Publication Date: 2002.
Recent evidence has implicated galectins and their ligands as master regulators of immune cell homeostasis. Whereas some members of this family, such as galectin-3, behave as amplifiers of the inflammatory cascade, others, such as galectin-1, trigger homeostatic signals to shut off T-cell effector functions. These carbohydrate-binding proteins, identified by shared consensus amino acid sequences and affinity for beta-galactoside-containing sugars, participate in the homeostasis of the inflammatory response, either by regulating cell survival and signaling, influencing cell growth and chemotaxis, interfering with cytokine secretion, mediating cell-cell and cell-matrix interactions or influencing tumor progression and metastasis. The current wealth of new information promises a future scenario in which individual members of the galectin family or their ligands will be used as powerful anti-inflammatory mediators and selective modulators of the immune response.
Author affiliation: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Author affiliation: Baum, Linda Gwen. University of California at Los Angeles; Estados Unidos
Author affiliation: Tinari, N.. University ‘G. D; Italia
Author affiliation: Paganelli, Roberto. University ‘G. D; Italia
Author affiliation: Natoli, Clara. University ‘G. D; Italia
Author affiliation: Liu, Fu-tong. University of California at Davis; Estados Unidos
Author affiliation: Iacobelli, Stéfano. University ‘G. D; Italia
Repository: CONICET Digital (CONICET). Consejo Nacional de Investigaciones Científicas y Técnicas