Nanoscale Kolliphor® HS 15 micelles to minimize rifampicin self-aggregation in aqueous media

Authors
Grotz, Estefanía; Bernabeu, Ezequiel Adrian; Pappalardo, Monica; Chiappetta, Diego Andrés; Moretton, Marcela Analía
Publication Year
2017
Language
English
Format
article
Status
Published version
Description
Tuberculosis is a highly-deadly disease that affects both children and adults. Rifampicin, one of the “first-line” anti tuberculosis drugs, self-aggregates in aqueous solutions where the critical aggregation concentration demonstrated a temperature-dependent behavior. Interestingly, drug self-aggregation could negatively affect the development of liquid aqueous rifampicin pediatric tuberculosis formulations. Therefore, our nanotechnological strategy to minimize this effect was the rifampicin encapsulation within polymeric micelles, employing the commercially available Kolliphor® HS 15, as the micelle-former biomaterial. The results show that Kolliphor® HS 15 is able to prevent rifampicin aqueous self-aggregation and precipitation, when used at certain concentrations. In this context, our work opens the possibility of developing aqueous liquid rifampicin dosage forms for pediatric patients to improve tuberculosis treatment.
Fil: Grotz, Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Bernabeu, Ezequiel Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Pappalardo, Monica. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Moretton, Marcela Analía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Subject
KOLLIPHOR® HS 15
LIQUID PEDIATRIC FORMULATIONS
PHYSICAL STABILITY
POLYMERIC MICELLES
RIFAMPICIN
SELF-AGGREGATION
Nano-materiales
Nanotecnología
INGENIERÍAS Y TECNOLOGÍAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/66744