Tinnitus treatment with oxytocin: A pilot study
- Autores
- Azevedo, Andreia Aparecida; Figueiredo, Ricardo Rodrigues; Elgoyhen, Ana Belen; Langguth, Berthold; Penido, Norma De Oliveira; Schlee, Winfried
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Introduction: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. Objective: To evaluate the potential of oxytocin as a tinnitus treatment. Study design: Two studies were performed. Study 1 was a long-term open pilot study, while study 2 investigated short-term effects with a double-blinded placebo-controlled cross-over study. Setting: Ambulatory ENT care. Subjects and method: In study 1, 15 patients were investigated over a 10-week period in an open pilot study. In study 2, 16 patients were included in a placebo-controlled crossover trial to investigate short-term effects following a single dose. Results: For the long-term study (study 1), analysis of variance revealed a significant decrease in tinnitus sensation, both for the Tinnitus Handicap Inventory and Clinical Global Impression (CGI). Also, the short-term effects in study 2 revealed a significant reduction of tinnitus because of the oxytocin nasal spray as measured with the Visual Analog Scale and the CGI Scale. Conclusion: These preliminary studies demonstrated that oxytocin may represent a helpful tool for treating tinnitus and further larger controlled studies are warranted.
Fil: Azevedo, Andreia Aparecida. Universidad Federal de Sao Paulo; Brasil
Fil: Figueiredo, Ricardo Rodrigues. Universidad Federal de Sao Paulo; Brasil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Langguth, Berthold. Universitat Regensburg; Alemania
Fil: Penido, Norma De Oliveira. Universidad Federal de Sao Paulo; Brasil
Fil: Schlee, Winfried. Universitat Regensburg; Alemania - Materia
-
HEARING DISORDERS
NASAL SPRAYS
OXYTOCIN
PHARMACOTHERAPY
TINNITUS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/65534
Ver los metadatos del registro completo
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Tinnitus treatment with oxytocin: A pilot studyAzevedo, Andreia AparecidaFigueiredo, Ricardo RodriguesElgoyhen, Ana BelenLangguth, BertholdPenido, Norma De OliveiraSchlee, WinfriedHEARING DISORDERSNASAL SPRAYSOXYTOCINPHARMACOTHERAPYTINNITUShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. Objective: To evaluate the potential of oxytocin as a tinnitus treatment. Study design: Two studies were performed. Study 1 was a long-term open pilot study, while study 2 investigated short-term effects with a double-blinded placebo-controlled cross-over study. Setting: Ambulatory ENT care. Subjects and method: In study 1, 15 patients were investigated over a 10-week period in an open pilot study. In study 2, 16 patients were included in a placebo-controlled crossover trial to investigate short-term effects following a single dose. Results: For the long-term study (study 1), analysis of variance revealed a significant decrease in tinnitus sensation, both for the Tinnitus Handicap Inventory and Clinical Global Impression (CGI). Also, the short-term effects in study 2 revealed a significant reduction of tinnitus because of the oxytocin nasal spray as measured with the Visual Analog Scale and the CGI Scale. Conclusion: These preliminary studies demonstrated that oxytocin may represent a helpful tool for treating tinnitus and further larger controlled studies are warranted.Fil: Azevedo, Andreia Aparecida. Universidad Federal de Sao Paulo; BrasilFil: Figueiredo, Ricardo Rodrigues. Universidad Federal de Sao Paulo; BrasilFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Langguth, Berthold. Universitat Regensburg; AlemaniaFil: Penido, Norma De Oliveira. Universidad Federal de Sao Paulo; BrasilFil: Schlee, Winfried. Universitat Regensburg; AlemaniaFrontiers Research Foundation2017-09-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/65534Azevedo, Andreia Aparecida; Figueiredo, Ricardo Rodrigues; Elgoyhen, Ana Belen; Langguth, Berthold; Penido, Norma De Oliveira; et al.; Tinnitus treatment with oxytocin: A pilot study; Frontiers Research Foundation; Frontiers in Neurology; 8; SEP; 21-9-2017; 1-7; 4941664-2295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2017.00494info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2017.00494/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:49Zoai:ri.conicet.gov.ar:11336/65534instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:49.804CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Tinnitus treatment with oxytocin: A pilot study |
title |
Tinnitus treatment with oxytocin: A pilot study |
spellingShingle |
Tinnitus treatment with oxytocin: A pilot study Azevedo, Andreia Aparecida HEARING DISORDERS NASAL SPRAYS OXYTOCIN PHARMACOTHERAPY TINNITUS |
title_short |
Tinnitus treatment with oxytocin: A pilot study |
title_full |
