Immunopathogenesis of reactive arthritis: role of the cytokines

Autores
Eliçabe, Ricardo Javier; Di Genaro, Maria Silvia
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Reactive arthritis (ReA), also known as postinfectious arthritis, belongs to the group of related arthropathies known as spondyloarthritis (SpA). ReA can arise 1-4 weeks after a gastrointestinal or genitourinary infection, but once arthritis develops the microorganism is not found in the joint. The classical microbes associated with ReA development include Gram-negative aerobic or microaerophilic bacteria containing LPS in their outer membrane. The immunopathogenic mechanisms involved in ReA development are still unknown. A hypothesis suggested that the bacteria probably persist outside the joint, at sites such as gut mucosa or lymph nodes and bacterial antigens might then be transported to the joints. On the other hand, an altered immune response and the unbalanced production of cytokines have been reported in subjects with ReA. Currently, there is increased evidence to suggest that both mechanisms would operate in the immunopathogenesis of ReA. In this review we highlight recent advances on the role of cytokines in the ReA. Particularly, we discuss the roles of some pro- and anti-inflammatory cytokines involved in the immunopathogenesis of ReA.
Fil: Eliçabe, Ricardo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Di Genaro, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Materia
Reactive arthritis
Cytokines
Immunophatogenesis
Infection
Interleukin-17
Interleukin-12
Interleukin-23
Interleukin-6
Tumor necrosis factor-α
Interleukin-10
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14503
Acceder
id CONICETDig_02bb22bac63d964ee16addefd6fa79dd
oai_identifier_str oai:ri.conicet.gov.ar:11336/14503
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Immunopathogenesis of reactive arthritis: role of the cytokinesEliçabe, Ricardo JavierDi Genaro, Maria SilviaReactive arthritisCytokinesImmunophatogenesisInfectionInterleukin-17Interleukin-12Interleukin-23Interleukin-6Tumor necrosis factor-αInterleukin-10https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Reactive arthritis (ReA), also known as postinfectious arthritis, belongs to the group of related arthropathies known as spondyloarthritis (SpA). ReA can arise 1-4 weeks after a gastrointestinal or genitourinary infection, but once arthritis develops the microorganism is not found in the joint. The classical microbes associated with ReA development include Gram-negative aerobic or microaerophilic bacteria containing LPS in their outer membrane. The immunopathogenic mechanisms involved in ReA development are still unknown. A hypothesis suggested that the bacteria probably persist outside the joint, at sites such as gut mucosa or lymph nodes and bacterial antigens might then be transported to the joints. On the other hand, an altered immune response and the unbalanced production of cytokines have been reported in subjects with ReA. Currently, there is increased evidence to suggest that both mechanisms would operate in the immunopathogenesis of ReA. In this review we highlight recent advances on the role of cytokines in the ReA. Particularly, we discuss the roles of some pro- and anti-inflammatory cytokines involved in the immunopathogenesis of ReA.Fil: Eliçabe, Ricardo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Di Genaro, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaBaishideng Publishing Group2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14503Eliçabe, Ricardo Javier; Di Genaro, Maria Silvia; Immunopathogenesis of reactive arthritis: role of the cytokines; Baishideng Publishing Group; World Journal of Immunology; 4; 2; 7-2014; 78-872219-2824enginfo:eu-repo/semantics/altIdentifier/url/http://www.wjgnet.com/2219-2824/full/v4/i2/78.htminfo:eu-repo/semantics/altIdentifier/doi/10.5411/wji.v4.i2.78info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:20:04Zoai:ri.conicet.gov.ar:11336/14503instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:20:04.831CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immunopathogenesis of reactive arthritis: role of the cytokines
title Immunopathogenesis of reactive arthritis: role of the cytokines
spellingShingle Immunopathogenesis of reactive arthritis: role of the cytokines
Eliçabe, Ricardo Javier
Reactive arthritis
Cytokines
Immunophatogenesis
