Effect of GnRH analogs in postnatal domestic cats

Authors
Carranza Martin, Ana Cristina; Faya, Marcela Inés; López Merlo, Mariana Lucía; Batista, Pablo Rodrigo; Gobello, María Cristina
Publication Year
2014
Language
English
Format
article
Status
Published version
Description
The aim of this study was to reproductively assess the clinical and hormonal effects of a GnRH agonist (AG) and an antagonist (AN) administered during the postnatal period in domestic cats. Forty-eight male and female postnatal kittens were randomly assigned to deslorelin acetate 1.6 mg subcutaneous (AG; n¼16), acyline 33mg/100 g subcutaneous weekly for 3 months (AN; n¼16), or control (CO; n¼16) which remained untreated. The cats were followed up (behavioral observation, physical examination, fecal sexual steroid determinations, mating test, and pregnancy diagnosis) up to puberty. Puberty was delayed (weeks) in the AG animals (62.93.5; P<0.01) but not in the AN (15.51.7; P>0.05)when they were compared with CO kittens (13.40.4). Fifteen (15/16) of the AN and CO animals, and only 11 of 16 cats of the AG group were fertile (P>0.1). No differences were found in body weight (P >0.1) and measurements (P>0.1), libido (P>0.1) and in the appearance of side effects (P>0.1; except a pyometra in an AG female) among groups. In both AG- and AN-treated males (testosterone; P<0.01) and females (estradiol-17b;P<0.01) fecal hormone concentrations were lower than in CO group during thefirstfive postnatal weeks but not later. It is concluded that the neonatal administration of these AG and AN decreased fecal sexual steroids during thefirst postnatal weeks causing, the agonists but not the antagonist, a significant, reversible delay in puberty appearance.
Fil: Carranza Martin, Ana Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Faya, Marcela Inés. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Universidad Católica de Córdoba; Argentina
Fil: López Merlo, Mariana Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Batista, Pablo Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Gobello, María Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Subject
FELINE
GnRH AGONIST
GnRH ANTAGONIST
NEONATE
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/32576