Human papillomavirus cervical infection in Guarani Indians from the rainforest of Misiones, Argentina

Authors
Tonon, Sergio Andrés; Picconi, María Alejandra; Zinovich, Jorge Bruno; Nardari, Wanda; Mampaey, Mariana; Badano, Inés; di Lello, Federico; Galuppo, Juan Antonio; Alonio, Lidia V.; Teyssie, Angelica R.
Publication Year
2004
Language
English
Format
article
Status
Published version
Description
To evaluate the prevalence of human papillomavirus (HPV) cervical infection in women from the South American Guarani Indian tribe located in the rain forest of Misiones, north-eastern Argentina; a region with a high incidence of cervical carcinoma. Methods: A cross-sectional cytological and HPV screening of sexually active Guarani women from nine Indian settlements was conducted. Demographic data, information about sexual behavior, and gynaecological history were recorded. Fresh cervical specimens from 239 patients were collected, of which 207 were included in this study. Cytology and microbiological detection were carried out by the Papanicolaou and Gram stain methods, respectively. HPV detection and typing were analyzed by PCR and RFLP. Results: Pap smears in 96% of all patients showed an inflammatory pattern. A possible etiologic agent was found in 58% of cases: 52% Trichomonas vaginalis, 35% Gardnerella vaginalis and 13% Candida sp. Seven cases had cytological changes compatible with Low Grade Intraepithelial Lesion (LGSIL), one with High Grade Intraepithelial Lesion (HGSIL) and one in situ cervical cancer. The prevalence for generic HPV infection was 64% (133/207). Genotyping gave a 26% prevalence for HPV types 16/18, 13% for types 6/11 and 30% for other types, with nine mixed infections. Conclusion: This work reports for the first time the prevalence of cervical HPV infection in Guarani women. Nearly all Guarani women had some grade of cervical disease. Generic HPV infection prevalence was elevated (64%), with predominance of high risk types 16/18. A large variety of viral types was detected, including high to intermediate risk types not found previously in the region.
Fil: Tonon, Sergio Andrés. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Zinovich, Jorge Bruno. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: Nardari, Wanda. Ministerio de Salud Pública de la Provincia de Misiones; Argentina.
Fil: Mampaey, Mariana. Ministerio de Salud Pública de la Provincia de Misiones; Argentina.
Fil: Badano, Inés. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: di Lello, Federico. Universidad Nacional de Misiones. Laboratorio de Biología Molecular Aplicada; Argentina.
Fil: Galuppo, Juan Antonio. Universidad Nacional de Misiones. Cátedra de Citología e Histología; Argentina.
Fil: Alonio, Lidia Virginia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Teyssie, Angélica Rita. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Source
International Journal of Infectious Diseases, 2004, 8(1), 13-19.
Subject
Infecciones por Papillomavirus
Neoplasias del Cuello Uterino
Enfermedades de Transmisión Sexual
Argentina
Misiones
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repository
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institution
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identifier
oai:repositorio.anlis.gov.ar:123456789/423