Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
- Autores
- Del C. Batlle, A.M.; Bustos, N.L.; Stella, A.M.; Wider, E.A.; Conti, H.A.; Mendez, A.
- Año de publicación
- 1983
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- 1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in the patient's erythrocyte dehydratase activity was detected 1 hr after enzyme administration, reaching its maximum and nearly normal level 2 days later, values remained unchanged for a week, to slowly diminish after 2 weeks of initiated the treatment, and finally recovered activity was kept practically leveled off for weeks. 4. 4. This novel therapeutic trial produced complete improvement both clinical and biochemical, showing that enzyme infusion has been beneficial and can be safely and successfully used in the treatment of human lead intoxication. © 1983.
Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Bustos, N.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. - Fuente
- Int. J. Biochem. 1983;15(10):1261-1265
- Materia
-
lead
porphobilinogen synthase
blood and hemopoietic system
case report
drug therapy
drug toxicity
enzyme therapy
erythrocyte ghost
human
intoxication
lead poisoning
porphyria
therapy
Adult
Coproporphyrins
Erythrocyte Membrane
Humans
Injections, Intravenous
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
Uroporphyrins - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/2.5/ar
- Repositorio
- Institución
- Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
- OAI Identificador
- paperaa:paper_0020711X_v15_n10_p1261_DelCBatlle
Ver los metadatos del registro completo
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Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghostsDel C. Batlle, A.M.Bustos, N.L.Stella, A.M.Wider, E.A.Conti, H.A.Mendez, A.leadporphobilinogen synthaseblood and hemopoietic systemcase reportdrug therapydrug toxicityenzyme therapyerythrocyte ghosthumanintoxicationlead poisoningporphyriatherapyAdultCoproporphyrinsErythrocyte MembraneHumansInjections, IntravenousLead PoisoningMalePorphobilinogen SynthasePorphyrinsUroporphyrins1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in the patient's erythrocyte dehydratase activity was detected 1 hr after enzyme administration, reaching its maximum and nearly normal level 2 days later, values remained unchanged for a week, to slowly diminish after 2 weeks of initiated the treatment, and finally recovered activity was kept practically leveled off for weeks. 4. 4. This novel therapeutic trial produced complete improvement both clinical and biochemical, showing that enzyme infusion has been beneficial and can be safely and successfully used in the treatment of human lead intoxication. © 1983.Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Bustos, N.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.1983info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_0020711X_v15_n10_p1261_DelCBatlleInt. J. Biochem. 1983;15(10):1261-1265reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:42:57Zpaperaa:paper_0020711X_v15_n10_p1261_DelCBatlleInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:42:58.844Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse |
dc.title.none.fl_str_mv |
Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts |
title |
Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts |
spellingShingle |
Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts Del C. Batlle, A.M. lead porphobilinogen synthase blood and hemopoietic system case report drug therapy drug toxicity enzyme therapy erythrocyte ghost human intoxication lead poisoning porphyria therapy Adult Coproporphyrins Erythrocyte Membrane Humans Injections, Intravenous Lead Poisoning Male Porphobilinogen Synthase Porphyrins Uroporphyrins |
title_short |
Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts |
title_full |
Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts |
title_fullStr |
Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts |
title_full_unstemmed |
Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts |
title_sort |
Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts |
dc.creator.none.fl_str_mv |
Del C. Batlle, A.M. Bustos, N.L. Stella, A.M. Wider, E.A. Conti, H.A. Mendez, A. |
author |
Del C. Batlle, A.M. |
author_facet |
Del C. Batlle, A.M. Bustos, N.L. Stella, A.M. Wider, E.A. Conti, H.A. Mendez, A. |
author_role |
author |
author2 |
Bustos, N.L. Stella, A.M. Wider, E.A. Conti, H.A. Mendez, A. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
lead porphobilinogen synthase blood and hemopoietic system case report drug therapy drug toxicity enzyme therapy erythrocyte ghost human intoxication lead poisoning porphyria therapy Adult Coproporphyrins Erythrocyte Membrane Humans Injections, Intravenous Lead Poisoning Male Porphobilinogen Synthase Porphyrins Uroporphyrins |
topic |
lead porphobilinogen synthase blood and hemopoietic system case report drug therapy drug toxicity enzyme therapy erythrocyte ghost human intoxication lead poisoning porphyria therapy Adult Coproporphyrins Erythrocyte Membrane Humans Injections, Intravenous Lead Poisoning Male Porphobilinogen Synthase Porphyrins Uroporphyrins |
dc.description.none.fl_txt_mv |
1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in the patient's erythrocyte dehydratase activity was detected 1 hr after enzyme administration, reaching its maximum and nearly normal level 2 days later, values remained unchanged for a week, to slowly diminish after 2 weeks of initiated the treatment, and finally recovered activity was kept practically leveled off for weeks. 4. 4. This novel therapeutic trial produced complete improvement both clinical and biochemical, showing that enzyme infusion has been beneficial and can be safely and successfully used in the treatment of human lead intoxication. © 1983. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bustos, N.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
description |
1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in the patient's erythrocyte dehydratase activity was detected 1 hr after enzyme administration, reaching its maximum and nearly normal level 2 days later, values remained unchanged for a week, to slowly diminish after 2 weeks of initiated the treatment, and finally recovered activity was kept practically leveled off for weeks. 4. 4. This novel therapeutic trial produced complete improvement both clinical and biochemical, showing that enzyme infusion has been beneficial and can be safely and successfully used in the treatment of human lead intoxication. © 1983. |
publishDate |
1983 |
dc.date.none.fl_str_mv |
1983 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12110/paper_0020711X_v15_n10_p1261_DelCBatlle |
url |
http://hdl.handle.net/20.500.12110/paper_0020711X_v15_n10_p1261_DelCBatlle |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/2.5/ar |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Int. J. Biochem. 1983;15(10):1261-1265 reponame:Biblioteca Digital (UBA-FCEN) instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales instacron:UBA-FCEN |
reponame_str |
Biblioteca Digital (UBA-FCEN) |
collection |
Biblioteca Digital (UBA-FCEN) |
instname_str |
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
instacron_str |
UBA-FCEN |
institution |
UBA-FCEN |
repository.name.fl_str_mv |
Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
repository.mail.fl_str_mv |
ana@bl.fcen.uba.ar |
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1844618735924543488 |
score |
13.070432 |