Autonomic nervous system activation during social cognition tasks in patients with schizophrenia and their unaffected relatives

Authors
Jáuregui, Ignacio Oscar; Costanzo, Elsa Y.; de Achaval, Delfina; Villarreal, Mirta Fabiana; Chu, Elvina; Mora, Martina C.; Vigo, Daniel Eduardo; Castro, Mariana Nair; Leiguarda, Ramón C.; Bär, Karl-Jürgen; Guinjoan, Salvador Martín
Publication Year
2011
Language
English
Format
article
Status
Published version
Description
Objective: To determine if patients with schizophrenia and their unaffected first degree relatives have abnormal autonomic nervous system (ANS) responses to social cognition tasks. Background: Social cognition impairments are significant in schizophrenia. ANS activity has been shown to be abnormal in schizophrenia patients, and some of these abnormalities seem to be shared by unaffected relatives of afflicted persons. Method: Heart rate variability (HRV) was measured at rest, and while performing social cognition tasks in patients with schizophrenia, their nonpsychotic firstdegree relatives, and matched healthy persons (n=19 in each group). Results: Social cognition tasks induced a shortening of the RR interval in unaffected relatives, but not in patients. Social cognition tasks generated decreases in high-frequency (HF, indicative of cardiac vagal activity) and in low frequency (LF, reflecting predominantly sympathetic activity) HRV in patients, while in relatives the decrease occurred in The HF component only. LF-HRV was higher in patients during a theory of mind task compared with a control task. These changes were not observed in healthy persons. Conclusions: Social cognitive tasks induce a pattern of peripheral autonomic activity different from that seen in generic arousal responses, and such pattern is abnormal in schizophrenia patients. Autonomic abnormalities in unaffected first degree relatives seem restricted to the parasympathetic division of the ANS.
Fil: Jáuregui, Ignacio Oscar. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Costanzo, Elsa Y.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: de Achaval, Delfina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villarreal, Mirta Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Chu, Elvina. University College London; Estados Unidos
Fil: Mora, Martina C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de Los Buenos Aires"; Argentina
Fil: Castro, Mariana Nair. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Leiguarda, Ramón C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Bär, Karl-Jürgen. Universitat Jena; Alemania
Fil: Guinjoan, Salvador Martín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina
Subject
Schizophrenia
Social Cognition
Autonomic Nervous System
Endophenotype
Neurociencias
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Psiquiatría
Medicina Clínica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/16382