South American medicinal flora: a promising source of novel compounds with antiprotozoal activity

Authors
Frank, Fernanda M.; Sülsen, Valeria P.; Cazorla, Silvia I.; Anesini, Claudia; Muschietti, Liliana V.; Martino, Virginia S.
Publication Year
2011
Language
English
Format
review
Status
Published version
Description
Native populations of South America have employed herb-based preparations for the treatment of parasite diseases. In this review, some examples of South American medicinal plants from which bioactive molecules have been isolated are presented. Results of our research related to the study of novel compounds with antiprotozoal activity are also presented herein. Peruvin and psilostachyin, two sesquiterpene lactones isolated from the Argentine medicinal species Ambrosia tenuifolia, presented significative in vitro activity on Trypanosoma cruzi epimastigotes and trypomastigotes. Psilostachyin also presented in vivo activity in T. cruzi infected mice. Both compounds were also active on Leishmania spp. The results obtained suggest that psilostachyin could be considered a potential lead molecule in the development of novel trypanocidal agents.
Colegio de Farmacéuticos de la Provincia de Buenos Aires
Subject
Farmacia
Agentes Antiprotozoarios
Plantas Medicinales
antiprotozoal activity; sesquiterpene lactones; South American medicinal species
Access level
Open access
License
Licencia de distribución no exclusiva SEDICI
Repository
SEDICI (UNLP)
Institution
Universidad Nacional de La Plata
OAI Identifier
oai:sedici.unlp.edu.ar:10915/8125