Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in nonaborting chronically infected cattle un...

Authors
Pereyra, Walter Rodrigo; Mansilla, Florencia Celeste; Petersen, Marcos Ivan; Suarez, Victor Humberto; Capozzo, Alejandra Victoria
Publication Year
2019
Language
Spanish
Format
article
Status
Published version
Description
Neospora caninum infection of cattle can be vertically transmitted, resulting in abortion or birth of infected calves. Vertical transmission occurs both in acutely or chronically infected cattle. There is little information on the immune response needed to prevent endogenous transplacental transmission, particularly from chronically infected cattle to their offspring in a natural environment. In this study, N. caninum seropositive pregnant cattle from three different farms with high avidity antibodies and low IgM titers were selected and their newborn colostrum-deprived calves were tested for anti-N. caninum antibodies. Based on these results, dams were grouped according to their congenital transmission status. The analysis of the immune profile of the chronically-infected pregnant cattle revealed that higher ratio between IgG1 and IgG2 anti-N. caninum serum titers and higher levels of systemic IFN-γ were associated with diminished vertical transmission rates, compared to dams with the opposite profile. Our results evidenced an association between the immune profile and vertical transmission in nonaborting chronically infected dams, and confirm that vertical transmission, even when not leading to abortion, is related to a defined immune profile. This is important information to accomplish successful vaccine development efforts.
EEA Salta
Fil: Pereyra, Walter Rodrigo. INTA. Instituto de Investigación Animal Chaco Semiarido. Grupo de Patología, Epidemiología e Investigación Diagnóstica-Área de Sanidad Animal; Argentinaía General y Especial; Argentina
Fil: Mansilla, Florencia Celeste. INTA. Instituto de Virología; Argentina
Fil: Petersen, Marcos Ivan. INTA. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Fil: Suarez, Victor Humberto. INTA. Instituto de Investigación Animal Chaco Semiarido. Grupo de Patología, Epidemiología e Investigación Diagnóstica-Área de Sanidad Animal; Argentinaía General y Especial; Argentina
Fil: Capozzo, Alejandra Victoria. INTA. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina
Source
Veterinary immunology and immunopathology 208 : 53-57. (February 2019)
Subject
Neospora Caninum
Infección
Respuesta Inmunológica
Bovina
Transmisión de Enfermedades
Infection
Immune Response
Bovinae
Vertical Transmission
Disease Transmission
Transplacental Transmission
Chronic Infection
IgG Subtypes
Access level
Restricted access
License
Repository
INTA Digital (INTA)
Institution
Instituto Nacional de Tecnología Agropecuaria
OAI Identifier
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