Tinnitus treatment with oxytocin: A pilot study

Autores
Azevedo, Andreia Aparecida; Figueiredo, Ricardo Rodrigues; Elgoyhen, Ana Belen; Langguth, Berthold; Penido, Norma De Oliveira; Schlee, Winfried
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. Objective: To evaluate the potential of oxytocin as a tinnitus treatment. Study design: Two studies were performed. Study 1 was a long-term open pilot study, while study 2 investigated short-term effects with a double-blinded placebo-controlled cross-over study. Setting: Ambulatory ENT care. Subjects and method: In study 1, 15 patients were investigated over a 10-week period in an open pilot study. In study 2, 16 patients were included in a placebo-controlled crossover trial to investigate short-term effects following a single dose. Results: For the long-term study (study 1), analysis of variance revealed a significant decrease in tinnitus sensation, both for the Tinnitus Handicap Inventory and Clinical Global Impression (CGI). Also, the short-term effects in study 2 revealed a significant reduction of tinnitus because of the oxytocin nasal spray as measured with the Visual Analog Scale and the CGI Scale. Conclusion: These preliminary studies demonstrated that oxytocin may represent a helpful tool for treating tinnitus and further larger controlled studies are warranted.
Fil: Azevedo, Andreia Aparecida. Universidad Federal de Sao Paulo; Brasil
Fil: Figueiredo, Ricardo Rodrigues. Universidad Federal de Sao Paulo; Brasil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Langguth, Berthold. Universitat Regensburg; Alemania
Fil: Penido, Norma De Oliveira. Universidad Federal de Sao Paulo; Brasil
Fil: Schlee, Winfried. Universitat Regensburg; Alemania
Materia
HEARING DISORDERS
NASAL SPRAYS
OXYTOCIN
PHARMACOTHERAPY
TINNITUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/65534
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/65534
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tinnitus treatment with oxytocin: A pilot studyAzevedo, Andreia AparecidaFigueiredo, Ricardo RodriguesElgoyhen, Ana BelenLangguth, BertholdPenido, Norma De OliveiraSchlee, WinfriedHEARING DISORDERSNASAL SPRAYSOXYTOCINPHARMACOTHERAPYTINNITUShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. Objective: To evaluate the potential of oxytocin as a tinnitus treatment. Study design: Two studies were performed. Study 1 was a long-term open pilot study, while study 2 investigated short-term effects with a double-blinded placebo-controlled cross-over study. Setting: Ambulatory ENT care. Subjects and method: In study 1, 15 patients were investigated over a 10-week period in an open pilot study. In study 2, 16 patients were included in a placebo-controlled crossover trial to investigate short-term effects following a single dose. Results: For the long-term study (study 1), analysis of variance revealed a significant decrease in tinnitus sensation, both for the Tinnitus Handicap Inventory and Clinical Global Impression (CGI). Also, the short-term effects in study 2 revealed a significant reduction of tinnitus because of the oxytocin nasal spray as measured with the Visual Analog Scale and the CGI Scale. Conclusion: These preliminary studies demonstrated that oxytocin may represent a helpful tool for treating tinnitus and further larger controlled studies are warranted.Fil: Azevedo, Andreia Aparecida. Universidad Federal de Sao Paulo; BrasilFil: Figueiredo, Ricardo Rodrigues. Universidad Federal de Sao Paulo; BrasilFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Langguth, Berthold. Universitat Regensburg; AlemaniaFil: Penido, Norma De Oliveira. Universidad Federal de Sao Paulo; BrasilFil: Schlee, Winfried. Universitat Regensburg; AlemaniaFrontiers Research Foundation2017-09-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/65534Azevedo, Andreia Aparecida; Figueiredo, Ricardo Rodrigues; Elgoyhen, Ana Belen; Langguth, Berthold; Penido, Norma De Oliveira; et al.; Tinnitus treatment with oxytocin: A pilot study; Frontiers Research Foundation; Frontiers in Neurology; 8; SEP; 21-9-2017; 1-7; 4941664-2295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2017.00494info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2017.00494/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T10:14:07Zoai:ri.conicet.gov.ar:11336/65534instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 10:14:08.041CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tinnitus treatment with oxytocin: A pilot study
title Tinnitus treatment with oxytocin: A pilot study
spellingShingle Tinnitus treatment with oxytocin: A pilot study
Azevedo, Andreia Aparecida
HEARING DISORDERS
NASAL SPRAYS
OXYTOCIN
