Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory
- Autores
- Maldonado, H.; Romano, A.; Tomsic, D.
- Año de publicación
- 1997
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed context, stimulus frequency and circadian phase specificity. A strong training protocol (STP) (≥15 trials, intertriai interval (ITI) of 171 s) invariably yielded LTH, while a weak training protocol (WTP) (≤10 trials, ITI = 171 s) invariably failed. STP was used with a presumably amnestic agent and WTP with a presumably hypermnestic agent. Remarkably, systemic administration of low doses was effective, which is likely to be due to the lack of an endothelial blood-brain barrier. LTH was blocked by inhibitors of protein and RNA synthesis, enhanced by protein kinase A (PKA) activators and reduced by PKA inhibitors, facilitated by angiotensin II and IV and disrupted by saralasin. The presence of angiotensins and related compounds in the crab brain was demonstrated. Diverse results suggest that LTH includes two components: an initial memory produced by spaced training and mainly expressed at an initial phase of testing, and a retraining memory produced by massed training and expressed at a later phase of testing (retraining). The initial memory would be associative, context specific and sensitive to cycloheximide, while the retraining memory would be nonassociative, context independent and insensitive to cycloheximide.
Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Tomsic, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. - Fuente
- Braz. J. Med. Biol. Res. 1997;30(7):813-826
- Materia
-
Angiotensin
Cycloheximide
Massed training
Memory
PKA
Spaced training
Chasmagnathus
Decapoda (Crustacea)
Iti
animal
animal behavior
biological model
Brachyura
habituation
memory
physiology
review
Animals
Behavior, Animal
Brachyura
Habituation, Psychophysiologic
Memory
Models, Biological - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/2.5/ar
- Repositorio
- Institución
- Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
- OAI Identificador
- paperaa:paper_0100879X_v30_n7_p813_Maldonado
Ver los metadatos del registro completo
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Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memoryMaldonado, H.Romano, A.Tomsic, D.AngiotensinCycloheximideMassed trainingMemoryPKASpaced trainingChasmagnathusDecapoda (Crustacea)Itianimalanimal behaviorbiological modelBrachyurahabituationmemoryphysiologyreviewAnimalsBehavior, AnimalBrachyuraHabituation, PsychophysiologicMemoryModels, BiologicalA decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed context, stimulus frequency and circadian phase specificity. A strong training protocol (STP) (≥15 trials, intertriai interval (ITI) of 171 s) invariably yielded LTH, while a weak training protocol (WTP) (≤10 trials, ITI = 171 s) invariably failed. STP was used with a presumably amnestic agent and WTP with a presumably hypermnestic agent. Remarkably, systemic administration of low doses was effective, which is likely to be due to the lack of an endothelial blood-brain barrier. LTH was blocked by inhibitors of protein and RNA synthesis, enhanced by protein kinase A (PKA) activators and reduced by PKA inhibitors, facilitated by angiotensin II and IV and disrupted by saralasin. The presence of angiotensins and related compounds in the crab brain was demonstrated. Diverse results suggest that LTH includes two components: an initial memory produced by spaced training and mainly expressed at an initial phase of testing, and a retraining memory produced by massed training and expressed at a later phase of testing (retraining). The initial memory would be associative, context specific and sensitive to cycloheximide, while the retraining memory would be nonassociative, context independent and insensitive to cycloheximide.Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Tomsic, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.1997info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_0100879X_v30_n7_p813_MaldonadoBraz. J. Med. Biol. Res. 1997;30(7):813-826reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:42:49Zpaperaa:paper_0100879X_v30_n7_p813_MaldonadoInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:42:50.769Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse |
dc.title.none.fl_str_mv |
Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory |
title |
Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory |
spellingShingle |
Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory Maldonado, H. Angiotensin Cycloheximide Massed training Memory PKA Spaced training Chasmagnathus Decapoda (Crustacea) Iti animal animal behavior biological model Brachyura habituation memory physiology review Animals Behavior, Animal Brachyura Habituation, Psychophysiologic Memory Models, Biological |
title_short |
Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory |
title_full |
Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory |
