AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features

Authors
Rodig, Scott J.; Ouyang, Jing; Juszczynski, Przemyslaw; Currie, Treeve; Law, Kenneth; Neuberg, Donna S.; Rabinovich, Gabriel Adrián; Shipp, Margaret A.; Kutok, Jeffery L.
Publication Year
2008
Language
English
Format
article
Status
Published version
Description
Galectin-1 is an immunomodulatory glycan-binding protein regulated by an AP1-dependent enhancer in Hodgkin Reed-Sternberg cells. We recently found that Reed Sternberg cell Gal-1 promotes the immunosuppressive T helper2/ T-regulatory cell-skewed microenvironment in classic Hodgkin lymphoma (cHL). We sought to investigate whether the the coordinate expression of activated AP1 pathway components and Gal-1 serves as a diagnostic signature of cHL. In addition, because there are common signaling and survival pahtways in cHL and additional non-Hodgkin lymphomas, we also evaluated whether the AP1/Gal1 signature is shared by other molecularly or morphologically related lymhomas. Our findings establish a functional AP1 signature that incluses Gal-1 expression in cHL and ALCL, and suggests a common mechanmism for tumor immunotolerance in these diseases. In addition, the combination of Gal1 and c-Jun serve as diagnostic biomarkers that delineate cHL and ALCL from other lymphomas with shared morphologic and/or molecular features.
Fil: Rodig, Scott J.. Harvard Medical School; Estados Unidos
Fil: Ouyang, Jing. Dana Farber Cancer Institute; Estados Unidos
Fil: Juszczynski, Przemyslaw. Dana Farber Cancer Institute; Estados Unidos
Fil: Currie, Treeve. Harvard Medical School; Estados Unidos
Fil: Law, Kenneth. Harvard Medical School; Estados Unidos
Fil: Neuberg, Donna S.. Dana Farber Cancer Institute; Estados Unidos
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Shipp, Margaret A.. Dana Farber Cancer Institute; Estados Unidos
Fil: Kutok, Jeffery L.. Harvard Medical School; Estados Unidos
Subject
LYMPHOMAS
GALECTIN-1
AP-1
SIGNATURE
Bioquímica y Biología Molecular
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/25866