Publication Date: 2018.
Fungi are cosmopolitan organisms that grow in and adapt to a vast number of substrates and environments, and that can cause diseases in humans and animals, as well as in crops. The vast area and diverse geographical characteristics of Argentina, with the consequent climatic diversity make the country an important source of biological resources suitable for the search of new compounds. The aim of the present study was to describe the antifungal activity of extracts of Parastrephia quadrangularis, a species from northern Argentina, against Fusarium verticillioides M7075. Bio‐guided fractionation and MS/MS studies were conducted to elucidate the chemical structure of active compounds. The extracts exhibited a minimum inhibitory concentration among 118·74 and 250 μg ml−1 and the differences between the treatments and the inoculum control was 12·5–16·5 mm, respectively, in colony growth. Moreover, hyphae treated with the extracts stained blue with Evans blue, showed alterations in permeability of plasma membranes. HLPC‐MS analysis of active fractions revealed the presence of p‐coumaroyloxitremetone, and a derivate structure for another compound is proposed.
Instituto de Patobiología
Author affiliation: Di Ciaccio, Lucía Soledad. INTA. Instituto de Patobiología; Argentina
Author affiliation: Spotorno, Viviana Graciela. INTA. Instituto de Recursos Biológicos; Argentina
Author affiliation: Córdoba Estévez, M.M. Instituto Nacional de Tecnología Industrial. Laboratorio de desarrollo analítico y control de procesos; Argentina
Author affiliation: Ríos, Dante José. INTA. Estación Experimental Agropecuaria Abra Pampa. Agencia de Extensión Rural Abra Pampa; Argentina
Author affiliation: Fortunato, Renee Hersilia. INTA. Instituto de Recursos Biológicos; Argentina
Author affiliation: Salvat, Adriana Elisabeth. INTA. Instituto de Patobiología; Argentina
Repository: INTA Digital (INTA). Instituto Nacional de Tecnología Agropecuaria