PHARMACOTHERAPY
TINNITUS
title_short Tinnitus treatment with oxytocin: A pilot study
title_full Tinnitus treatment with oxytocin: A pilot study
title_fullStr Tinnitus treatment with oxytocin: A pilot study
title_full_unstemmed Tinnitus treatment with oxytocin: A pilot study
title_sort Tinnitus treatment with oxytocin: A pilot study
dc.creator.none.fl_str_mv Azevedo, Andreia Aparecida
Figueiredo, Ricardo Rodrigues
Elgoyhen, Ana Belen
Langguth, Berthold
Penido, Norma De Oliveira
Schlee, Winfried
author Azevedo, Andreia Aparecida
author_facet Azevedo, Andreia Aparecida
Figueiredo, Ricardo Rodrigues
Elgoyhen, Ana Belen
Langguth, Berthold
Penido, Norma De Oliveira
Schlee, Winfried
author_role author
author2 Figueiredo, Ricardo Rodrigues
Elgoyhen, Ana Belen
Langguth, Berthold
Penido, Norma De Oliveira
Schlee, Winfried
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv HEARING DISORDERS
NASAL SPRAYS
OXYTOCIN
PHARMACOTHERAPY
TINNITUS
topic HEARING DISORDERS
NASAL SPRAYS
OXYTOCIN
PHARMACOTHERAPY
TINNITUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. Objective: To evaluate the potential of oxytocin as a tinnitus treatment. Study design: Two studies were performed. Study 1 was a long-term open pilot study, while study 2 investigated short-term effects with a double-blinded placebo-controlled cross-over study. Setting: Ambulatory ENT care. Subjects and method: In study 1, 15 patients were investigated over a 10-week period in an open pilot study. In study 2, 16 patients were included in a placebo-controlled crossover trial to investigate short-term effects following a single dose. Results: For the long-term study (study 1), analysis of variance revealed a significant decrease in tinnitus sensation, both for the Tinnitus Handicap Inventory and Clinical Global Impression (CGI). Also, the short-term effects in study 2 revealed a significant reduction of tinnitus because of the oxytocin nasal spray as measured with the Visual Analog Scale and the CGI Scale. Conclusion: These preliminary studies demonstrated that oxytocin may represent a helpful tool for treating tinnitus and further larger controlled studies are warranted.
Fil: Azevedo, Andreia Aparecida. Universidad Federal de Sao Paulo; Brasil
Fil: Figueiredo, Ricardo Rodrigues. Universidad Federal de Sao Paulo; Brasil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Langguth, Berthold. Universitat Regensburg; Alemania
Fil: Penido, Norma De Oliveira. Universidad Federal de Sao Paulo; Brasil
Fil: Schlee, Winfried. Universitat Regensburg; Alemania
description Introduction: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. Objective: To evaluate the potential of oxytocin as a tinnitus treatment. Study design: Two studies were performed. Study 1 was a long-term open pilot study, while study 2 investigated short-term effects with a double-blinded placebo-controlled cross-over study. Setting: Ambulatory ENT care. Subjects and method: In study 1, 15 patients were investigated over a 10-week period in an open pilot study. In study 2, 16 patients were included in a placebo-controlled crossover trial to investigate short-term effects following a single dose. Results: For the long-term study (study 1), analysis of variance revealed a significant decrease in tinnitus sensation, both for the Tinnitus Handicap Inventory and Clinical Global Impression (CGI). Also, the short-term effects in study 2 revealed a significant reduction of tinnitus because of the oxytocin nasal spray as measured with the Visual Analog Scale and the CGI Scale. Conclusion: These preliminary studies demonstrated that oxytocin may represent a helpful tool for treating tinnitus and further larger controlled studies are warranted.
publishDate 2017
dc.date.none.fl_str_mv 2017-09-21
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/65534
Azevedo, Andreia Aparecida; Figueiredo, Ricardo Rodrigues; Elgoyhen, Ana Belen; Langguth, Berthold; Penido, Norma De Oliveira; et al.; Tinnitus treatment with oxytocin: A pilot study; Frontiers Research Foundation; Frontiers in Neurology; 8; SEP; 21-9-2017; 1-7; 494
1664-2295
CONICET Digital
CONICET
url http://hdl.handle.net/11336/65534
identifier_str_mv Azevedo, Andreia Aparecida; Figueiredo, Ricardo Rodrigues; Elgoyhen, Ana Belen; Langguth, Berthold; Penido, Norma De Oliveira; et al.; Tinnitus treatment with oxytocin: A pilot study; Frontiers Research Foundation; Frontiers in Neurology; 8; SEP; 21-9-2017; 1-7; 494
1664-2295
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2017.00494
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2017.00494/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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