Early diagnosis of congenital Trypanosoma cruzi infection, using shed acute phase antigen, in Ushuaia, Tierra del Fuego, Argentina

Authors
Mallimaci, María Cristina; Sosa-Estani, Sergio; Russomando, Graciela; Sanchez, Zunilda; Sijvarger, Carina; Alvarez, Isabel Marcela; Barrionuevo, Lola; Lopez, Carlos; Segura, Elsa L.
Publication Year
2010
Language
English
Format
article
Status
Published version
Description
Chagas’ disease, or American trypanosomiasis, is caused by the protozoan parasite Trypanasoma cruzi . It is estimated that 15,000 new cases of congenital T. cruzi transmission occur in the Americas each year. The aim of this study was to estimate the rate of congenital T. cruzi infection in infants born to infected women living in Ushuaia, Argentina, as well to assess a serologic test using Shed Acute Phase Antigen (SAPA) for a timely diagnosis of congenital infection. The rate of congenital infection among children in the study was 4.4% (3/68). Our results show that for infants younger than 30 days of age, matched blood samples from mother and infant were capable of identifying congenital transmission of infection using an enzyme-linked immunosorbent assay with SAPA. For infants older than 3 months, congenital infection could be ruled out using the same procedure.
Fil: Mallimaci, María Cristina. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina.
Fil: Russomando, Graciela. Universidad Nacional de Asunción. Departamento de Biología Molecular y Genética; Paraguay.
Fil: Sanchez, Zunilda. Universidad Nacional de Asunción. Departamento de Biología Molecular y Genética; Paraguay.
Fil: Sijvarger, Carina. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Alvarez, Isabel Marcela. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Barrionuevo, Lola. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Lopez, Carlos. Hospital Regional Ushuaia. Laboratorio Central; Argentina.
Fil: Segura, Elsa, Leonor. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
Source
The American Journal of Tropical Medicine and Hygiene, 2010, 82(1), 55–59.
Subject
Trypanosoma cruzi
Enfermedad de Chagas
Recién Nacido
Complicaciones Parasitarias del Embarazo
Argentina
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repository
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institution
Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos Malbrán”
OAI Identifier
oai:repositorio.anlis.gov.ar:123456789/238