Virucidal activity presence in Trichilia glabra leaves

Autores
Cella, M.; Riva, D.A.; Coulombié, F.C.; Mersich, S.E.
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Different immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were investigated. Methanolic fraction extracts were active against herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV), while no activity against poliovirus type 3 was observed. VSV was slightly more affected than HSV-1: 2.8 log10 reduction in VSV titer against 2.4 log10 reduction in HSV-1 titer when 0.25 mg/ml F2 fraction was tested and a reduction of 2.7 log10 in VSV virus titer and of 1.5 log10 in HSV-1 virus titer was observed when 0.25 mg/ml F3 fraction was tested. Results obtained in this work suggest a potential pharmaceutical use of TG extract components.
Fil:Cella, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Riva, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Coulombié, F.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Mersich, S.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
Rev. Argent. Microbiol. 2004;36(3):136-138
Materia
Methanolic extracts
Trichilia glabra leaves
Virucidal activity
chloroform
methanol
plant extract
Trichilia glabra extract
unclassified drug
antiinflammatory activity
antiviral activity
article
controlled study
Herpes simplex virus 1
immunomodulation
in vivo study
medicinal plant
nonhuman
plant leaf
Poliomyelitis virus
Trichilia glabra
Vesicular stomatitis virus
virus infectivity
virus titration
Animals
Antiviral Agents
Cercopithecus aethiops
Chemical Fractionation
Chloroform
Herpesvirus 1, Human
Meliaceae
Methanol
Plant Extracts
Plant Leaves
Poliovirus
Vero Cells
Vesicular stomatitis-Indiana virus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_03257541_v36_n3_p136_Cella
Acceder
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oai_identifier_str paperaa:paper_03257541_v36_n3_p136_Cella
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Virucidal activity presence in Trichilia glabra leavesCella, M.Riva, D.A.Coulombié, F.C.Mersich, S.E.Methanolic extractsTrichilia glabra leavesVirucidal activitychloroformmethanolplant extractTrichilia glabra extractunclassified drugantiinflammatory activityantiviral activityarticlecontrolled studyHerpes simplex virus 1immunomodulationin vivo studymedicinal plantnonhumanplant leafPoliomyelitis virusTrichilia glabraVesicular stomatitis virusvirus infectivityvirus titrationAnimalsAntiviral AgentsCercopithecus aethiopsChemical FractionationChloroformHerpesvirus 1, HumanMeliaceaeMethanolPlant ExtractsPlant LeavesPoliovirusVero CellsVesicular stomatitis-Indiana virusDifferent immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were investigated. Methanolic fraction extracts were active against herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV), while no activity against poliovirus type 3 was observed. VSV was slightly more affected than HSV-1: 2.8 log10 reduction in VSV titer against 2.4 log10 reduction in HSV-1 titer when 0.25 mg/ml F2 fraction was tested and a reduction of 2.7 log10 in VSV virus titer and of 1.5 log10 in HSV-1 virus titer was observed when 0.25 mg/ml F3 fraction was tested. Results obtained in this work suggest a potential pharmaceutical use of TG extract components.Fil:Cella, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Riva, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Coulombié, F.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Mersich, S.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2004info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_03257541_v36_n3_p136_CellaRev. Argent. Microbiol. 2004;36(3):136-138reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-18T10:09:13Zpaperaa:paper_03257541_v36_n3_p136_CellaInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-18 10:09:15.185Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Virucidal activity presence in Trichilia glabra leaves
title Virucidal activity presence in Trichilia glabra leaves
spellingShingle Virucidal activity presence in Trichilia glabra leaves
Cella, M.
