Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population
- Autores
- Gimenez, Lucas G.; Momany, Allison M.; Poletta, Fernando A.; Krupitzki, Hugo B.; Gili, Juan A.; Busch, Tamara D.; Saleme, Cesar; Cosentino, Viviana R.; Pawluk, Mariela S.; Campaña, Hebe Edith; Gadow, Enrique C.; Murray, Jeffrey C.; Lopez-Camelo, Jorge S.
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión enviada
- Descripción
- Background. Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. PTB is often classified according to clinical presentation: Idiopathic (PTB-I), preterm premature rupture of membranes (PTB-PPROM), and medically induced (PTBM). The aim of this study was to evaluate the associations between specific candidate genes and clinical subtypes of PTB. Methods. 24 SNPs were genotyped in 18 candidate genes in 709 infant triads. Of them, 243 were PTB-I, 256 PTB-PPROM, and 210 PTB-M. These data were analyzed with a Family-Based Association. Results. PTB was nominally associated with rs2272365 in PON1, rs883319 in KCNN3, rs4458044 in CRHR1, and rs610277 in F3. Regarding clinical subtypes analysis, 3 SNPs were associated with PTB-I (rs2272365 in PON1, rs10178458 in COL4A3, and rs4458044 in CRHR1), rs610277 in F3 was associated with PTBPPROM, and rs883319 in KCNN3 and rs610277 in F3 were associated with PTB-M. Conclusions. Our study identified polymorphisms potentially associated with specific clinical subtypes of PTB in this Latin American population. These results could suggest a specific role of such genes in the mechanisms involved in each clinical subtype. Further studies are required to confirm our results and to determine the role of these genes in the pathophysiology of clinical subtypes.
- Materia
-
Pediatría
preterm birth
Background. Preterm birth (PTB)
candidate genes
clinical subtypes of PTB - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
- OAI Identificador
- oai:digital.cic.gba.gob.ar:11746/6847
Ver los metadatos del registro completo
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oai:digital.cic.gba.gob.ar:11746/6847 |
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spelling |
Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American populationGimenez, Lucas G.Momany, Allison M.Poletta, Fernando A.Krupitzki, Hugo B.Gili, Juan A.Busch, Tamara D.Saleme, CesarCosentino, Viviana R.Pawluk, Mariela S.Campaña, Hebe EdithGadow, Enrique C.Murray, Jeffrey C.Lopez-Camelo, Jorge S.Pediatríapreterm birthBackground. Preterm birth (PTB)candidate genesclinical subtypes of PTB<strong>Background. </strong>Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. PTB is often classified according to clinical presentation: Idiopathic (PTB-I), preterm premature rupture of membranes (PTB-PPROM), and medically induced (PTBM). The aim of this study was to evaluate the associations between specific candidate genes and clinical subtypes of PTB. <strong>Methods.</strong> 24 SNPs were genotyped in 18 candidate genes in 709 infant triads. Of them, 243 were PTB-I, 256 PTB-PPROM, and 210 PTB-M. These data were analyzed with a Family-Based Association. <strong>Results.</strong> PTB was nominally associated with rs2272365 in PON1, rs883319 in KCNN3, rs4458044 in CRHR1, and rs610277 in F3. Regarding clinical subtypes analysis, 3 SNPs were associated with PTB-I (rs2272365 in PON1, rs10178458 in COL4A3, and rs4458044 in CRHR1), rs610277 in F3 was associated with PTBPPROM, and rs883319 in KCNN3 and rs610277 in F3 were associated with PTB-M. <strong>Conclusions.</strong> Our study identified polymorphisms potentially associated with specific clinical subtypes of PTB in this Latin American population. These results could suggest a specific role of such genes in the mechanisms involved in each clinical subtype. Further studies are required to confirm our results and to determine the role of these genes in the pathophysiology of clinical subtypes.2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://digital.cic.gba.gob.ar/handle/11746/6847enginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/reponame:CIC Digital (CICBA)instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Airesinstacron:CICBA2025-09-04T09:43:27Zoai:digital.cic.gba.gob.ar:11746/6847Institucionalhttp://digital.cic.gba.gob.arOrganismo científico-tecnológicoNo correspondehttp://digital.cic.gba.gob.ar/oai/snrdmarisa.degiusti@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:94412025-09-04 09:43:27.622CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Airesfalse |
dc.title.none.fl_str_mv |
Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population |
title |
Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population |
spellingShingle |
Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population Gimenez, Lucas G. Pediatría preterm birth Background. Preterm birth (PTB) candidate genes clinical subtypes of PTB |
title_short |
Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population |
title_full |
Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population |
