Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic

Authors
Levecke, Bruno; Montresor, Antonio; Albonico, Marco; Ame, Shaali M.; Behnke, Jerzy M.; Bethony, Jeffrey M.; Noumedem, Calvine D.; Engels, Dirk; Guillard, Bertrand; Kotze, Andrew; Krolewiecki, Alejandro Javier; McCarthy, James; Mekonnen, Zeleke; Periago, Maria V.; Sopheak, Hem; Tchuem Tchuente, Louis Albert; Duong, Tran Thanh; Huong, Nguyen Thu; Zeynudin, Ahmed; Vercruysse, Jozef
Publication Year
2014
Language
English
Format
article
Status
Published version
Description
Background: Robust reference values for fecal egg count reduction (FECR) rates of the most widely used anthelmintic drugsin preventive chemotherapy (PC) programs for controlling soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuristrichiura, and hookworm) are still lacking. However, they are urgently needed to ensure detection of reduced efficacies thatare predicted to occur due to growing drug pressure. Here, using a standardized methodology, we assessed the FECR rateof a single oral dose of mebendazole (MEB; 500 mg) against STHs in six trials in school children in different locations aroundthe world. Our results are compared with those previously obtained for similarly conducted trials of a single oral dose ofalbendazole (ALB; 400 mg).Methodology: The efficacy of MEB, as assessed by FECR, was determined in six trials involving 5,830 school children in Brazil,Cambodia, Cameroon, Ethiopia, United Republic of Tanzania, and Vietnam. The efficacy of MEB was compared to that of ALBas previously assessed in 8,841 school children in India and all the above-mentioned study sites, using identicalmethodologies.Principal Findings: The estimated FECR rate [95% confidence interval] of MEB was highest for A. lumbricoides (97.6% [95.8;99.5]), followed by hookworm (79.6% [71.0; 88.3]). For T. trichiura, the estimated FECR rate was 63.1% [51.6; 74.6]. Comparedto MEB, ALB was significantly more efficacious against hookworm (96.2% [91.1; 100], p,0.001) and only marginally,although significantly, better against A. lumbricoides infections (99.9% [99.0; 100], p = 0.012), but equally efficacious for T.trichiura infections (64.5% [44.4; 84.7], p = 0.906).Conclusions/Significance: A minimum FECR rate of 95% for A. lumbricoides, 70% for hookworm, and 50% for T. trichiura isexpected in MEB-dependent PC programs. Lower FECR results may indicate the development of potential drug resistance
Fil: Levecke, Bruno. University Of Ghent. Department of Virology, Parasitology and Immunology; Bélgica
Fil: Montresor, Antonio. World Health Organization. Department of Control of Neglected Tropical Diseases; Suiza
Fil: Albonico, Marco. Fondazione Ivo de Carneri; Italia
Fil: Ame, Shaali M.. Public Health Laboratory-Ivo De Carneri; Tanzania
Fil: Behnke, Jerzy M.. The University Of Nottingham; Reino Unido
Fil: Bethony, Jeffrey M.. The George Washington University; Estados Unidos
Fil: Noumedem, Calvine D.. University of Yaoundé; Camerún
Fil: Engels, Dirk. World Health Organization. Department of Control of Neglected Tropical Diseases; Suiza
Fil: Guillard, Bertrand. Pasteur Institute; Camboya
Fil: Kotze, Andrew. Commonwealth Scientific and Industrial Research Organisation; Australia
Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: McCarthy, James. The University Of Queensland; Australia
Fil: Mekonnen, Zeleke. Jimma University; Etiopía
Fil: Periago, Maria V.. Fundación Oswaldo Cruz. Instituto Rene Rachou; Brasil
Fil: Sopheak, Hem. Pasteur Institute; Camboya
Fil: Tchuem Tchuente, Louis Albert. University of Youndé; Camerún
Fil: Duong, Tran Thanh. National Institute of Malariology; Vietnam
Fil: Huong, Nguyen Thu. National Institute of Malariology; Vietnam
Fil: Zeynudin, Ahmed. Jimma University; Etiopía
Fil: Vercruysse, Jozef. University Of Ghent. Department of Virology, Parasitology and Immunology; Bélgica
Subject
MEBENDAZOL
TRICHURIS TRICHIURA
ASCARIS LUMBRICOIDES
HOOKWORM
Medicina Tropical
Ciencias de la Salud
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
License
https://creativecommons.org/licenses/by/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/7017