Tinnitus treatment with oxytocin: A pilot study |
title_fullStr |
Tinnitus treatment with oxytocin: A pilot study |
title_full_unstemmed |
Tinnitus treatment with oxytocin: A pilot study |
title_sort |
Tinnitus treatment with oxytocin: A pilot study |
dc.creator.none.fl_str_mv |
Azevedo, Andreia Aparecida Figueiredo, Ricardo Rodrigues Elgoyhen, Ana Belen Langguth, Berthold Penido, Norma De Oliveira Schlee, Winfried |
author |
Azevedo, Andreia Aparecida |
author_facet |
Azevedo, Andreia Aparecida Figueiredo, Ricardo Rodrigues Elgoyhen, Ana Belen Langguth, Berthold Penido, Norma De Oliveira Schlee, Winfried |
author_role |
author |
author2 |
Figueiredo, Ricardo Rodrigues Elgoyhen, Ana Belen Langguth, Berthold Penido, Norma De Oliveira Schlee, Winfried |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
HEARING DISORDERS NASAL SPRAYS OXYTOCIN PHARMACOTHERAPY TINNITUS |
topic |
HEARING DISORDERS NASAL SPRAYS OXYTOCIN PHARMACOTHERAPY TINNITUS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Introduction: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. Objective: To evaluate the potential of oxytocin as a tinnitus treatment. Study design: Two studies were performed. Study 1 was a long-term open pilot study, while study 2 investigated short-term effects with a double-blinded placebo-controlled cross-over study. Setting: Ambulatory ENT care. Subjects and method: In study 1, 15 patients were investigated over a 10-week period in an open pilot study. In study 2, 16 patients were included in a placebo-controlled crossover trial to investigate short-term effects following a single dose. Results: For the long-term study (study 1), analysis of variance revealed a significant decrease in tinnitus sensation, both for the Tinnitus Handicap Inventory and Clinical Global Impression (CGI). Also, the short-term effects in study 2 revealed a significant reduction of tinnitus because of the oxytocin nasal spray as measured with the Visual Analog Scale and the CGI Scale. Conclusion: These preliminary studies demonstrated that oxytocin may represent a helpful tool for treating tinnitus and further larger controlled studies are warranted. Fil: Azevedo, Andreia Aparecida. Universidad Federal de Sao Paulo; Brasil Fil: Figueiredo, Ricardo Rodrigues. Universidad Federal de Sao Paulo; Brasil Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Langguth, Berthold. Universitat Regensburg; Alemania Fil: Penido, Norma De Oliveira. Universidad Federal de Sao Paulo; Brasil Fil: Schlee, Winfried. Universitat Regensburg; Alemania |
description |
Introduction: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. Objective: To evaluate the potential of oxytocin as a tinnitus treatment. Study design: Two studies were performed. Study 1 was a long-term open pilot study, while study 2 investigated short-term effects with a double-blinded placebo-controlled cross-over study. Setting: Ambulatory ENT care. Subjects and method: In study 1, 15 patients were investigated over a 10-week period in an open pilot study. In study 2, 16 patients were included in a placebo-controlled crossover trial to investigate short-term effects following a single dose. Results: For the long-term study (study 1), analysis of variance revealed a significant decrease in tinnitus sensation, both for the Tinnitus Handicap Inventory and Clinical Global Impression (CGI). Also, the short-term effects in study 2 revealed a significant reduction of tinnitus because of the oxytocin nasal spray as measured with the Visual Analog Scale and the CGI Scale. Conclusion: These preliminary studies demonstrated that oxytocin may represent a helpful tool for treating tinnitus and further larger controlled studies are warranted. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-21 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/65534 Azevedo, Andreia Aparecida; Figueiredo, Ricardo Rodrigues; Elgoyhen, Ana Belen; Langguth, Berthold; Penido, Norma De Oliveira; et al.; Tinnitus treatment with oxytocin: A pilot study; Frontiers Research Foundation; Frontiers in Neurology; 8; SEP; 21-9-2017; 1-7; 494 1664-2295 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/65534 |
identifier_str_mv |
Azevedo, Andreia Aparecida; Figueiredo, Ricardo Rodrigues; Elgoyhen, Ana Belen; Langguth, Berthold; Penido, Norma De Oliveira; et al.; Tinnitus treatment with oxytocin: A pilot study; Frontiers Research Foundation; Frontiers in Neurology; 8; SEP; 21-9-2017; 1-7; 494 1664-2295 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2017.00494 info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2017.00494/full |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Research Foundation |
publisher.none.fl_str_mv |
Frontiers Research Foundation |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269603246374912 |
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13.13397 |