Generation and characterization of novel magnetic field-responsive biomaterials.

Authors
López López, M.T.; Scionti, G.; Oliveira, A.C.; G. Durán, J.D.; Campos, A.; Alaminos, M.; Rodríguez, I.A.
Publication Year
2015
Language
English
Format
article
Status
Published version
Description
We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin–agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces.This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications.
publishedVersion
Subject
Biocompatible materials
Family characteristics
Characterization
Access level
Open access
License
Repository
Repositorio Digital Universitario (UNC)
Institution
Universidad Nacional de Córdoba
OAI Identifier
oai:rdu.unc.edu.ar:11086/4931