A web server for identification and analysis of coevolution in overlapping proteins

Autores
Teppa, Roxana Elin; Carbone, Alessandra
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Overlapping genes exist in all domains of life and are especially abundant in viral genomes. The existence of overlapping reading frames increases the rising of deleterious mutations for one of the proteins, since a single nucleotide substitution may affect both proteins. Molecular coevolution may be seen as a mechanism to tolerate or compensate unfavorable mutations, decreasing the evolutionary constraints in the overlapping region. For instance, a favorable mutation in one reading frame may be unfavorable in the other reading frame and additional mutations may be needed to compensate the first mutation. Although molecular coevolution was widely used in viral genomes, the "overlap problem" was disregarded. Here, we present a server that facilitates the analysis of coevolution in overlapping proteins and of the impact of mutations in another ORF.
Fil: Teppa, Roxana Elin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Sorbonne University; Francia
Fil: Carbone, Alessandra. Universite de la Mediterranee. Institut Universitaire de France; Francia. Sorbonne University; Francia
Journées Ouvertes De Biologie Informatique & Mathématiques
Nantes
Francia
French Society of BioInformatics
GdR Bioinformatique Moléculaire
Institut Francais de Bioinformatique
Materia
coevolution
compensatory mutations
virus
overlapping proteins
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/156982
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A web server for identification and analysis of coevolution in overlapping proteinsTeppa, Roxana ElinCarbone, Alessandracoevolutioncompensatory mutationsvirusoverlapping proteinshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Overlapping genes exist in all domains of life and are especially abundant in viral genomes. The existence of overlapping reading frames increases the rising of deleterious mutations for one of the proteins, since a single nucleotide substitution may affect both proteins. Molecular coevolution may be seen as a mechanism to tolerate or compensate unfavorable mutations, decreasing the evolutionary constraints in the overlapping region. For instance, a favorable mutation in one reading frame may be unfavorable in the other reading frame and additional mutations may be needed to compensate the first mutation. Although molecular coevolution was widely used in viral genomes, the "overlap problem" was disregarded. Here, we present a server that facilitates the analysis of coevolution in overlapping proteins and of the impact of mutations in another ORF.Fil: Teppa, Roxana Elin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Sorbonne University; FranciaFil: Carbone, Alessandra. Universite de la Mediterranee. Institut Universitaire de France; Francia. Sorbonne University; FranciaJournées Ouvertes De Biologie Informatique & MathématiquesNantesFranciaFrench Society of BioInformaticsGdR Bioinformatique MoléculaireInstitut Francais de BioinformatiqueFrench Society of BioInformatics2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectJornadaJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/156982A web server for identification and analysis of coevolution in overlapping proteins; Journées Ouvertes De Biologie Informatique & Mathématiques; Nantes; Francia; 2019; 179-182CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://uncloud.univ-nantes.fr/index.php/s/wsXfE8zqEaqsiNk#pdfviewerinfo:eu-repo/semantics/altIdentifier/url/https://jobim2019.sciencesconf.org/?forward-action=index&forward-controller=index&lang=enNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:27Zoai:ri.conicet.gov.ar:11336/156982instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:27.987CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A web server for identification and analysis of coevolution in overlapping proteins
title A web server for identification and analysis of coevolution in overlapping proteins
spellingShingle A web server for identification and analysis of coevolution in overlapping proteins
Teppa, Roxana Elin
coevolution
compensatory mutations
virus
overlapping proteins
title_short A web server for identification and analysis of coevolution in overlapping proteins
title_full A web server for identification and analysis of coevolution in overlapping proteins
title_fullStr A web server for identification and analysis of coevolution in overlapping proteins
title_full_unstemmed A web server for identification and analysis of coevolution in overlapping proteins
title_sort A web server for identification and analysis of coevolution in overlapping proteins
dc.creator.none.fl_str_mv Teppa, Roxana Elin
Carbone, Alessandra
author Teppa, Roxana Elin
author_facet Teppa, Roxana Elin
Carbone, Alessandra
author_role author
author2 Carbone, Alessandra
author2_role author
dc.subject.none.fl_str_mv coevolution
compensatory mutations
virus
overlapping proteins
topic coevolution
compensatory mutations
virus
overlapping proteins
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Overlapping genes exist in all domains of life and are especially abundant in viral genomes. The existence of overlapping reading frames increases the rising of deleterious mutations for one of the proteins, since a single nucleotide substitution may affect both proteins. Molecular coevolution may be seen as a mechanism to tolerate or compensate unfavorable mutations, decreasing the evolutionary constraints in the overlapping region. For instance, a favorable mutation in one reading frame may be unfavorable in the other reading frame and additional mutations may be needed to compensate the first mutation. Although molecular coevolution was widely used in viral genomes, the "overlap problem" was disregarded. Here, we present a server that facilitates the analysis of coevolution in overlapping proteins and of the impact of mutations in another ORF.
Fil: Teppa, Roxana Elin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Sorbonne University; Francia
Fil: Carbone, Alessandra. Universite de la Mediterranee. Institut Universitaire de France; Francia. Sorbonne University; Francia
Journées Ouvertes De Biologie Informatique & Mathématiques
Nantes
Francia
French Society of BioInformatics
GdR Bioinformatique Moléculaire
Institut Francais de Bioinformatique
description Overlapping genes exist in all domains of life and are especially abundant in viral genomes. The existence of overlapping reading frames increases the rising of deleterious mutations for one of the proteins, since a single nucleotide substitution may affect both proteins. Molecular coevolution may be seen as a mechanism to tolerate or compensate unfavorable mutations, decreasing the evolutionary constraints in the overlapping region. For instance, a favorable mutation in one reading frame may be unfavorable in the other reading frame and additional mutations may be needed to compensate the first mutation. Although molecular coevolution was widely used in viral genomes, the "overlap problem" was disregarded. Here, we present a server that facilitates the analysis of coevolution in overlapping proteins and of the impact of mutations in another ORF.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Jornada
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/156982
A web server for identification and analysis of coevolution in overlapping proteins; Journées Ouvertes De Biologie Informatique & Mathématiques; Nantes; Francia; 2019; 179-182
CONICET Digital
CONICET
url http://hdl.handle.net/11336/156982
identifier_str_mv A web server for identification and analysis of coevolution in overlapping proteins; Journées Ouvertes De Biologie Informatique & Mathématiques; Nantes; Francia; 2019; 179-182
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://uncloud.univ-nantes.fr/index.php/s/wsXfE8zqEaqsiNk#pdfviewer
info:eu-repo/semantics/altIdentifier/url/https://jobim2019.sciencesconf.org/?forward-action=index&forward-controller=index&lang=en
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv French Society of BioInformatics
publisher.none.fl_str_mv French Society of BioInformatics
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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