Convergence of interoception, emotion, and social cognition: A twofold fMRI meta-analysis and lesion approach

Authors
Gonzalez Adolfi, Federico; Couto, Juan Blas Marcos; Richter, Fabian; Decety, Jean; Lopez, Jessica; Sigman, Mariano; Manes, Facundo Francisco; Ibáñez Barassi, Agustín Mariano
Publication Year
2017
Language
English
Format
article
Status
Published version
Description
Guided by indirect evidence, recent approaches propose a tripartite crosstalk among interoceptive signaling, emotional regulation, and low-level social cognition. Here we examined the neurocognitive convergence of such domains. First, we performed three meta-analyses of functional magnetic resonance imaging studies to identify which areas are consistently coactivated by these three systems. Multi-level Kernel Density Analysis (MKDA) revealed major overlaps in the right anterior insular and frontotemporal regions (viz., the orbitofrontal and inferior frontal gyri, the amygdala, and mid temporal lobe/subcortical structures). Second, we explored such domains in patients with fronto-insulo-temporal damage. Relative to controls, the patients showed behavioral impairments of interoception, emotional processing, and social cognition, with preservation of other cognitive functions. Convergent results from both studies offer direct support for a model of insular-frontotemporal regions integrating interoception, emotion, and social cognition.
Fil: Gonzalez Adolfi, Federico. Instituto de Neurología Cognitiva; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Artes y Ciencias Musicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Couto, Juan Blas Marcos. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Richter, Fabian. Universitat zu Köln; Alemania
Fil: Decety, Jean. University of Chicago; Estados Unidos
Fil: Lopez, Jessica. Universidad Santiago de Cali; Colombia
Fil: Sigman, Mariano. Universidad Torcuato Di Tella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manes, Facundo Francisco. Instituto de Neurología Cognitiva; Argentina. Australian Research Council. Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ibáñez Barassi, Agustín Mariano. Instituto de Neurología Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Australian Research Council. Centre of Excellence in Cognition and its Disorders; Australia. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Subject
FRONTOTEMPORAL NETWORKS
INSULA
MULTI-LEVEL KERNEL DENSITY ANALYSIS
STROKE
Neurociencias
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/72876