A new calcium releasing nano-composite biomaterial for bone tissue engineering scaffolds

Authors
Cattalini, Juan Pablo; Garcia, J,; Boccaccini, A. R.; Lucangioli, Silvia Edith; Mouriño, Viviana Silvia Lourdes
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
A biomaterial with bioactive glass nanoparticles (nBG) and Ca2+ incorporated into alginate matrix was developed. Films characterization was carried out by SEM, IR, tensile strength measurements, bioactivity assay, degradation and swelling studies. Ca2+ release from films was analyzed. Freeze-dried-scaffolds were also fabricated. Films showed the development of a homogeneous matrix and the mechanical properties were improved when nBG were incorporated. The bioactive nature of nBG containing films was confirmed by studies in simulated body fluid. Degradation was negligible and a good swelling capacity was observed. Moreover Ca2+ was released in a controlled manner. In scaffolds fabricated by freeze-drying, pores were seen to be uniform and well distributed. According to the characterization results, these composite biomaterials are attractive candidates for the fabrication of bone tissue engineering scaffolds.
Fil: Cattalini, Juan Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina;
Fil: Garcia, J,. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina;
Fil: Boccaccini, A. R.. Universitat Erlangen-Nuremberg; Alemania;
Fil: Lucangioli, Silvia Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
Fil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
Subject
COMPOSITES
BIOMATERIALS
FILMS
CALCIUM
Nano-materiales
Nanotecnología
INGENIERÍAS Y TECNOLOGÍAS
Bioproductos, Biomateriales, Bioplásticos, Biocombustibles, Bioderivados, etc.
Biotecnología Industrial
INGENIERÍAS Y TECNOLOGÍAS
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/1927