Non-linear susceptibility to interferences in declarative memory formation

Autores
Moyano, Malen Daiana; Carbonari, Giuliana; Bonilla, Matías; Pedreira, Maria Eugenia; Brusco, Luis Ignacio; Kaczer, Laura; Forcato, Cecilia
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
After encoding, memories go through a labile state followed by a stabilizationprocess known as consolidation. Once consolidated they can enter a new labile stateafter the presentation of a reminder of the original memory, followed by a period of restabilization (reconsolidation). During these periods of lability the memory traces canbe modified. Currently, there are studies that show a rapid stabilization after 30 min,while others show that stabilization occurs after longer periods (e.g. 6 h). Here weinvestigate the effect of an interference treatment on declarative memoryconsolidation, comparing distinct time intervals after acquisition. On day 1, participantslearned a list of non- syllable pairs (List 1). Immediately after, 30 min, 3 h or 8 h later,they received an interference list (List 2) that acted as an amnesic agent. On day 2(48 h after training) participants had to recall List 1 first, followed by List 2. We foundthat the List 1 memory was susceptible to interference when the List 2 wasadministered immediately or 3 h after learning; however, shortly after acquisition (e.g.30 min) the List 1 memory becomes transiently protected against interference. Wepropose the possibility that this rapid memory protection could be induced by a fastand transient neocortical integration (where the memory is transiently protected)becoming partially independent from the hippocampus followed by a hippocampal reengagement where the memory becomes susceptible to interferences again. Ourresults open a discussion about the contribution of molecular and systemic aspects tomemory consolidation.
Fil: Moyano, Malen Daiana. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carbonari, Giuliana. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bonilla, Matías. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Brusco, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Kaczer, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CONSOLIDATION
DECLARATIVE MEMORY
TIME WINDOW OF LABILITY
INTERFERENCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/165540
Acceder
id CONICETDig_01b8f1e6c32e0570195eb5e8885e143f
oai_identifier_str oai:ri.conicet.gov.ar:11336/165540
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Non-linear susceptibility to interferences in declarative memory formationMoyano, Malen DaianaCarbonari, GiulianaBonilla, MatíasPedreira, Maria EugeniaBrusco, Luis IgnacioKaczer, LauraForcato, CeciliaCONSOLIDATIONDECLARATIVE MEMORYTIME WINDOW OF LABILITYINTERFERENCEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1After encoding, memories go through a labile state followed by a stabilizationprocess known as consolidation. Once consolidated they can enter a new labile stateafter the presentation of a reminder of the original memory, followed by a period of restabilization (reconsolidation). During these periods of lability the memory traces canbe modified. Currently, there are studies that show a rapid stabilization after 30 min,while others show that stabilization occurs after longer periods (e.g. 6 h). Here weinvestigate the effect of an interference treatment on declarative memoryconsolidation, comparing distinct time intervals after acquisition. On day 1, participantslearned a list of non- syllable pairs (List 1). Immediately after, 30 min, 3 h or 8 h later,they received an interference list (List 2) that acted as an amnesic agent. On day 2(48 h after training) participants had to recall List 1 first, followed by List 2. We foundthat the List 1 memory was susceptible to interference when the List 2 wasadministered immediately or 3 h after learning; however, shortly after acquisition (e.g.30 min) the List 1 memory becomes transiently protected against interference. Wepropose the possibility that this rapid memory protection could be induced by a fastand transient neocortical integration (where the memory is transiently protected)becoming partially independent from the hippocampus followed by a hippocampal reengagement where the memory becomes susceptible to interferences again. Ourresults open a discussion about the contribution of molecular and systemic aspects tomemory consolidation.Fil: Moyano, Malen Daiana. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carbonari, Giuliana. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bonilla, Matías. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Brusco, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Kaczer, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinabioRxiv2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/165540Moyano, Malen Daiana; Carbonari, Giuliana; Bonilla, Matías; Pedreira, Maria Eugenia; Brusco, Luis Ignacio; et al.; Non-linear susceptibility to interferences in declarative memory formation; bioRxiv; BioRxiv; 2021; 6-2021; 1-362692-8205CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1101/2021.06.29.450433info:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2021.06.29.450433v1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:23:58Zoai:ri.conicet.gov.ar:11336/165540instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:23:59.173CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Non-linear susceptibility to interferences in declarative memory formation
title Non-linear susceptibility to interferences in declarative memory formation
spellingShingle Non-linear susceptibility to interferences in declarative memory formation
Moyano, Malen Daiana
CONSOLIDATION
DECLARATIVE MEMORY
TIME WINDOW OF LABILITY