title_fullStr |
Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory |
title_full_unstemmed |
Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory |
title_sort |
Long-term habituation (LTH) in the crab Chasmagnathus: A model for behavioral and mechanistic studies of memory |
dc.creator.none.fl_str_mv |
Maldonado, H. Romano, A. Tomsic, D. |
author |
Maldonado, H. |
author_facet |
Maldonado, H. Romano, A. Tomsic, D. |
author_role |
author |
author2 |
Romano, A. Tomsic, D. |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Angiotensin Cycloheximide Massed training Memory PKA Spaced training Chasmagnathus Decapoda (Crustacea) Iti animal animal behavior biological model Brachyura habituation memory physiology review Animals Behavior, Animal Brachyura Habituation, Psychophysiologic Memory Models, Biological |
topic |
Angiotensin Cycloheximide Massed training Memory PKA Spaced training Chasmagnathus Decapoda (Crustacea) Iti animal animal behavior biological model Brachyura habituation memory physiology review Animals Behavior, Animal Brachyura Habituation, Psychophysiologic Memory Models, Biological |
dc.description.none.fl_txt_mv |
A decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed context, stimulus frequency and circadian phase specificity. A strong training protocol (STP) (≥15 trials, intertriai interval (ITI) of 171 s) invariably yielded LTH, while a weak training protocol (WTP) (≤10 trials, ITI = 171 s) invariably failed. STP was used with a presumably amnestic agent and WTP with a presumably hypermnestic agent. Remarkably, systemic administration of low doses was effective, which is likely to be due to the lack of an endothelial blood-brain barrier. LTH was blocked by inhibitors of protein and RNA synthesis, enhanced by protein kinase A (PKA) activators and reduced by PKA inhibitors, facilitated by angiotensin II and IV and disrupted by saralasin. The presence of angiotensins and related compounds in the crab brain was demonstrated. Diverse results suggest that LTH includes two components: an initial memory produced by spaced training and mainly expressed at an initial phase of testing, and a retraining memory produced by massed training and expressed at a later phase of testing (retraining). The initial memory would be associative, context specific and sensitive to cycloheximide, while the retraining memory would be nonassociative, context independent and insensitive to cycloheximide. Fil:Romano, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tomsic, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
description |
A decade of studies on long-term habituation (LTH) in the crab Chasmagnathus is reviewed. Upon sudden presentation of a passing object overhead, the crab reacts with an escape response that habituates promptly and for at least five days. LTH proved to be an instance of associative memory and showed context, stimulus frequency and circadian phase specificity. A strong training protocol (STP) (≥15 trials, intertriai interval (ITI) of 171 s) invariably yielded LTH, while a weak training protocol (WTP) (≤10 trials, ITI = 171 s) invariably failed. STP was used with a presumably amnestic agent and WTP with a presumably hypermnestic agent. Remarkably, systemic administration of low doses was effective, which is likely to be due to the lack of an endothelial blood-brain barrier. LTH was blocked by inhibitors of protein and RNA synthesis, enhanced by protein kinase A (PKA) activators and reduced by PKA inhibitors, facilitated by angiotensin II and IV and disrupted by saralasin. The presence of angiotensins and related compounds in the crab brain was demonstrated. Diverse results suggest that LTH includes two components: an initial memory produced by spaced training and mainly expressed at an initial phase of testing, and a retraining memory produced by massed training and expressed at a later phase of testing (retraining). The initial memory would be associative, context specific and sensitive to cycloheximide, while the retraining memory would be nonassociative, context independent and insensitive to cycloheximide. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12110/paper_0100879X_v30_n7_p813_Maldonado |
url |
http://hdl.handle.net/20.500.12110/paper_0100879X_v30_n7_p813_Maldonado |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/2.5/ar |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Braz. J. Med. Biol. Res. 1997;30(7):813-826 reponame:Biblioteca Digital (UBA-FCEN) instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales instacron:UBA-FCEN |
reponame_str |
Biblioteca Digital (UBA-FCEN) |
collection |
Biblioteca Digital (UBA-FCEN) |
instname_str |
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
instacron_str |
UBA-FCEN |
institution |
UBA-FCEN |
repository.name.fl_str_mv |
Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
repository.mail.fl_str_mv |
ana@bl.fcen.uba.ar |
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1844618733240188928 |
score |
13.070432 |