Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population

Autores
Gimenez, Lucas G.; Momany, Allison M.; Poletta, Fernando A.; Krupitzki, Hugo B.; Gili, Juan A.; Busch, Tamara D.; Saleme, Cesar; Cosentino, Viviana R.; Pawluk, Mariela S.; Campaña, Hebe Edith; Gadow, Enrique C.; Murray, Jeffrey C.; Lopez-Camelo, Jorge S.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión enviada
Descripción
Background. Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. PTB is often classified according to clinical presentation: Idiopathic (PTB-I), preterm premature rupture of membranes (PTB-PPROM), and medically induced (PTBM). The aim of this study was to evaluate the associations between specific candidate genes and clinical subtypes of PTB. Methods. 24 SNPs were genotyped in 18 candidate genes in 709 infant triads. Of them, 243 were PTB-I, 256 PTB-PPROM, and 210 PTB-M. These data were analyzed with a Family-Based Association. Results. PTB was nominally associated with rs2272365 in PON1, rs883319 in KCNN3, rs4458044 in CRHR1, and rs610277 in F3. Regarding clinical subtypes analysis, 3 SNPs were associated with PTB-I (rs2272365 in PON1, rs10178458 in COL4A3, and rs4458044 in CRHR1), rs610277 in F3 was associated with PTBPPROM, and rs883319 in KCNN3 and rs610277 in F3 were associated with PTB-M. Conclusions. Our study identified polymorphisms potentially associated with specific clinical subtypes of PTB in this Latin American population. These results could suggest a specific role of such genes in the mechanisms involved in each clinical subtype. Further studies are required to confirm our results and to determine the role of these genes in the pathophysiology of clinical subtypes.
Materia
Pediatría
preterm birth
Background. Preterm birth (PTB)
candidate genes
clinical subtypes of PTB
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
CIC Digital (CICBA)
Institución
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
OAI Identificador
oai:digital.cic.gba.gob.ar:11746/6847

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network_acronym_str CICBA
repository_id_str 9441
network_name_str CIC Digital (CICBA)
spelling Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American populationGimenez, Lucas G.Momany, Allison M.Poletta, Fernando A.Krupitzki, Hugo B.Gili, Juan A.Busch, Tamara D.Saleme, CesarCosentino, Viviana R.Pawluk, Mariela S.Campaña, Hebe EdithGadow, Enrique C.Murray, Jeffrey C.Lopez-Camelo, Jorge S.Pediatríapreterm birthBackground. Preterm birth (PTB)candidate genesclinical subtypes of PTB<strong>Background. </strong>Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. PTB is often classified according to clinical presentation: Idiopathic (PTB-I), preterm premature rupture of membranes (PTB-PPROM), and medically induced (PTBM). The aim of this study was to evaluate the associations between specific candidate genes and clinical subtypes of PTB. <strong>Methods.</strong> 24 SNPs were genotyped in 18 candidate genes in 709 infant triads. Of them, 243 were PTB-I, 256 PTB-PPROM, and 210 PTB-M. These data were analyzed with a Family-Based Association. <strong>Results.</strong> PTB was nominally associated with rs2272365 in PON1, rs883319 in KCNN3, rs4458044 in CRHR1, and rs610277 in F3. Regarding clinical subtypes analysis, 3 SNPs were associated with PTB-I (rs2272365 in PON1, rs10178458 in COL4A3, and rs4458044 in CRHR1), rs610277 in F3 was associated with PTBPPROM, and rs883319 in KCNN3 and rs610277 in F3 were associated with PTB-M. <strong>Conclusions.</strong> Our study identified polymorphisms potentially associated with specific clinical subtypes of PTB in this Latin American population. These results could suggest a specific role of such genes in the mechanisms involved in each clinical subtype. Further studies are required to confirm our results and to determine the role of these genes in the pathophysiology of clinical subtypes.2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://digital.cic.gba.gob.ar/handle/11746/6847enginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/reponame:CIC Digital (CICBA)instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Airesinstacron:CICBA2025-09-04T09:43:27Zoai:digital.cic.gba.gob.ar:11746/6847Institucionalhttp://digital.cic.gba.gob.arOrganismo científico-tecnológicoNo correspondehttp://digital.cic.gba.gob.ar/oai/snrdmarisa.degiusti@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:94412025-09-04 09:43:27.622CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Airesfalse
dc.title.none.fl_str_mv Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population
title Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population
spellingShingle Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population
Gimenez, Lucas G.
Pediatría
preterm birth
Background. Preterm birth (PTB)
candidate genes
clinical subtypes of PTB
title_short Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population
title_full Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population
title_fullStr Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population
title_full_unstemmed Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population
title_sort Association of candidate gene polymorphisms with clinical subtypes of preterm birth in a Latin American population
dc.creator.none.fl_str_mv Gimenez, Lucas G.
