Virulence factors of the Mycobacterium tuberculosis complex

Authors
Forrellad, Marina Andrea; Klepp, Laura Ines; Gioffre, Andrea; Sabio y Garcia, Julia Veronica; Morbidoni, Hector R.; Santangelo, María De La Paz; Cataldi, Angel Adrian; Bigi, Fabiana
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world.
Instituto de Biotecnología
Fil: Forrellad, Marina Andrea. INTA. Instituto de Biotecnología; Argentina
Fil: Klepp, Laura Ines. INTA. Instituto de Biotecnología; Argentina
Fil: Gioffre, Andrea. INTA. Instituto de Biotecnología; Argentina
Fil: Sabio y Garcia, Julia Veronica. INTA. Instituto de Biotecnología; Argentina
Fil: Morbidoni, Hector R. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Cátedra de Microbiología; Argentina
Fil: Santangelo, María De La Paz. INTA. Instituto de Biotecnología; Argentina.
Fil: Cataldi, Angel Adrian. INTA. Instituto de Biotecnología; Argentina
Fil: Bigi, Fabiana. INTA. Instituto de Biotecnología; Argentina
Source
Virulence 4 (1) : 3-66 (2013)
Subject
Mycobacterium tuberculosis
Virulencia
Patogenicidad
Control de Enfermedades
Vacuna
Virulence
Pathogenicity
Disease Control
Vaccines
Access level
Open access
License
Repository
INTA Digital (INTA)
Institution
Instituto Nacional de Tecnología Agropecuaria
OAI Identifier
oai:localhost:20.500.12123/4293