Characterization of Immune Cell Infiltration in the Placentome of Water Buffaloes (Bubalus bubalis) Infected with Neospora caninum During Pregnancy

Authors
Canton, German Jose; Konrad, Jose Luis; Moore, Prando Dadin; Caspe, Sergio Gaston; Palarea-Albaladejo, Javier; Campero, Carlos Manuel; Chianini, Francesca
Publication Year
2014
Language
English
Format
article
Status
Versión aceptada para publicación
Description
Neospora caninum infection in cattle stimulates host immune responses, which may be responsible for placental damage leading to abortion. Susceptibility of water buffaloes (Bubalus bubalis) to neosporosis is not well understood, although vertical transmission and fetal death have been documented. The aim of this study was to characterize the immune response in the placentome of water buffalo following experimental infection in early gestation with the Nc-1 strain of N. caninum. Placentomes were examined by immunohistochemistry using antibodies specific for T-cell subsets, natural killer cells and CD79αcy cells. Placental inflammation was characterized by the infiltration of CD3+ and CD4+ T cells and T cells expressing the γδ T-cell receptor. The distribution of these cellular subsets in buffalo placentomes was similar to that previously described in cattle infected with N. caninum in early gestation, but the lesions were milder, which may explain the lower number of abortions observed in this species after infection.
EEA Balcarce
Fil: Canton, German Jose. Moredun Research Institute; Reino Unido. INTA. Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Konrad, Jose Luis. Universidad Nacional del Nordeste. Facultad de Veterinaria; Argentina
Fil: Moore, Prando Dadin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Caspe, Sergio Gaston. INTA. Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Palarea-Albaladejo, Javier. Biomathematics & Statistics Scotland; Reino Unido
Fil: Campero, Carlos Manuel. INTA. Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Chianini, Francesca. Moredun Research Institute; Reino Unido
Source
Journal of Comparative Pathology 150 (4) : 463-468 (May 2014)
Subject
Neospora caninum
Respuesta Inmunológica
Búfalo de Agua
Gestación
Inmunidad
Immune Response
Water Buffaloes
Pregnancy
Immunity
Access level
Open access
License
Repository
INTA Digital (INTA)
Institution
Instituto Nacional de Tecnología Agropecuaria
OAI Identifier
oai:localhost:20.500.12123/4559