Differences in the virulence of two strains of Foot-and-Mouth Disease Virus Serotype A with the same spatiotemporal distribution

Authors
Garcia Nuñez, Maria Soledad; Konig, Guido Alberto; Berinstein, Analia; Carrillo, Elisa Cristina
Publication Year
2010
Language
English
Format
article
Status
Published version
Description
During the 2000–2001 epidemic of Foot-and-Mouth Disease Virus (FMDV) in Argentina, two FMDV serotype A viruses were identified among others. Since different pathogenic properties between these virus strains were noticed in cattle, we evaluated several biological properties and features of FMDV A/Arg/00 and FMDV A/Arg/01 in order to compare these viruses in terms of virulence and pathogenicity. Our results indicate that FMDV A/Arg/00 grows less efficiently than FMDV A/Arg/01, exemplified by smaller sized plaques, retarded one-step growth curves and overall low viral yields. Also, FMDV A/Arg/00 displayed the lowest specific infectivity in suckling mice requiring 50-fold more infectious particles than FMDV A/Arg/01 to generate a LD50 in suckling mice. Finally, FMDV A/Arg/00 did not cause death in adult C57Bl/6 mice even at high doses (107–106 PFU) whereas FMDV A/Arg/01 resulted lethal in doses as low as 102 PFU. Overall, we were able to demonstrate that these virus strains differ from each other in terms of virulence and pathogenicity.
Instituto de Biotecnología
Fil: Garcia Nuñez, Maria Soledad. INTA. Instituto de Biotecnología; Argentina
Fil: Konig, Guido Alberto. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Berinstein, Analia. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carrillo, Elisa Cristina. INTA. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Source
Virus Research 147 (1) : 149-152 (January 2010)
Subject
Enfermedades de los Animales
Virus Fiebre Aftosa
Fiebre Aftosa
Serotipos
Virulencia
Animal Diseases
Aphthovirus
Foot and Mouth Disease
Serotypes
Virulence
Access level
Restricted access
License
Repository
INTA Digital (INTA)
Institution
Instituto Nacional de Tecnología Agropecuaria
OAI Identifier
oai:localhost:20.500.12123/5311