Spray-Dried Cascara sagrada Extract for Direct Compression: Tablet Formulation and a Simple HPLC Method for Tablet Performance Evaluation

Authors
Gallo, Loreana Carolina; Ramírez Rigo, María Veronica; Wilson, Érica; Piña, Juliana; Allemandi, Daniel Alberto; Bucala, Veronica
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
Cascara sagrada bark is extensively used in the treatment of occasional constipation. Despite its wide diffusion, Cascara sagrada dried extracts with good flow and compactability properties for tablet formulation by direct compression and simple methods for the determination of Cascara sagrada extract release from tablets are not available. To overcome this lack of information, this article is focused on the design of tablets based on a Cascara sagrada extract obtained by spray-drying and on the quantification of its active constituents using a novel and isocratic HPLC-UV technique, which was validated. Flow properties of the Cascara sagrada spraydried extract and of the physical mixtures of it with conventional excipients were evaluated. The different formulated powders were compacted and their properties (i.e., hardness, friability, disintegration and dissolution) were studied. The proposed tablet formulations, based on the Cascara sagrada spray-dried extract, reached the pharmacopoeial requirements for immediate release tablets. In particular, the formulas containing a superdisintegrant showed the best pharmaceutical performance. Nevertheless, the use of excipients to improve the powder flow and/or the tablets properties was not strictly necessary. Besides, the HPLC-UV method used to monitor the extract release from tablets was validated, proving to be linear within the concentration range adequate for therapeutic purposes and appropriate for routine analysis due to its simplicity, good sensitivity, accuracy and precision.
Fil: Gallo, Loreana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Wilson, Érica . Universidad de Belgrano; Argentina
Fil: Piña, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Unidad de Investigacion y Desarrollo en Tecnologia Farmaceutica; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur. Departamento de Ingenieria Quimica; Argentina
Subject
Spray drying
Cascara sagrada bark
Tablets
direct compression
HPLC method
Otras Ciencias de la Salud
Ciencias de la Salud
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/12018