Methanolic extracts
Trichilia glabra leaves
Virucidal activity
chloroform
methanol
plant extract
Trichilia glabra extract
unclassified drug
antiinflammatory activity
antiviral activity
article
controlled study
Herpes simplex virus 1
immunomodulation
in vivo study
medicinal plant
nonhuman
plant leaf
Poliomyelitis virus
Trichilia glabra
Vesicular stomatitis virus
virus infectivity
virus titration
Animals
Antiviral Agents
Cercopithecus aethiops
Chemical Fractionation
Chloroform
Herpesvirus 1, Human
Meliaceae
Methanol
Plant Extracts
Plant Leaves
Poliovirus
Vero Cells
Vesicular stomatitis-Indiana virus
title_short Virucidal activity presence in Trichilia glabra leaves
title_full Virucidal activity presence in Trichilia glabra leaves
title_fullStr Virucidal activity presence in Trichilia glabra leaves
title_full_unstemmed Virucidal activity presence in Trichilia glabra leaves
title_sort Virucidal activity presence in Trichilia glabra leaves
dc.creator.none.fl_str_mv Cella, M.
Riva, D.A.
Coulombié, F.C.
Mersich, S.E.
author Cella, M.
author_facet Cella, M.
Riva, D.A.
Coulombié, F.C.
Mersich, S.E.
author_role author
author2 Riva, D.A.
Coulombié, F.C.
Mersich, S.E.
author2_role author
author
author
dc.subject.none.fl_str_mv Methanolic extracts
Trichilia glabra leaves
Virucidal activity
chloroform
methanol
plant extract
Trichilia glabra extract
unclassified drug
antiinflammatory activity
antiviral activity
article
controlled study
Herpes simplex virus 1
immunomodulation
in vivo study
medicinal plant
nonhuman
plant leaf
Poliomyelitis virus
Trichilia glabra
Vesicular stomatitis virus
virus infectivity
virus titration
Animals
Antiviral Agents
Cercopithecus aethiops
Chemical Fractionation
Chloroform
Herpesvirus 1, Human
Meliaceae
Methanol
Plant Extracts
Plant Leaves
Poliovirus
Vero Cells
Vesicular stomatitis-Indiana virus
topic Methanolic extracts
Trichilia glabra leaves
Virucidal activity
chloroform
methanol
plant extract
Trichilia glabra extract
unclassified drug
antiinflammatory activity
antiviral activity
article
controlled study
Herpes simplex virus 1
immunomodulation
in vivo study
medicinal plant
nonhuman
plant leaf
Poliomyelitis virus
Trichilia glabra
Vesicular stomatitis virus
virus infectivity
virus titration
Animals
Antiviral Agents
Cercopithecus aethiops
Chemical Fractionation
Chloroform
Herpesvirus 1, Human
Meliaceae
Methanol
Plant Extracts
Plant Leaves
Poliovirus
Vero Cells
Vesicular stomatitis-Indiana virus
dc.description.none.fl_txt_mv Different immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were investigated. Methanolic fraction extracts were active against herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV), while no activity against poliovirus type 3 was observed. VSV was slightly more affected than HSV-1: 2.8 log10 reduction in VSV titer against 2.4 log10 reduction in HSV-1 titer when 0.25 mg/ml F2 fraction was tested and a reduction of 2.7 log10 in VSV virus titer and of 1.5 log10 in HSV-1 virus titer was observed when 0.25 mg/ml F3 fraction was tested. Results obtained in this work suggest a potential pharmaceutical use of TG extract components.
Fil:Cella, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Riva, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Coulombié, F.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Mersich, S.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description Different immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were investigated. Methanolic fraction extracts were active against herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV), while no activity against poliovirus type 3 was observed. VSV was slightly more affected than HSV-1: 2.8 log10 reduction in VSV titer against 2.4 log10 reduction in HSV-1 titer when 0.25 mg/ml F2 fraction was tested and a reduction of 2.7 log10 in VSV virus titer and of 1.5 log10 in HSV-1 virus titer was observed when 0.25 mg/ml F3 fraction was tested. Results obtained in this work suggest a potential pharmaceutical use of TG extract components.
publishDate 2004
dc.date.none.fl_str_mv 2004
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_03257541_v36_n3_p136_Cella
url http://hdl.handle.net/20.500.12110/paper_03257541_v36_n3_p136_Cella
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Rev. Argent. Microbiol. 2004;36(3):136-138
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
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score 13.000565

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