title_fullStr |
Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population |
title_full_unstemmed |
Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population |
title_sort |
Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population |
dc.creator.none.fl_str_mv |
Gimenez, Lucas G. Momany, Allison M. Poletta, Fernando A. Krupitzki, Hugo B. Gili, Juan A. Busch, Tamara D. Saleme, Cesar Cosentino, Viviana R. Pawluk, Mariela S. Campaña, Hebe Edith Gadow, Enrique C. Murray, Jeffrey C. Lopez-Camelo, Jorge S. |
author |
Gimenez, Lucas G. |
author_facet |
Gimenez, Lucas G. Momany, Allison M. Poletta, Fernando A. Krupitzki, Hugo B. Gili, Juan A. Busch, Tamara D. Saleme, Cesar Cosentino, Viviana R. Pawluk, Mariela S. Campaña, Hebe Edith Gadow, Enrique C. Murray, Jeffrey C. Lopez-Camelo, Jorge S. |
author_role |
author |
author2 |
Momany, Allison M. Poletta, Fernando A. Krupitzki, Hugo B. Gili, Juan A. Busch, Tamara D. Saleme, Cesar Cosentino, Viviana R. Pawluk, Mariela S. Campaña, Hebe Edith Gadow, Enrique C. Murray, Jeffrey C. Lopez-Camelo, Jorge S. |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Pediatría preterm birth Background. Preterm birth (PTB) candidate genes clinical subtypes of PTB |
topic |
Pediatría preterm birth Background. Preterm birth (PTB) candidate genes clinical subtypes of PTB |
dc.description.none.fl_txt_mv |
<strong>Background. </strong>Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. PTB is often classified according to clinical presentation: Idiopathic (PTB-I), preterm premature rupture of membranes (PTB-PPROM), and medically induced (PTBM). The aim of this study was to evaluate the associations between specific candidate genes and clinical subtypes of PTB. <strong>Methods.</strong> 24 SNPs were genotyped in 18 candidate genes in 709 infant triads. Of them, 243 were PTB-I, 256 PTB-PPROM, and 210 PTB-M. These data were analyzed with a Family-Based Association. <strong>Results.</strong> PTB was nominally associated with rs2272365 in PON1, rs883319 in KCNN3, rs4458044 in CRHR1, and rs610277 in F3. Regarding clinical subtypes analysis, 3 SNPs were associated with PTB-I (rs2272365 in PON1, rs10178458 in COL4A3, and rs4458044 in CRHR1), rs610277 in F3 was associated with PTBPPROM, and rs883319 in KCNN3 and rs610277 in F3 were associated with PTB-M. <strong>Conclusions.</strong> Our study identified polymorphisms potentially associated with specific clinical subtypes of PTB in this Latin American population. These results could suggest a specific role of such genes in the mechanisms involved in each clinical subtype. Further studies are required to confirm our results and to determine the role of these genes in the pathophysiology of clinical subtypes. |
description |
<strong>Background. </strong>Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. PTB is often classified according to clinical presentation: Idiopathic (PTB-I), preterm premature rupture of membranes (PTB-PPROM), and medically induced (PTBM). The aim of this study was to evaluate the associations between specific candidate genes and clinical subtypes of PTB. <strong>Methods.</strong> 24 SNPs were genotyped in 18 candidate genes in 709 infant triads. Of them, 243 were PTB-I, 256 PTB-PPROM, and 210 PTB-M. These data were analyzed with a Family-Based Association. <strong>Results.</strong> PTB was nominally associated with rs2272365 in PON1, rs883319 in KCNN3, rs4458044 in CRHR1, and rs610277 in F3. Regarding clinical subtypes analysis, 3 SNPs were associated with PTB-I (rs2272365 in PON1, rs10178458 in COL4A3, and rs4458044 in CRHR1), rs610277 in F3 was associated with PTBPPROM, and rs883319 in KCNN3 and rs610277 in F3 were associated with PTB-M. <strong>Conclusions.</strong> Our study identified polymorphisms potentially associated with specific clinical subtypes of PTB in this Latin American population. These results could suggest a specific role of such genes in the mechanisms involved in each clinical subtype. Further studies are required to confirm our results and to determine the role of these genes in the pathophysiology of clinical subtypes. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/submittedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
submittedVersion |
dc.identifier.none.fl_str_mv |
https://digital.cic.gba.gob.ar/handle/11746/6847 |
url |
https://digital.cic.gba.gob.ar/handle/11746/6847 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ |
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application/pdf |
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Comisión de Investigaciones Científicas de la Provincia de Buenos Aires |
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CICBA |
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CICBA |
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CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Aires |
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marisa.degiusti@sedici.unlp.edu.ar |
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