Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánico

Autores
Iglesias, Luis Emilio
Año de publicación
1996
Idioma
español castellano
Tipo de recurso
tesis doctoral
Estado
versión publicada
Colaborador/a o director/a de tesis
Gros, Eduardo Gervasio
Baldessari, Alicia
Descripción
Various bi- and polifunctional hydroxyalkanethiols were chemospecificallyacylated to O-acylesters by lipase-catalyzed transesterifications in organic media. Inaddition, hydroxyalkanethiols with two hydroxyl groups exhibited regiospecificity orregioselectivity, depending on the nature of both the substrate and the lipase. As the chainlength of the α,ω-hydroxyalkanethiol increased, the reaction was limited to smaller acylmoieties. Experimental conditions under which enzymatic acylations were carried out andtheir results are presented and discussed. Biocatalyzed transesterifications allowed thepreparation of twenty-four new esters. The preparation of some α,ω-hydroxyalkanethiolsand the mass spectra of substrates and products are also presented and discussed.
Fil: Iglesias, Luis Emilio. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Materia
LIPASES
ORGANIC MEDIA
HYDROXYALKANETHIOLS
SELECTIVE ACYLATION
TRANSESTERIFICATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
tesis:tesis_n2856_Iglesias
Acceder
id BDUBAFCEN_3f837d9a44901107c7d905200d03e0e0
oai_identifier_str tesis:tesis_n2856_Iglesias
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánicoLipase-catalyzed chemoselective acylation of hydroxyalkanethiols in organic mediaIglesias, Luis EmilioLIPASESORGANIC MEDIAHYDROXYALKANETHIOLSSELECTIVE ACYLATIONTRANSESTERIFICATIONVarious bi- and polifunctional hydroxyalkanethiols were chemospecificallyacylated to O-acylesters by lipase-catalyzed transesterifications in organic media. Inaddition, hydroxyalkanethiols with two hydroxyl groups exhibited regiospecificity orregioselectivity, depending on the nature of both the substrate and the lipase. As the chainlength of the α,ω-hydroxyalkanethiol increased, the reaction was limited to smaller acylmoieties. Experimental conditions under which enzymatic acylations were carried out andtheir results are presented and discussed. Biocatalyzed transesterifications allowed thepreparation of twenty-four new esters. The preparation of some α,ω-hydroxyalkanethiolsand the mass spectra of substrates and products are also presented and discussed.Fil: Iglesias, Luis Emilio. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Universidad de Buenos Aires. Facultad de Ciencias Exactas y NaturalesGros, Eduardo GervasioBaldessari, Alicia1996info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_db06info:ar-repo/semantics/tesisDoctoralapplication/pdfhttps://hdl.handle.net/20.500.12110/tesis_n2856_Iglesiasspainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/arreponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCEN2025-09-29T13:42:43Ztesis:tesis_n2856_IglesiasInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:42:44.877Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánico
Lipase-catalyzed chemoselective acylation of hydroxyalkanethiols in organic media
title Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánico
spellingShingle Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánico
Iglesias, Luis Emilio
LIPASES
ORGANIC MEDIA
HYDROXYALKANETHIOLS
SELECTIVE ACYLATION
TRANSESTERIFICATION
title_short Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánico
title_full Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánico
title_fullStr Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánico
title_full_unstemmed Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánico
title_sort Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánico
dc.creator.none.fl_str_mv Iglesias, Luis Emilio
author Iglesias, Luis Emilio
author_facet Iglesias, Luis Emilio
author_role author
dc.contributor.none.fl_str_mv Gros, Eduardo Gervasio
Baldessari, Alicia
dc.subject.none.fl_str_mv LIPASES
ORGANIC MEDIA
HYDROXYALKANETHIOLS
SELECTIVE ACYLATION
TRANSESTERIFICATION
topic LIPASES
ORGANIC MEDIA
HYDROXYALKANETHIOLS
SELECTIVE ACYLATION
TRANSESTERIFICATION
dc.description.none.fl_txt_mv Various bi- and polifunctional hydroxyalkanethiols were chemospecificallyacylated to O-acylesters by lipase-catalyzed transesterifications in organic media. Inaddition, hydroxyalkanethiols with two hydroxyl groups exhibited regiospecificity orregioselectivity, depending on the nature of both the substrate and the lipase. As the chainlength of the α,ω-hydroxyalkanethiol increased, the reaction was limited to smaller acylmoieties. Experimental conditions under which enzymatic acylations were carried out andtheir results are presented and discussed. Biocatalyzed transesterifications allowed thepreparation of twenty-four new esters. The preparation of some α,ω-hydroxyalkanethiolsand the mass spectra of substrates and products are also presented and discussed.
Fil: Iglesias, Luis Emilio. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description Various bi- and polifunctional hydroxyalkanethiols were chemospecificallyacylated to O-acylesters by lipase-catalyzed transesterifications in organic media. Inaddition, hydroxyalkanethiols with two hydroxyl groups exhibited regiospecificity orregioselectivity, depending on the nature of both the substrate and the lipase. As the chainlength of the α,ω-hydroxyalkanethiol increased, the reaction was limited to smaller acylmoieties. Experimental conditions under which enzymatic acylations were carried out andtheir results are presented and discussed. Biocatalyzed transesterifications allowed thepreparation of twenty-four new esters. The preparation of some α,ω-hydroxyalkanethiolsand the mass spectra of substrates and products are also presented and discussed.
publishDate 1996
dc.date.none.fl_str_mv 1996
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_db06
info:ar-repo/semantics/tesisDoctoral
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12110/tesis_n2856_Iglesias
url https://hdl.handle.net/20.500.12110/tesis_n2856_Iglesias
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales
publisher.none.fl_str_mv Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales
dc.source.none.fl_str_mv reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
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score 13.070432

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