Infection
Interleukin-17
Interleukin-12
Interleukin-23
Interleukin-6
Tumor necrosis factor-α
Interleukin-10
title_short Immunopathogenesis of reactive arthritis: role of the cytokines
title_full Immunopathogenesis of reactive arthritis: role of the cytokines
title_fullStr Immunopathogenesis of reactive arthritis: role of the cytokines
title_full_unstemmed Immunopathogenesis of reactive arthritis: role of the cytokines
title_sort Immunopathogenesis of reactive arthritis: role of the cytokines
dc.creator.none.fl_str_mv Eliçabe, Ricardo Javier
Di Genaro, Maria Silvia
author Eliçabe, Ricardo Javier
author_facet Eliçabe, Ricardo Javier
Di Genaro, Maria Silvia
author_role author
author2 Di Genaro, Maria Silvia
author2_role author
dc.subject.none.fl_str_mv Reactive arthritis
Cytokines
Immunophatogenesis
Infection
Interleukin-17
Interleukin-12
Interleukin-23
Interleukin-6
Tumor necrosis factor-α
Interleukin-10
topic Reactive arthritis
Cytokines
Immunophatogenesis
Infection
Interleukin-17
Interleukin-12
Interleukin-23
Interleukin-6
Tumor necrosis factor-α
Interleukin-10
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Reactive arthritis (ReA), also known as postinfectious arthritis, belongs to the group of related arthropathies known as spondyloarthritis (SpA). ReA can arise 1-4 weeks after a gastrointestinal or genitourinary infection, but once arthritis develops the microorganism is not found in the joint. The classical microbes associated with ReA development include Gram-negative aerobic or microaerophilic bacteria containing LPS in their outer membrane. The immunopathogenic mechanisms involved in ReA development are still unknown. A hypothesis suggested that the bacteria probably persist outside the joint, at sites such as gut mucosa or lymph nodes and bacterial antigens might then be transported to the joints. On the other hand, an altered immune response and the unbalanced production of cytokines have been reported in subjects with ReA. Currently, there is increased evidence to suggest that both mechanisms would operate in the immunopathogenesis of ReA. In this review we highlight recent advances on the role of cytokines in the ReA. Particularly, we discuss the roles of some pro- and anti-inflammatory cytokines involved in the immunopathogenesis of ReA.
Fil: Eliçabe, Ricardo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Di Genaro, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
description Reactive arthritis (ReA), also known as postinfectious arthritis, belongs to the group of related arthropathies known as spondyloarthritis (SpA). ReA can arise 1-4 weeks after a gastrointestinal or genitourinary infection, but once arthritis develops the microorganism is not found in the joint. The classical microbes associated with ReA development include Gram-negative aerobic or microaerophilic bacteria containing LPS in their outer membrane. The immunopathogenic mechanisms involved in ReA development are still unknown. A hypothesis suggested that the bacteria probably persist outside the joint, at sites such as gut mucosa or lymph nodes and bacterial antigens might then be transported to the joints. On the other hand, an altered immune response and the unbalanced production of cytokines have been reported in subjects with ReA. Currently, there is increased evidence to suggest that both mechanisms would operate in the immunopathogenesis of ReA. In this review we highlight recent advances on the role of cytokines in the ReA. Particularly, we discuss the roles of some pro- and anti-inflammatory cytokines involved in the immunopathogenesis of ReA.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14503
Eliçabe, Ricardo Javier; Di Genaro, Maria Silvia; Immunopathogenesis of reactive arthritis: role of the cytokines; Baishideng Publishing Group; World Journal of Immunology; 4; 2; 7-2014; 78-87
2219-2824
url http://hdl.handle.net/11336/14503
identifier_str_mv Eliçabe, Ricardo Javier; Di Genaro, Maria Silvia; Immunopathogenesis of reactive arthritis: role of the cytokines; Baishideng Publishing Group; World Journal of Immunology; 4; 2; 7-2014; 78-87
2219-2824
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.wjgnet.com/2219-2824/full/v4/i2/78.htm
info:eu-repo/semantics/altIdentifier/doi/10.5411/wji.v4.i2.78
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981099326668800
score 12.48226

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