Age-of-onset of menopause is associated with enhanced painful and non-painful sensitivity in fibromyalgia

Authors
Martinez Jauand, Mercedes; Sitges Quirós, Carol; Femenia, Joan Reines; Cifre, Ignacio; Gonzalez, Susana Laura; Chialvo, Dante Renato; Montoya Jimenez, Pedro José
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
Fibromyalgia (FM) is a chronic pain condition characterized by high prevalence in women. In particular, estrogen deficit has been considered as a potentially promoting factor of FM symptoms. This study was aimed to examine the relationship between age-of-onset of menopause and pain sensitivity in FM. For this purpose, pain sensitivity was assessed in 74 FM and 32 pain-free control women. All participants were postmenopausal and underwent a detailed semi-structured clinical interview, including data about menopause transition, previous history of hysterectomy or ovariectomy, and menses time. Participants were divided into two groups depending on age-of-onset of menopause: early menopause [≤49 years] vs. late menopause [>49 years]. Pain and non-pain thresholds were assessed by using cold, heat, mechanical, and electrical stimulation. FM women showed higher overall pain sensitivity as compared with healthy subjects. FM women with early age-of-onset of menopause displayed greater pain and non-pain sensitivity than FM women with late age-of-onset of menopause, whereas no differences were observed in healthy women due to age-of-onset of menopause. These results suggest that an early transition to menopause (shortening the time of exposure to estrogens) may influence pain hypersensitivity and could be related to aggravation of FM symptoms.
Fil: Martinez Jauand, Mercedes. Universidad de las Islas Baleares. Instituto Universitario de Investigación en Ciencias de la Salud. ; España
Fil: Sitges Quirós, Carol. Universidad de las Islas Baleares. Instituto Universitario de Investigación en Ciencias de la Salud; España. Universidad de las Islas Baleares; España
Fil: Femenia, Joan Reines. Universidad de las Islas Baleares. Instituto Universitario de Investigación en Ciencias de la Salud; España
Fil: Cifre, Ignacio. Universidad de las Islas Baleares. Instituto Universitario de Investigación en Ciencias de la Salud; España
Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Chialvo, Dante Renato. Universidad de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Montoya Jimenez, Pedro José. Universidad de las Islas Baleares. Instituto Universitario de Investigación en Ciencias de la Salud; España
Subject
FIBROMYALGIA
MENOPAUSE
NON-PAIN THRESHOLDS
ESTROGEN
PAIN THRESHOLDS
Neurociencias
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/2621