Indomethacin solubility in propylene glycol + water mixtures according to the extended hildebrand solubility approach

Authors
Holguín, Andrés R.; Delgado, Daniel R.; Martínez, Fleming
Publication Year
2012
Language
English
Format
article
Status
Published version
Description
In this work the Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of the analgesic drug indomethacin in propylene glycol + water mixtures at 298.15 K. An acceptable correlative capacity of EHSA was found using a regular polynomial model in order four (overall deviation lower than 2.2 %), when the W interaction parameter is related to the solubility parameter of the mixtures. Nevertheless, the deviations obtained in the estimated solubility with respect to experimental solubility were similar to those obtained directly by means of an empiric regression of the experimental solubility as a function of the mixtures’ solubility parameters.
Colegio de Farmacéuticos de la Provincia de Buenos Aires
Subject
Farmacia
Indometacina
Solubilidad
Glicoles de Propileno
Agua
Binary mixtures
Extended Hildebrand solubility approach
Indomethacin
Solubility parameter
Access level
Open access
License
Licencia de distribución no exclusiva SEDICI
Repository
SEDICI (UNLP)
Institution
Universidad Nacional de La Plata
OAI Identifier
oai:sedici.unlp.edu.ar:10915/20224