WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation

Autores
Guelman, Laura Ruth; Zorrilla Zubilete, María Aurelia; Rios, Hugo; Zieher, L.M.
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neonatal X-irradiation induces permanent abnormalities in cerebellar cortex cytoarchitecture and neurochemistry, as well as impairment in motor gait. The aim of the present work was to examine the potential protective properties of WR-2721 (Amifostine, Ethyol®), a free radical scavenger, against the above mentioned alterations by using a previously described neuroprotection assessment protocol.
Pre-irradiation treatment with amifostine was effective in partially preventing the cerebellar morphological damage and the motor gait impairment induced by ionizing radiation. No changes in cerebellar noradrenaline (NA) levels were detected in amifostine-treated  irradiated animals. These results suggest that it is possible to counteract radiation-induced damage in the cerebella and motor gait of neonatal rats through oxygen free radical scavenger administration prior to irradiation. The presence of the agent before the injury occurs, favors the efficacy of amifostine neuroprotective activity. Clinical implications of this model are related to the daily exposure of many people to different sources of radiation (accidental, diagnostical or therapeutical).
Fil: Guelman, Laura Ruth. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zorrilla Zubilete, María Aurelia. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rios, Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Zieher, L.M.. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Materia
NEUROPROTECTION
WR-2721
X-IRRADIATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/138275
Acceder
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network_name_str CONICET Digital (CONICET)
spelling WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiationGuelman, Laura RuthZorrilla Zubilete, María AureliaRios, HugoZieher, L.M.NEUROPROTECTIONWR-2721X-IRRADIATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Neonatal X-irradiation induces permanent abnormalities in cerebellar cortex cytoarchitecture and neurochemistry, as well as impairment in motor gait. The aim of the present work was to examine the potential protective properties of WR-2721 (Amifostine, Ethyol®), a free radical scavenger, against the above mentioned alterations by using a previously described neuroprotection assessment protocol.<br />Pre-irradiation treatment with amifostine was effective in partially preventing the cerebellar morphological damage and the motor gait impairment induced by ionizing radiation. No changes in cerebellar noradrenaline (NA) levels were detected in amifostine-treated  irradiated animals. These results suggest that it is possible to counteract radiation-induced damage in the cerebella and motor gait of neonatal rats through oxygen free radical scavenger administration prior to irradiation. The presence of the agent before the injury occurs, favors the efficacy of amifostine neuroprotective activity. Clinical implications of this model are related to the daily exposure of many people to different sources of radiation (accidental, diagnostical or therapeutical).Fil: Guelman, Laura Ruth. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zorrilla Zubilete, María Aurelia. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rios, Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Zieher, L.M.. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaPergamon-Elsevier Science Ltd2003-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138275Guelman, Laura Ruth; Zorrilla Zubilete, María Aurelia; Rios, Hugo; Zieher, L.M.; WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation; Pergamon-Elsevier Science Ltd; Neurochemistry International; 42; 5; 4-2003; 385-3910197-0186CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0197018602001365info:eu-repo/semantics/altIdentifier/doi/10.1016/S0197-0186(02)00136-5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:40:12Zoai:ri.conicet.gov.ar:11336/138275instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:40:12.957CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation
title WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation
spellingShingle WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation
Guelman, Laura Ruth
NEUROPROTECTION
WR-2721
X-IRRADIATION
title_short WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation
title_full WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation
title_fullStr WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation
title_full_unstemmed WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation
title_sort WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation
dc.creator.none.fl_str_mv Guelman, Laura Ruth
Zorrilla Zubilete, María Aurelia
Rios, Hugo
Zieher, L.M.
author Guelman, Laura Ruth
author_facet Guelman, Laura Ruth
Zorrilla Zubilete, María Aurelia
Rios, Hugo
Zieher, L.M.
author_role author
author2 Zorrilla Zubilete, María Aurelia
Rios, Hugo
Zieher, L.M.
author2_role author
author
author
dc.subject.none.fl_str_mv NEUROPROTECTION
WR-2721
X-IRRADIATION
topic NEUROPROTECTION
WR-2721
X-IRRADIATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neonatal X-irradiation induces permanent abnormalities in cerebellar cortex cytoarchitecture and neurochemistry, as well as impairment in motor gait. The aim of the present work was to examine the potential protective properties of WR-2721 (Amifostine, Ethyol®), a free radical scavenger, against the above mentioned alterations by using a previously described neuroprotection assessment protocol.<br />Pre-irradiation treatment with amifostine was effective in partially preventing the cerebellar morphological damage and the motor gait impairment induced by ionizing radiation. No changes in cerebellar noradrenaline (NA) levels were detected in amifostine-treated  irradiated animals. These results suggest that it is possible to counteract radiation-induced damage in the cerebella and motor gait of neonatal rats through oxygen free radical scavenger administration prior to irradiation. The presence of the agent before the injury occurs, favors the efficacy of amifostine neuroprotective activity. Clinical implications of this model are related to the daily exposure of many people to different sources of radiation (accidental, diagnostical or therapeutical).
Fil: Guelman, Laura Ruth. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zorrilla Zubilete, María Aurelia. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rios, Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Zieher, L.M.. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
description Neonatal X-irradiation induces permanent abnormalities in cerebellar cortex cytoarchitecture and neurochemistry, as well as impairment in motor gait. The aim of the present work was to examine the potential protective properties of WR-2721 (Amifostine, Ethyol®), a free radical scavenger, against the above mentioned alterations by using a previously described neuroprotection assessment protocol.<br />Pre-irradiation treatment with amifostine was effective in partially preventing the cerebellar morphological damage and the motor gait impairment induced by ionizing radiation. No changes in cerebellar noradrenaline (NA) levels were detected in amifostine-treated  irradiated animals. These results suggest that it is possible to counteract radiation-induced damage in the cerebella and motor gait of neonatal rats through oxygen free radical scavenger administration prior to irradiation. The presence of the agent before the injury occurs, favors the efficacy of amifostine neuroprotective activity. Clinical implications of this model are related to the daily exposure of many people to different sources of radiation (accidental, diagnostical or therapeutical).
publishDate 2003
dc.date.none.fl_str_mv 2003-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/138275
Guelman, Laura Ruth; Zorrilla Zubilete, María Aurelia; Rios, Hugo; Zieher, L.M.; WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation; Pergamon-Elsevier Science Ltd; Neurochemistry International; 42; 5; 4-2003; 385-391
0197-0186
CONICET Digital
CONICET
url http://hdl.handle.net/11336/138275
identifier_str_mv Guelman, Laura Ruth; Zorrilla Zubilete, María Aurelia; Rios, Hugo; Zieher, L.M.; WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation; Pergamon-Elsevier Science Ltd; Neurochemistry International; 42; 5; 4-2003; 385-391
0197-0186
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0197018602001365
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0197-0186(02)00136-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782072391204864
score 12.982451

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