in the other reading frame and additional mutations may be needed to compensate the first mutation. Although molecular coevolution was widely used in viral genomes, the "overlap problem" was disregarded. Here, we present a server that facilitates the analysis of coevolution in overlapping proteins and of the impact of mutations in another ORF. Fil: Teppa, Roxana Elin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Sorbonne University; Francia Fil: Carbone, Alessandra. Universite de la Mediterranee. Institut Universitaire de France; Francia. Sorbonne University; Francia Journées Ouvertes De Biologie Informatique & Mathématiques Nantes Francia French Society of BioInformatics GdR Bioinformatique Moléculaire Institut Francais de Bioinformatique |
description |
Overlapping genes exist in all domains of life and are especially abundant in viral genomes. The existence of overlapping reading frames increases the rising of deleterious mutations for one of the proteins, since a single nucleotide substitution may affect both proteins. Molecular coevolution may be seen as a mechanism to tolerate or compensate unfavorable mutations, decreasing the evolutionary constraints in the overlapping region. For instance, a favorable mutation in one reading frame may be unfavorable in the other reading frame and additional mutations may be needed to compensate the first mutation. Although molecular coevolution was widely used in viral genomes, the "overlap problem" was disregarded. Here, we present a server that facilitates the analysis of coevolution in overlapping proteins and of the impact of mutations in another ORF. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Jornada Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/156982 A web server for identification and analysis of coevolution in overlapping proteins; Journées Ouvertes De Biologie Informatique & Mathématiques; Nantes; Francia; 2019; 179-182 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/156982 |
identifier_str_mv |
A web server for identification and analysis of coevolution in overlapping proteins; Journées Ouvertes De Biologie Informatique & Mathématiques; Nantes; Francia; 2019; 179-182 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://uncloud.univ-nantes.fr/index.php/s/wsXfE8zqEaqsiNk#pdfviewer info:eu-repo/semantics/altIdentifier/url/https://jobim2019.sciencesconf.org/?forward-action=index&forward-controller=index&lang=en |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/msword application/pdf |
dc.coverage.none.fl_str_mv |
Nacional |
dc.publisher.none.fl_str_mv |
French Society of BioInformatics |
publisher.none.fl_str_mv |
French Society of BioInformatics |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269165994377216 |
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13.13397 |