Sleep and circadian rhythm dysregulation in schizophrenia

Authors
Monti, Jaime M.; BaHammam, Ahmed S.; Pandi-Perumal, Seithikurippu R.; Bromundt, Vivien; Spence, D. Warren; Cardinali, Daniel Pedro; Brown, Gregory M.
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
Sleep-onset and maintenance insomnia is a common symptom in schizophrenic patients regardless of either their medication status (drug-naive or previously treated) or the phase of the clinical course (acute or chronic). Regarding sleep architecture, the majority of studies indicate that non-rapid eye movement (NREM), N3 sleep and REM sleep onset latency are reduced in schizophrenia, whereas REM sleep duration tends to remain unchanged. Many of these sleep disturbances in schizophrenia appear to be caused by abnormalities of the circadian system as indicated by misalignments of the endogenous circadian cycle and the sleep–wake cycle. Circadian disruption, sleep onset insomnia and difficulties in maintaining sleep in schizophrenic patients could be partly related to a presumed hyperactivity of the dopaminergic system and dysfunction of the GABAergic system, both associated with core features of schizophrenia and with signaling in sleep and wake promoting brain regions. Since multiple neurotransmitter systems within the CNS can be implicated in sleep disturbances in schizophrenia, the characterization of the neurotransmitter systems involved remains a challenging dilemma.
Fil: Monti, Jaime M.. Hospital de Clínicas. Departamento de Farmacología y Terapéutica; Uruguay
Fil: BaHammam, Ahmed S.. King Saud University. University Sleep Disorders Center; Arabia Saudita
Fil: Pandi-Perumal, Seithikurippu R.. Somnogen Canada Inc.; Canadá
Fil: Bromundt, Vivien. University of Basel. Psychiatric Hospital. Centre for Chronobiology; Suiza
Fil: Spence, D. Warren.
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Brown, Gregory M.. University of Toronto. Centre for Addiction and Mental Health; Canadá
Subject
Circadian rhythms
Schizophrenia
Sleep
Psiquiatría
Medicina Clínica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/3858