Effects of antidepressants and soybean association in depressive menopausal women

Authors
Nina Estrella, Rose Emily; Landa de Gargiulo, Adriana; Lafuente, José Vicente; Gargiulo, Pascual Angel
Publication Year
2014
Language
English
Format
article
Status
Published version
Description
Depression in menopausal women has been widely described for many years ago, and is related to hormonal decrease, mainly estrogens. The use of soy has been proposed as a possible coadjutant alternative to treat menopausal depressive disorder. In the present pilot clinical trial the effect of soybean, antidepressants and the association of soybean with antidepressants was studied in 40 depressive menopausal women for three months. Patients were divided in four groups of 10 women: fluoxetine (10 mg), soybean (100 mg), sertraline (50 mg), and sertraline (50 mg) plus soybean (100 mg). The Hamilton and Zung Depression Scales were used to measure the treatment effects. Values at the beginning and at the end of the study were compared. In all cases a significant difference was observed when the treated groups were compared vs. their untreated situation in both scales (p < 0.001). When a comparison between pre- minus post-treatment Zung scale scores was done,the effect induced by the association of sertraline and soybean was significantly higher than the other groups (p < 0.05). These effects were also seen using the Hamilton scale scores, showing significant differences between the association vs. soybean (p < 0.05) and setraline (p < 0.05) groups, but not vs. fluoxetine group. We conclude that soybean has an antidepressant effect per se, and the association of soybean and antidepressants increases their effects.
Fil: Nina Estrella, Rose Emily. Universidad Autónoma de Santo Domingo. Faculty of Health Science. School of Physiological Sciences; República Dominicana
Fil: Landa de Gargiulo, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Lafuente, José Vicente. Universidad del Pais Vasco. Departamento de Neurociencia. Laboratorio de Neurociencia Experimental; España. Universidad Autónoma de Chile. Facultad de Ciencias de la Salud; Chile
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Subject
Menopause
Depressive disorder
Soybean
Antidepressant
Serotonin Selective Reuptake inhibitor
Reumatología
Medicina Clínica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/27284