Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts

Autores
Del C. Batlle, A.M.; Bustos, N.L.; Stella, A.M.; Wider, E.A.; Conti, H.A.; Mendez, A.
Año de publicación
1983
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in the patient's erythrocyte dehydratase activity was detected 1 hr after enzyme administration, reaching its maximum and nearly normal level 2 days later, values remained unchanged for a week, to slowly diminish after 2 weeks of initiated the treatment, and finally recovered activity was kept practically leveled off for weeks. 4. 4. This novel therapeutic trial produced complete improvement both clinical and biochemical, showing that enzyme infusion has been beneficial and can be safely and successfully used in the treatment of human lead intoxication. © 1983.
Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Bustos, N.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
Int. J. Biochem. 1983;15(10):1261-1265
Materia
lead
porphobilinogen synthase
blood and hemopoietic system
case report
drug therapy
drug toxicity
enzyme therapy
erythrocyte ghost
human
intoxication
lead poisoning
porphyria
therapy
Adult
Coproporphyrins
Erythrocyte Membrane
Humans
Injections, Intravenous
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
Uroporphyrins
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_0020711X_v15_n10_p1261_DelCBatlle
Acceder
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oai_identifier_str paperaa:paper_0020711X_v15_n10_p1261_DelCBatlle
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghostsDel C. Batlle, A.M.Bustos, N.L.Stella, A.M.Wider, E.A.Conti, H.A.Mendez, A.leadporphobilinogen synthaseblood and hemopoietic systemcase reportdrug therapydrug toxicityenzyme therapyerythrocyte ghosthumanintoxicationlead poisoningporphyriatherapyAdultCoproporphyrinsErythrocyte MembraneHumansInjections, IntravenousLead PoisoningMalePorphobilinogen SynthasePorphyrinsUroporphyrins1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in the patient's erythrocyte dehydratase activity was detected 1 hr after enzyme administration, reaching its maximum and nearly normal level 2 days later, values remained unchanged for a week, to slowly diminish after 2 weeks of initiated the treatment, and finally recovered activity was kept practically leveled off for weeks. 4. 4. This novel therapeutic trial produced complete improvement both clinical and biochemical, showing that enzyme infusion has been beneficial and can be safely and successfully used in the treatment of human lead intoxication. © 1983.Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Bustos, N.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.1983info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_0020711X_v15_n10_p1261_DelCBatlleInt. J. Biochem. 1983;15(10):1261-1265reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-10-23T11:18:21Zpaperaa:paper_0020711X_v15_n10_p1261_DelCBatlleInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-10-23 11:18:23.2Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
title Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
spellingShingle Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
Del C. Batlle, A.M.
lead
porphobilinogen synthase
blood and hemopoietic system
case report
drug therapy
drug toxicity
enzyme therapy
erythrocyte ghost
human
intoxication
lead poisoning
porphyria
therapy
Adult
Coproporphyrins
Erythrocyte Membrane
Humans
Injections, Intravenous
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
Uroporphyrins
title_short Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
title_full Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
title_fullStr Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
title_full_unstemmed Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
title_sort Enzyme replacement therapy in porphyrias-IV. First successful human clinical trial of δ-aminolevulinate dehydratase-loaded erythrocyte ghosts
dc.creator.none.fl_str_mv Del C. Batlle, A.M.
Bustos, N.L.
Stella, A.M.
Wider, E.A.
Conti, H.A.
Mendez, A.
author Del C. Batlle, A.M.
author_facet Del C. Batlle, A.M.
Bustos, N.L.
Stella, A.M.
Wider, E.A.
Conti, H.A.
Mendez, A.
author_role author
author2 Bustos, N.L.
Stella, A.M.
Wider, E.A.
Conti, H.A.
Mendez, A.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv lead
porphobilinogen synthase
blood and hemopoietic system
case report
drug therapy
drug toxicity
enzyme therapy
erythrocyte ghost
human
intoxication
lead poisoning
porphyria
therapy
Adult
Coproporphyrins
Erythrocyte Membrane
Humans
Injections, Intravenous
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
Uroporphyrins
topic lead
porphobilinogen synthase
blood and hemopoietic system
case report
drug therapy
drug toxicity
enzyme therapy
erythrocyte ghost
human
intoxication
lead poisoning
porphyria
therapy
Adult
Coproporphyrins
Erythrocyte Membrane
Humans
Injections, Intravenous
Lead Poisoning
Male
Porphobilinogen Synthase
Porphyrins
Uroporphyrins
dc.description.none.fl_txt_mv 1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in the patient's erythrocyte dehydratase activity was detected 1 hr after enzyme administration, reaching its maximum and nearly normal level 2 days later, values remained unchanged for a week, to slowly diminish after 2 weeks of initiated the treatment, and finally recovered activity was kept practically leveled off for weeks. 4. 4. This novel therapeutic trial produced complete improvement both clinical and biochemical, showing that enzyme infusion has been beneficial and can be safely and successfully used in the treatment of human lead intoxication. © 1983.
Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Bustos, N.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Stella, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description 1. 1. A patient with chronic lead intoxication was treated with only one course of highly purified human blood aminolaevulinate dehydratase entrapped in autologous erythrocyte ghosts given intravenously. 2. 2. No untoward effects were observed during or after infusion. 3. 3. An immediate increase in the patient's erythrocyte dehydratase activity was detected 1 hr after enzyme administration, reaching its maximum and nearly normal level 2 days later, values remained unchanged for a week, to slowly diminish after 2 weeks of initiated the treatment, and finally recovered activity was kept practically leveled off for weeks. 4. 4. This novel therapeutic trial produced complete improvement both clinical and biochemical, showing that enzyme infusion has been beneficial and can be safely and successfully used in the treatment of human lead intoxication. © 1983.
publishDate 1983
dc.date.none.fl_str_mv 1983
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_0020711X_v15_n10_p1261_DelCBatlle
url http://hdl.handle.net/20.500.12110/paper_0020711X_v15_n10_p1261_DelCBatlle
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Int. J. Biochem. 1983;15(10):1261-1265
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
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score 12.982451

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