Authors: Ramirez, Maria Soledad; Xie, Gang; Traglia, German Matias; Johnson, Shannon L.; Davenport, Karen W.; Van Duin, David; Ramazani, Azam; Perez, Federico; Jacobs, Michael R.; Sherratt, David J.; Bonomo, Robert A.; Chain, Patrick S. G.; Tolmasky, Marcelo E.
Publication Date: 2016.
Language: English.
Abstract:
Klebsiella pneumoniae has become one of the most dangerous causative agents of hospital infections due to the acquisition of resistance to carbapenems, one of the last resort families of antibiotics. Resistance is usually mediated by carbapenemases coded for by different classes of genes. A prolonged outbreak of carbapenem-resistant K. pneumoniae infections has been recently described in northeastern Ohio. Most strains isolated from patients during this outbreak belong to MLST sequence type 258 (ST258). To understand more about this outbreak two isolates (strains 140 and 677), one of them responsible for a fatal infection, were selected for genome comparison analyses. Whole genome map and sequence comparisons demonstrated that both strains are highly related showing 99% average nucleotide identity. However, the genomes differ at the so-called high heterogeneity zone (HHZ) and other minor regions. This study identifies the potential value of the HHZ as a potential marker for K. pneumoniae clinical and epidemiological studies.
Author affiliation: Ramirez, Maria Soledad. California State University Fullerton; Estados Unidos
Author affiliation: Xie, Gang. Los Alamos National High Magnetic Field Laboratory; Estados Unidos
Author affiliation: Traglia, German Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Author affiliation: Johnson, Shannon L.. Los Alamos National High Magnetic Field Laboratory; Estados Unidos
Author affiliation: Davenport, Karen W.. Los Alamos National High Magnetic Field Laboratory; Estados Unidos
Author affiliation: Van Duin, David. University of North Carolina; Estados Unidos
Author affiliation: Ramazani, Azam. California State University Fullerton; Estados Unidos. University of Oxford; Reino Unido
Author affiliation: Perez, Federico. Louis Stokes Cleveland Department of Veterans Affairs Medical Center; Estados Unidos
Author affiliation: Jacobs, Michael R.. Case Western Reserve University School of Medicine; Estados Unidos
Author affiliation: Sherratt, David J.. University of Oxford; Reino Unido
Author affiliation: Bonomo, Robert A.. Louis Stokes Cleveland Department of Veterans Affairs Medical Center; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos
Author affiliation: Chain, Patrick S. G.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Author affiliation: Tolmasky, Marcelo E.. California State University Fullerton; Estados Unidos
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas