WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation
- Autores
- Guelman, Laura Ruth; Zorrilla Zubilete, María Aurelia; Rios, Hugo; Zieher, L.M.
- Año de publicación
- 2003
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Neonatal X-irradiation induces permanent abnormalities in cerebellar cortex cytoarchitecture and neurochemistry, as well as impairment in motor gait. The aim of the present work was to examine the potential protective properties of WR-2721 (Amifostine, Ethyol®), a free radical scavenger, against the above mentioned alterations by using a previously described neuroprotection assessment protocol.
Pre-irradiation treatment with amifostine was effective in partially preventing the cerebellar morphological damage and the motor gait impairment induced by ionizing radiation. No changes in cerebellar noradrenaline (NA) levels were detected in amifostine-treated irradiated animals. These results suggest that it is possible to counteract radiation-induced damage in the cerebella and motor gait of neonatal rats through oxygen free radical scavenger administration prior to irradiation. The presence of the agent before the injury occurs, favors the efficacy of amifostine neuroprotective activity. Clinical implications of this model are related to the daily exposure of many people to different sources of radiation (accidental, diagnostical or therapeutical).
Fil: Guelman, Laura Ruth. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zorrilla Zubilete, María Aurelia. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rios, Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Zieher, L.M.. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina - Materia
-
NEUROPROTECTION
WR-2721
X-IRRADIATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/138275
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
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WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiationGuelman, Laura RuthZorrilla Zubilete, María AureliaRios, HugoZieher, L.M.NEUROPROTECTIONWR-2721X-IRRADIATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Neonatal X-irradiation induces permanent abnormalities in cerebellar cortex cytoarchitecture and neurochemistry, as well as impairment in motor gait. The aim of the present work was to examine the potential protective properties of WR-2721 (Amifostine, Ethyol®), a free radical scavenger, against the above mentioned alterations by using a previously described neuroprotection assessment protocol.<br />Pre-irradiation treatment with amifostine was effective in partially preventing the cerebellar morphological damage and the motor gait impairment induced by ionizing radiation. No changes in cerebellar noradrenaline (NA) levels were detected in amifostine-treated irradiated animals. These results suggest that it is possible to counteract radiation-induced damage in the cerebella and motor gait of neonatal rats through oxygen free radical scavenger administration prior to irradiation. The presence of the agent before the injury occurs, favors the efficacy of amifostine neuroprotective activity. Clinical implications of this model are related to the daily exposure of many people to different sources of radiation (accidental, diagnostical or therapeutical).Fil: Guelman, Laura Ruth. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zorrilla Zubilete, María Aurelia. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rios, Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Zieher, L.M.. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaPergamon-Elsevier Science Ltd2003-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138275Guelman, Laura Ruth; Zorrilla Zubilete, María Aurelia; Rios, Hugo; Zieher, L.M.; WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation; Pergamon-Elsevier Science Ltd; Neurochemistry International; 42; 5; 4-2003; 385-3910197-0186CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0197018602001365info:eu-repo/semantics/altIdentifier/doi/10.1016/S0197-0186(02)00136-5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:10:14Zoai:ri.conicet.gov.ar:11336/138275instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:10:14.8CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation |
title |
WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation |
spellingShingle |
WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation Guelman, Laura Ruth NEUROPROTECTION WR-2721 X-IRRADIATION |
title_short |
WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation |
title_full |
WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation |
title_fullStr |
WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation |
title_full_unstemmed |
WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation |
title_sort |
WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation |
dc.creator.none.fl_str_mv |
Guelman, Laura Ruth Zorrilla Zubilete, María Aurelia Rios, Hugo Zieher, L.M. |
author |
Guelman, Laura Ruth |
author_facet |
Guelman, Laura Ruth Zorrilla Zubilete, María Aurelia Rios, Hugo Zieher, L.M. |
author_role |
author |
author2 |
Zorrilla Zubilete, María Aurelia Rios, Hugo Zieher, L.M. |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
NEUROPROTECTION WR-2721 X-IRRADIATION |
topic |
NEUROPROTECTION WR-2721 X-IRRADIATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Neonatal X-irradiation induces permanent abnormalities in cerebellar cortex cytoarchitecture and neurochemistry, as well as impairment in motor gait. The aim of the present work was to examine the potential protective properties of WR-2721 (Amifostine, Ethyol®), a free radical scavenger, against the above mentioned alterations by using a previously described neuroprotection assessment protocol.<br />Pre-irradiation treatment with amifostine was effective in partially preventing the cerebellar morphological damage and the motor gait impairment induced by ionizing radiation. No changes in cerebellar noradrenaline (NA) levels were detected in amifostine-treated irradiated animals. These results suggest that it is possible to counteract radiation-induced damage in the cerebella and motor gait of neonatal rats through oxygen free radical scavenger administration prior to irradiation. The presence of the agent before the injury occurs, favors the efficacy of amifostine neuroprotective activity. Clinical implications of this model are related to the daily exposure of many people to different sources of radiation (accidental, diagnostical or therapeutical). Fil: Guelman, Laura Ruth. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Zorrilla Zubilete, María Aurelia. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Rios, Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Zieher, L.M.. Universidad de Buenos Aires. Facultad de Medicina. Cátedra de Farmacología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina |
description |
Neonatal X-irradiation induces permanent abnormalities in cerebellar cortex cytoarchitecture and neurochemistry, as well as impairment in motor gait. The aim of the present work was to examine the potential protective properties of WR-2721 (Amifostine, Ethyol®), a free radical scavenger, against the above mentioned alterations by using a previously described neuroprotection assessment protocol.<br />Pre-irradiation treatment with amifostine was effective in partially preventing the cerebellar morphological damage and the motor gait impairment induced by ionizing radiation. No changes in cerebellar noradrenaline (NA) levels were detected in amifostine-treated irradiated animals. These results suggest that it is possible to counteract radiation-induced damage in the cerebella and motor gait of neonatal rats through oxygen free radical scavenger administration prior to irradiation. The presence of the agent before the injury occurs, favors the efficacy of amifostine neuroprotective activity. Clinical implications of this model are related to the daily exposure of many people to different sources of radiation (accidental, diagnostical or therapeutical). |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/138275 Guelman, Laura Ruth; Zorrilla Zubilete, María Aurelia; Rios, Hugo; Zieher, L.M.; WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation; Pergamon-Elsevier Science Ltd; Neurochemistry International; 42; 5; 4-2003; 385-391 0197-0186 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/138275 |
identifier_str_mv |
Guelman, Laura Ruth; Zorrilla Zubilete, María Aurelia; Rios, Hugo; Zieher, L.M.; WR-2721 (amifostine, ethyol®) prevents motor and morphological changes induced by neonatal X-irradiation; Pergamon-Elsevier Science Ltd; Neurochemistry International; 42; 5; 4-2003; 385-391 0197-0186 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0197018602001365 info:eu-repo/semantics/altIdentifier/doi/10.1016/S0197-0186(02)00136-5 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613989757091840 |
score |
13.070432 |