Authors: Dirchwolf, Melisa; Marciano, Sebastián; Mauro, Ezequiel; Ruf, Andrés Eduardo; Rezzonico, Lucrecia; Anders, Margarita; Chiodi, Daniela; Gill Petta, Néstor; Borzi, Silvia; Tanno, Federico; Ridruejo, Ezequiel; Barreyro, Fernando Javier; Shulman, Carolina; Plaza, Pablo Maximiliano; Carbonetti, Rodolfo; Tadey, Luciana; Schroder, Teresa; Fainboim, Hugo
Publication Date: 2017.
Language: English.
Abstract:
There is scarce data pertaining to acute hepatitis C (aHC) infection in South America. We aimed to describe clinical characteristics and evolution of aHC in a South American cohort. A retrospective survey was conducted at 13 hepatology units. All patients ≥16 years old with aHC diagnosis were included. Demographic, clinical and outcome information were registered in a standardized ad hoc questionnaire. Sixty-four patients were included. The majority were middle-aged (median age: 46 years) and female (65.6%); most of them were symptomatic at diagnosis (79.6%). HCV-1 was the most prevalent genotype (69.2%). Five patients had liver failure: three cases of severe acute hepatitis, one case of fulminant hepatitis and one case of acute-on-chronic liver failure. Nosocomial exposure was the most prevalent risk factor. Evolution was assessed in 46 patients. In the untreated cohort, spontaneous resolution occurred in 45.8% and was associated with higher values of AST/ALT and with the absence of intermittent HCV RNA viremia (P = 0.01, 0.05, and 0.01, respectively). In the treated cohort, sustained virological response was associated with nosocomial transmission and early treatment initiation (P = 0.04 each). The prevalence of nosocomial transmission in this South-American cohort of aHC stresses the importance of following universal precautions to prevent HCV infection
Author affiliation: Dirchwolf, Melisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Author affiliation: Marciano, Sebastián. Hospital Italiano; Argentina
Author affiliation: Mauro, Ezequiel. Hospital Italiano; Argentina
Author affiliation: Ruf, Andrés Eduardo. Fundación para la Docencia e Investigación de las Enfermedades del Hígado; Argentina
Author affiliation: Rezzonico, Lucrecia. Hospital de la Asociación Médica “Dr. Felipe Glasman”; Argentina
Author affiliation: Anders, Margarita. Hospital Alemán; Argentina
Author affiliation: Chiodi, Daniela. Universidad de la República; Uruguay
Author affiliation: Gill Petta, Néstor. Hospital Central del Instituto de Previsión Social; Paraguay
Author affiliation: Borzi, Silvia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos Prof. Dr. Rodolfo Rossi; Argentina
Author affiliation: Tanno, Federico. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Author affiliation: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina
Author affiliation: Barreyro, Fernando Javier. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Author affiliation: Shulman, Carolina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos Dr. Enrique Tornú; Argentina
Author affiliation: Plaza, Pablo Maximiliano. Provincia de Salta. Ministerio de Salud Pública. Hospital Señor del Milagro; Argentina
Author affiliation: Carbonetti, Rodolfo. Provincia de Tucumán. Ministerio de Salud. Hospital de Clínicas Presidente Dr. Nicolás Avellaneda; Argentina
Author affiliation: Tadey, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Author affiliation: Schroder, Teresa. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Author affiliation: Fainboim, Hugo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas
Authors: Paladino, Natalia; Flores, Ana Claudia; Fainboim, Hugo; Schroder, Teresa; Cuarterolo, Miriam; Lezama, Carol; Gonzáles Ballerga, Esteban; Levi, Diana; Tanno, Hugo; Costanzo, Gabriel Gustavo; Arruvito, Maria Lourdes; Fainboim, Leonardo
Publication Date: 2010.
Language: English.
Abstract:
We previously reported that paediatric (PAH) and adult (AAH) forms of type I autoimmune hepatitis (AH) have different HLA-associations and clinical outcome. In the present study we investigated the role of TGF-β1 genetic polymorphisms in the different outcome of PAH and AAH. We found a significant increase of "high producer" 25GG genotype in PAH and 10CC in AAH. Low inflammation and low fibrosis in AAH was associated with the increase of codon 10CC (high producer) and codon 25CC (low producer) genotypes. The analysis in AAH of the two positions-haplotypes revealed that combined presence of 25GG and 10CC seems to neutralize the 10CC effect which remained in AAH having the 10CC+-25GG- haplotype. Altogether these results may explain, at least partially, the different clinical outcome of AAH and PAH.
Author affiliation: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Author affiliation: Flores, Ana Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Author affiliation: Fainboim, Hugo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Author affiliation: Schroder, Teresa. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Author affiliation: Cuarterolo, Miriam. Fundacion Hospital de Pediatria Professor Dr. Juan P. Garrahan; Argentina
Author affiliation: Lezama, Carol. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina
Author affiliation: Gonzáles Ballerga, Esteban. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Author affiliation: Levi, Diana. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina
Author affiliation: Tanno, Hugo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Author affiliation: Costanzo, Gabriel Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Author affiliation: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Author affiliation: Fainboim, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas