Antimicrobial and anti-inflammatory screening of four indian medicinal plants

Authors
Vaghasiya, Yogeshkumar K.; Parekh, Jigna P.; Shukla, Vinay J.; Chanda, Sumitra V.
Publication Year
2011
Language
English
Format
article
Status
Published version
Description
Inflammatory diseases including different types of rheumatic diseases are very common throughout the world. The greatest disadvantage in the presently available potent synthetic drugs lies in their side effects, toxicity and reappearance of the symptoms after discontinuation. Hence search for new antimicrobial and anti-inflammatory agents are needed. Antimicrobial study was done by agar disc diffusion method against 5 Gram positive, 7 Gram negative and 3 fungal strains and acute anti-inflammatory activity was studied by carrageenan induced paw edema in rats. Plants screened were Aristolochia indica, Argemone mexicana, Alpinia speciosa and Gymnema sylvestre. Methanolic extract of these plants were studied at 200 mg/kg and 400 mg/kg dose level. The results were compared with standard drug indomethacin. All the plant extracts showed better antibacterial activity than antifungal activity. The Gram positive bacteria were more susceptible than Gram negative bacteria. Argemone mexicana gave more antimicrobial and anti-inflammatory activity than the other three plants.
Colegio de Farmacéuticos de la Provincia de Buenos Aires
Subject
Farmacia
Plantas Medicinales
Enfermedades Reumáticas
Agentes Antibacterianos
antimicrobial; anti-inflammatory; agar disc diffusion; carrageenan; Aristolochia indica; Argemone mexicana; Alpinia speciosa; Gymnema sylvestre
Access level
Open access
License
Licencia de distribución no exclusiva SEDICI
Repository
SEDICI (UNLP)
Institution
Universidad Nacional de La Plata
OAI Identifier
oai:sedici.unlp.edu.ar:10915/8198