Publication Date: 2016.
Affective temperament has been suggested as a potential mediator of the effect between genetic predisposition and neurocognitive functioning. As such, this report seeks to assess the extent of the correlation between affective temperament and cognitive function in a group of bipolar II subjects. 46 bipolar II outpatients [mean age 41.4 years (SD 18.2); female 58.9%] and 46 healthy controls [mean age 35.1 years (SD 18); female 56.5%] were evaluated with regard to their demographic and clinical characteristics, affective temperament, and neurocognitive performance. Crude bivariate correlation analyses and multiple linear regression models were constructed between five affective temperament subscales and eight neurocognitive domains. Significant correlations were identified in bipolar patients between hyperthymic temperament and verbal memory and premorbid IQ; cyclothymic temperament and attention; and irritable temperament, attention, and verbal fluency. In adjusting for potential confounders of the relationship between temperament and cognitive function, the strongest mediating factors among the euthymic bipolar patients were found to be residual manic and depressive symptoms. It is therefore concluded that affective temperaments may partially influence the neurocognitive performance of both healthy controls and euthymic patients with bipolar disorder type II in several specific domains.
Author affiliation: Romero, Ester. Universidad de Palermo; Argentina
Author affiliation: Holtzman, Jessica N.. Universidad de Palermo; Argentina. University of Stanford; Estados Unidos
Author affiliation: Tannenhaus, Lucila. Universidad de Palermo; Argentina
Author affiliation: Monchablon, Romina. Universidad de Palermo; Argentina
Author affiliation: Rago, Carlo Mario. Universidad de Palermo; Argentina. Instituto de Investigaciones Universitarias Roma la Sapienza; Italia
Author affiliation: Lolich, Maria. Universidad de Palermo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Author affiliation: Vázquez, Gustavo H.. Universidad de Palermo; Argentina. McLean Hospital; Estados Unidos
Keywords: Temperamental traits; Euthymia; Neurocognition; Affective disorder; Subsyndromal symptoms; Endophenotypes; Verbal memory; Visual memory; Planning; Set shifting; Attention; Working memory; Processing speed; Verbal fluency; Premorbid IQ; Salud Ocupacional; Ciencias de la Salud; CIENCIAS MÉDICAS Y DE LA SALUD.
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas