Continuum theory of gene expression waves during vertebrate segmentation

Authors
Jörg, David J; Morelli, Luis Guillermo; Soroldoni, Daniele; Oates, Andrew C.; Jülicher, Frank
Publication Year
2015
Language
English
Format
article
Status
Published version
Description
The segmentation of the vertebrate body plan during embryonic development is a rhythmic and sequential process governed by genetic oscillations. These genetic oscillations give rise to traveling waves of gene expression in the segmenting tissue. Here we present a minimal continuum theory of vertebrate segmentation that captures the key principles governing the dynamic patterns of gene expression including the effects of shortening of the oscillating tissue. We show that our theory can quantitatively account for the key features of segmentation observed in zebrafish, in particular the shape of the wave patterns, the period of segmentation and the segment length as a function of time.
Fil: Jörg, David J. Max Planck Institute for the Physics of Complex Systems; Alemania
Fil: Morelli, Luis Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Soroldoni, Daniele. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Oates, Andrew C.. Francis Crick Institute, Mill Hill Laboratory; Alemania
Fil: Jülicher, Frank. Max Planck Institute for the Physics of Complex Systems; Alemania
Subject
BIOLOGICAL PHYSICS
GENE EXPRESSION WAVES
PATTERNING
EMBRYONIC DEVELOPMENT
Astronomía
Ciencias Físicas
CIENCIAS NATURALES Y EXACTAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/47686