INTERFERENCE
title_short Non-linear susceptibility to interferences in declarative memory formation
title_full Non-linear susceptibility to interferences in declarative memory formation
title_fullStr Non-linear susceptibility to interferences in declarative memory formation
title_full_unstemmed Non-linear susceptibility to interferences in declarative memory formation
title_sort Non-linear susceptibility to interferences in declarative memory formation
dc.creator.none.fl_str_mv Moyano, Malen Daiana
Carbonari, Giuliana
Bonilla, Matías
Pedreira, Maria Eugenia
Brusco, Luis Ignacio
Kaczer, Laura
Forcato, Cecilia
author Moyano, Malen Daiana
author_facet Moyano, Malen Daiana
Carbonari, Giuliana
Bonilla, Matías
Pedreira, Maria Eugenia
Brusco, Luis Ignacio
Kaczer, Laura
Forcato, Cecilia
author_role author
author2 Carbonari, Giuliana
Bonilla, Matías
Pedreira, Maria Eugenia
Brusco, Luis Ignacio
Kaczer, Laura
Forcato, Cecilia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CONSOLIDATION
DECLARATIVE MEMORY
TIME WINDOW OF LABILITY
INTERFERENCE
topic CONSOLIDATION
DECLARATIVE MEMORY
TIME WINDOW OF LABILITY
INTERFERENCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv After encoding, memories go through a labile state followed by a stabilizationprocess known as consolidation. Once consolidated they can enter a new labile stateafter the presentation of a reminder of the original memory, followed by a period of restabilization (reconsolidation). During these periods of lability the memory traces canbe modified. Currently, there are studies that show a rapid stabilization after 30 min,while others show that stabilization occurs after longer periods (e.g. 6 h). Here weinvestigate the effect of an interference treatment on declarative memoryconsolidation, comparing distinct time intervals after acquisition. On day 1, participantslearned a list of non- syllable pairs (List 1). Immediately after, 30 min, 3 h or 8 h later,they received an interference list (List 2) that acted as an amnesic agent. On day 2(48 h after training) participants had to recall List 1 first, followed by List 2. We foundthat the List 1 memory was susceptible to interference when the List 2 wasadministered immediately or 3 h after learning; however, shortly after acquisition (e.g.30 min) the List 1 memory becomes transiently protected against interference. Wepropose the possibility that this rapid memory protection could be induced by a fastand transient neocortical integration (where the memory is transiently protected)becoming partially independent from the hippocampus followed by a hippocampal reengagement where the memory becomes susceptible to interferences again. Ourresults open a discussion about the contribution of molecular and systemic aspects tomemory consolidation.
Fil: Moyano, Malen Daiana. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carbonari, Giuliana. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bonilla, Matías. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pedreira, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Brusco, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Kaczer, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description After encoding, memories go through a labile state followed by a stabilizationprocess known as consolidation. Once consolidated they can enter a new labile stateafter the presentation of a reminder of the original memory, followed by a period of restabilization (reconsolidation). During these periods of lability the memory traces canbe modified. Currently, there are studies that show a rapid stabilization after 30 min,while others show that stabilization occurs after longer periods (e.g. 6 h). Here weinvestigate the effect of an interference treatment on declarative memoryconsolidation, comparing distinct time intervals after acquisition. On day 1, participantslearned a list of non- syllable pairs (List 1). Immediately after, 30 min, 3 h or 8 h later,they received an interference list (List 2) that acted as an amnesic agent. On day 2(48 h after training) participants had to recall List 1 first, followed by List 2. We foundthat the List 1 memory was susceptible to interference when the List 2 wasadministered immediately or 3 h after learning; however, shortly after acquisition (e.g.30 min) the List 1 memory becomes transiently protected against interference. Wepropose the possibility that this rapid memory protection could be induced by a fastand transient neocortical integration (where the memory is transiently protected)becoming partially independent from the hippocampus followed by a hippocampal reengagement where the memory becomes susceptible to interferences again. Ourresults open a discussion about the contribution of molecular and systemic aspects tomemory consolidation.
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/165540
Moyano, Malen Daiana; Carbonari, Giuliana; Bonilla, Matías; Pedreira, Maria Eugenia; Brusco, Luis Ignacio; et al.; Non-linear susceptibility to interferences in declarative memory formation; bioRxiv; BioRxiv; 2021; 6-2021; 1-36
2692-8205
CONICET Digital
CONICET
url http://hdl.handle.net/11336/165540
identifier_str_mv Moyano, Malen Daiana; Carbonari, Giuliana; Bonilla, Matías; Pedreira, Maria Eugenia; Brusco, Luis Ignacio; et al.; Non-linear susceptibility to interferences in declarative memory formation; bioRxiv; BioRxiv; 2021; 6-2021; 1-36
2692-8205
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1101/2021.06.29.450433
info:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2021.06.29.450433v1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv bioRxiv
publisher.none.fl_str_mv bioRxiv
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083386943209472
score 13.22299

Publicaciones similares