Momany, Allison M.
Poletta, Fernando A.
Krupitzki, Hugo B.
Gili, Juan A.
Busch, Tamara D.
Saleme, Cesar
Cosentino, Viviana R.
Pawluk, Mariela S.
Campaña, Hebe Edith
Gadow, Enrique C.
Murray, Jeffrey C.
Lopez-Camelo, Jorge S.
author Gimenez, Lucas G.
author_facet Gimenez, Lucas G.
Momany, Allison M.
Poletta, Fernando A.
Krupitzki, Hugo B.
Gili, Juan A.
Busch, Tamara D.
Saleme, Cesar
Cosentino, Viviana R.
Pawluk, Mariela S.
Campaña, Hebe Edith
Gadow, Enrique C.
Murray, Jeffrey C.
Lopez-Camelo, Jorge S.
author_role author
author2 Momany, Allison M.
Poletta, Fernando A.
Krupitzki, Hugo B.
Gili, Juan A.
Busch, Tamara D.
Saleme, Cesar
Cosentino, Viviana R.
Pawluk, Mariela S.
Campaña, Hebe Edith
Gadow, Enrique C.
Murray, Jeffrey C.
Lopez-Camelo, Jorge S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pediatría
preterm birth
Background. Preterm birth (PTB)
candidate genes
clinical subtypes of PTB
topic Pediatría
preterm birth
Background. Preterm birth (PTB)
candidate genes
clinical subtypes of PTB
dc.description.none.fl_txt_mv <strong>Background. </strong>Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. PTB is often classified according to clinical presentation: Idiopathic (PTB-I), preterm premature rupture of membranes (PTB-PPROM), and medically induced (PTBM). The aim of this study was to evaluate the associations between specific candidate genes and clinical subtypes of PTB. <strong>Methods.</strong> 24 SNPs were genotyped in 18 candidate genes in 709 infant triads. Of them, 243 were PTB-I, 256 PTB-PPROM, and 210 PTB-M. These data were analyzed with a Family-Based Association. <strong>Results.</strong> PTB was nominally associated with rs2272365 in PON1, rs883319 in KCNN3, rs4458044 in CRHR1, and rs610277 in F3. Regarding clinical subtypes analysis, 3 SNPs were associated with PTB-I (rs2272365 in PON1, rs10178458 in COL4A3, and rs4458044 in CRHR1), rs610277 in F3 was associated with PTBPPROM, and rs883319 in KCNN3 and rs610277 in F3 were associated with PTB-M. <strong>Conclusions.</strong> Our study identified polymorphisms potentially associated with specific clinical subtypes of PTB in this Latin American population. These results could suggest a specific role of such genes in the mechanisms involved in each clinical subtype. Further studies are required to confirm our results and to determine the role of these genes in the pathophysiology of clinical subtypes.
description <strong>Background. </strong>Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity. PTB is often classified according to clinical presentation: Idiopathic (PTB-I), preterm premature rupture of membranes (PTB-PPROM), and medically induced (PTBM). The aim of this study was to evaluate the associations between specific candidate genes and clinical subtypes of PTB. <strong>Methods.</strong> 24 SNPs were genotyped in 18 candidate genes in 709 infant triads. Of them, 243 were PTB-I, 256 PTB-PPROM, and 210 PTB-M. These data were analyzed with a Family-Based Association. <strong>Results.</strong> PTB was nominally associated with rs2272365 in PON1, rs883319 in KCNN3, rs4458044 in CRHR1, and rs610277 in F3. Regarding clinical subtypes analysis, 3 SNPs were associated with PTB-I (rs2272365 in PON1, rs10178458 in COL4A3, and rs4458044 in CRHR1), rs610277 in F3 was associated with PTBPPROM, and rs883319 in KCNN3 and rs610277 in F3 were associated with PTB-M. <strong>Conclusions.</strong> Our study identified polymorphisms potentially associated with specific clinical subtypes of PTB in this Latin American population. These results could suggest a specific role of such genes in the mechanisms involved in each clinical subtype. Further studies are required to confirm our results and to determine the role of these genes in the pathophysiology of clinical subtypes.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://digital.cic.gba.gob.ar/handle/11746/6847
url https://digital.cic.gba.gob.ar/handle/11746/6847
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:CIC Digital (CICBA)
instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron:CICBA
reponame_str CIC Digital (CICBA)
collection CIC Digital (CICBA)
instname_str Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
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repository.name.fl_str_mv CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
repository.mail.fl_str_mv marisa.degiusti@sedici.unlp.edu.ar
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