Authors: Nuñez, Julio; Rabinovich, Gabriel Adrian; Sandino, Justo; Mainar, Luis; Palau, Patricia; Santas, Enrique; Villanueva, María Pilar; Nuñez, Eduardo; Bodi, Vicent; Chorro, Francisco; Miñana, Gema; Sanchis, Juan
Publication Date: 2015.
AIM:Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have emerged as robust prognostic biomarkers in heart failure. Experimental data have also suggested a potential molecular interaction between CA125 and Gal-3; however, the biological and clinical relevance of this interaction is still uncertain. We sought to evaluate, in patients admitted for acute heart failure, the association between plasma Gal-3 with all-cause mortality and the risk for rehospitalizations among high and low levels of CA125. METHODS AND RESULTS: We included 264 consecutive patients admitted for acute heart failure to the Cardiology Department in a third-level center. Both biomarkers were measured on admission. Negative binomial and Cox regression models were used to evaluate the prognostic effect of the interaction between Gal-3 and CA125 (dichotomized by its median) with hospital readmission and all-cause mortality, respectively. During a median follow-up of 2 years (IQR = 1-2.8), 108 (40.9%) patients deaths and 365 rehospitalizations in 171 (69.5%) patients were registered. In a multivariable setting, the effect of Gal-3 on mortality and rehospitalization was differentially mediated by CA125 (p = 0.007 and p<0.001, respectively). Indeed, in patients with CA125 above median (>67 U/ml), values across the continuum of Gal-3 showed a positive and almost linear relationship with either the risk of death or rehospitalization. Conversely, when CA125 was below median (≤67 U/ml), Gal-3 lacked any prognostic effect on both endpoints. CONCLUSION: In patients with acute heart failure, Gal-3 was strongly associated with higher risk of long-term mortality and repeated rehospitalizations, but only in those patients exhibiting higher values of CA125.
Author affiliation: Nuñez, Julio. Universidad de Valencia; España
Author affiliation: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires; ; Argentina
Author affiliation: Sandino, Justo. Universidad de Valencia; España
Author affiliation: Mainar, Luis. Universidad de Valencia; España
Author affiliation: Palau, Patricia. Hospital de La Plana; España
Author affiliation: Santas, Enrique. Universidad de Valencia; España
Author affiliation: Villanueva, María Pilar.
Author affiliation: Nuñez, Eduardo. Universidad de Valencia; España
Author affiliation: Bodi, Vicent. Universidad de Valencia; España
Author affiliation: Chorro, Francisco. Universidad de Valencia; España
Author affiliation: Miñana, Gema. Hospital de Manises; España
Author affiliation: Sanchis, Juan. Universidad de Valencia; España
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas