Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory

Autores
Maldonado, H.; Romano, A.; Tomsic, D.
Año de publicación
1997
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed context, stimulus frequency and circadian phase specificity. A strong training protocol (STP) (≥15 trials, intertriai interval (ITI) of 171 s) invariably yielded LTH, while a weak training protocol (WTP) (≤10 trials, ITI = 171 s) invariably failed. STP was used with a presumably amnestic agent and WTP with a presumably hypermnestic agent. Remarkably, systemic administration of low doses was effective, which is likely to be due to the lack of an endothelial blood-brain barrier. LTH was blocked by inhibitors of protein and RNA synthesis, enhanced by protein kinase A (PKA) activators and reduced by PKA inhibitors, facilitated by angiotensin II and IV and disrupted by saralasin. The presence of angiotensins and related compounds in the crab brain was demonstrated. Diverse results suggest that LTH includes two components: an initial memory produced by spaced training and mainly expressed at an initial phase of testing, and a retraining memory produced by massed training and expressed at a later phase of testing (retraining). The initial memory would be associative, context specific and sensitive to cycloheximide, while the retraining memory would be nonassociative, context independent and insensitive to cycloheximide.
Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Tomsic, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
Braz. J. Med. Biol. Res. 1997;30(7):813-826
Materia
Angiotensin
Cycloheximide
Massed training
Memory
PKA
Spaced training
Chasmagnathus
Decapoda (Crustacea)
Iti
animal
animal behavior
biological model
Brachyura
habituation
memory
physiology
review
Animals
Behavior, Animal
Brachyura
Habituation, Psychophysiologic
Memory
Models, Biological
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_0100879X_v30_n7_p813_Maldonado

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oai_identifier_str paperaa:paper_0100879X_v30_n7_p813_Maldonado
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memoryMaldonado, H.Romano, A.Tomsic, D.AngiotensinCycloheximideMassed trainingMemoryPKASpaced trainingChasmagnathusDecapoda (Crustacea)Itianimalanimal behaviorbiological modelBrachyurahabituationmemoryphysiologyreviewAnimalsBehavior, AnimalBrachyuraHabituation, PsychophysiologicMemoryModels, BiologicalA decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed context, stimulus frequency and circadian phase specificity. A strong training protocol (STP) (≥15 trials, intertriai interval (ITI) of 171 s) invariably yielded LTH, while a weak training protocol (WTP) (≤10 trials, ITI = 171 s) invariably failed. STP was used with a presumably amnestic agent and WTP with a presumably hypermnestic agent. Remarkably, systemic administration of low doses was effective, which is likely to be due to the lack of an endothelial blood-brain barrier. LTH was blocked by inhibitors of protein and RNA synthesis, enhanced by protein kinase A (PKA) activators and reduced by PKA inhibitors, facilitated by angiotensin II and IV and disrupted by saralasin. The presence of angiotensins and related compounds in the crab brain was demonstrated. Diverse results suggest that LTH includes two components: an initial memory produced by spaced training and mainly expressed at an initial phase of testing, and a retraining memory produced by massed training and expressed at a later phase of testing (retraining). The initial memory would be associative, context specific and sensitive to cycloheximide, while the retraining memory would be nonassociative, context independent and insensitive to cycloheximide.Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Tomsic, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.1997info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_0100879X_v30_n7_p813_MaldonadoBraz. J. Med. Biol. Res. 1997;30(7):813-826reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:42:49Zpaperaa:paper_0100879X_v30_n7_p813_MaldonadoInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:42:50.769Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
title Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
spellingShingle Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
Maldonado, H.
Angiotensin
Cycloheximide
Massed training
Memory
PKA
Spaced training
Chasmagnathus
Decapoda (Crustacea)
Iti
animal
animal behavior
biological model
Brachyura
habituation
memory
physiology
review
Animals
Behavior, Animal
Brachyura
Habituation, Psychophysiologic
Memory
Models, Biological
title_short Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
title_full Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
title_fullStr Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
title_full_unstemmed Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
title_sort Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
dc.creator.none.fl_str_mv Maldonado, H.
Romano, A.
Tomsic, D.
author Maldonado, H.
author_facet Maldonado, H.
Romano, A.
Tomsic, D.
author_role author
author2 Romano, A.
Tomsic, D.
author2_role author
author
dc.subject.none.fl_str_mv Angiotensin
Cycloheximide
Massed training
Memory
PKA
Spaced training
Chasmagnathus
Decapoda (Crustacea)
Iti
animal
animal behavior
biological model
Brachyura
habituation
memory
physiology
review
Animals
Behavior, Animal
Brachyura
Habituation, Psychophysiologic
Memory
Models, Biological
topic Angiotensin
Cycloheximide
Massed training
Memory
PKA
Spaced training
Chasmagnathus
Decapoda (Crustacea)
Iti
animal
animal behavior
biological model
Brachyura
habituation
memory
physiology
review
Animals
Behavior, Animal
Brachyura
Habituation, Psychophysiologic
Memory
Models, Biological
dc.description.none.fl_txt_mv A decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed context, stimulus frequency and circadian phase specificity. A strong training protocol (STP) (≥15 trials, intertriai interval (ITI) of 171 s) invariably yielded LTH, while a weak training protocol (WTP) (≤10 trials, ITI = 171 s) invariably failed. STP was used with a presumably amnestic agent and WTP with a presumably hypermnestic agent. Remarkably, systemic administration of low doses was effective, which is likely to be due to the lack of an endothelial blood-brain barrier. LTH was blocked by inhibitors of protein and RNA synthesis, enhanced by protein kinase A (PKA) activators and reduced by PKA inhibitors, facilitated by angiotensin II and IV and disrupted by saralasin. The presence of angiotensins and related compounds in the crab brain was demonstrated. Diverse results suggest that LTH includes two components: an initial memory produced by spaced training and mainly expressed at an initial phase of testing, and a retraining memory produced by massed training and expressed at a later phase of testing (retraining). The initial memory would be associative, context specific and sensitive to cycloheximide, while the retraining memory would be nonassociative, context independent and insensitive to cycloheximide.
Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Tomsic, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description A decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed context, stimulus frequency and circadian phase specificity. A strong training protocol (STP) (≥15 trials, intertriai interval (ITI) of 171 s) invariably yielded LTH, while a weak training protocol (WTP) (≤10 trials, ITI = 171 s) invariably failed. STP was used with a presumably amnestic agent and WTP with a presumably hypermnestic agent. Remarkably, systemic administration of low doses was effective, which is likely to be due to the lack of an endothelial blood-brain barrier. LTH was blocked by inhibitors of protein and RNA synthesis, enhanced by protein kinase A (PKA) activators and reduced by PKA inhibitors, facilitated by angiotensin II and IV and disrupted by saralasin. The presence of angiotensins and related compounds in the crab brain was demonstrated. Diverse results suggest that LTH includes two components: an initial memory produced by spaced training and mainly expressed at an initial phase of testing, and a retraining memory produced by massed training and expressed at a later phase of testing (retraining). The initial memory would be associative, context specific and sensitive to cycloheximide, while the retraining memory would be nonassociative, context independent and insensitive to cycloheximide.
publishDate 1997
dc.date.none.fl_str_mv 1997
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_0100879X_v30_n7_p813_Maldonado
url http://hdl.handle.net/20.500.12110/paper_0100879X_v30_n7_p813_Maldonado
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Braz. J. Med. Biol. Res. 1997;30(7):813-826
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
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