Antiviral activity of lambda-carrageenan prepared from red seaweed (Gigartina skottsbergii) against BoHV-1 and SuHV-1

Authors
Diogo, Jésica Victoria; Galdo Novo, Sabrina; Gonzalez, Marcelo Jose; Ciancia, Marina; Bratanich, Ana Cristina
Publication Year
2015
Language
English
Format
article
Status
Published version
Description
The antiviral effect of polysaccharides has been known for many years. Carrageenans are considered a good alternative for the prevention of a wide range of diseases, mainly caused by enveloped viruses. The advantages lie on their high availability, low cost and low induction of resistance. The aim of this study was to evaluate the sensitivity of two viral pathogens of veterinary interest to the presence of lambda-carrageenan. This is the first report of a lambda-carrageenan having antiviral activity against animal viruses belonging to the Alphaherpesvirinae subfamily, BoHV-1 (bovine herpesvirus type 1) strain Cooper and SuHV-1 (suid herpesvirus type 1) strain Bartha. Lambda-carrageenan was able to reduce infectivity of both viruses with a more pronounced effect against BoHV-1. These results proved, as previously shown for human herpes virus type 1, that these compounds could be used as potential antiviral agents in the veterinary field.
Fil: Diogo, Jésica Victoria. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Galdo Novo, Sabrina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; Argentina
Fil: Gonzalez, Marcelo Jose. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; Argentina
Fil: Ciancia, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentina
Fil: Bratanich, Ana Cristina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; Argentina
Subject
LAMBDA CARRAGEENAN
BOVINE HERPES VIRUS TYPE 1
SUID HERPES VIRUS TYPE 1
ANTIVIRAL ACTIVITY
Virología
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/17773