Galectin-1 serum levels reflect tumor burden and adverse clinical features in classical Hodgkin lymphoma

Authors
Ouyang, Jing; Plütschow, Annette; Von Strandmann, Elke Pogge; Reiners, Katrin S.; Ponader, Sabine; Rabinovich, Gabriel Adrian; Neuberg, Donna; Engert, Andreas; Shipp, Margaret A.
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
Galectin-1 (Gal1) is a member of a highly conserved family of carbohydrate-binding proteins that modulates innate and adaptive immune responses and fosters tumor-immune escape. Hodgkin lymphoma (HL) Reed-Sternberg (RS) cells overexpress and secrete Gal1, which selectively kills Th1,Th17 and cytotoxic T cells and promotes the immunosuppressive Th2/Treg-predominant HL microenvironment. We developed a sandwich ELISA and assessed serum Gal1 levels in 315 newly diagnosed, previously untreated HL patients enrolled on 3 risk-adapted clinical trials. Serum Gal1 levels were significantly higher in HL patients than in normal controls (p < .0001). Gal1 serum levels also increased with Ann Arbor stage (p < .0001), areas of nodal involvement (p = .0001) and the International Prognostic Score (IPS) (2-7, p = .006). We conclude that Gal1 serum levels are significantly associated with tumor burden and additional adverse clinical characteristics in newly diagnosed HL Patients.
Fil: Ouyang, Jing. Dana-Farber Cancer Institute. Department of Medical Oncology; Estados Unidos de América;
Fil: Plütschow, Annette. German Hodgkin Study Group; Alemania;
Fil: Von Strandmann, Elke Pogge. University Hospital of Cologne. Laboratory for Immunotherapy; Alemania;
Fil: Reiners, Katrin S.. University Hospital of Cologne. Laboratory for Immunotherapy; Alemania;
Fil: Ponader, Sabine. German Hodgkin Study Group; Alemania;
Fil: Rabinovich, Gabriel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina;
Fil: Neuberg, Donna. Dana-Farber Cancer Institute. Department of Biostatistics; Estados Unidos de América;
Fil: Engert, Andreas. German Hodgkin Study Group; Alemania;
Fil: Shipp, Margaret A.. Dana-Farber Cancer Institute. Department of Medical Oncology; Estados Unidos de América;
Subject
GALECTIN-1
HODGKIN DISEASE
PROGNOSIS
ELISA
CASE CONTROL-STUDIES
NEOPLASM STAGING
Patología
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Oncología
Medicina Clínica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/2358