Autophagy in Development, Cell Differentiation, and Homeodynamics: From Molecular Mechanisms to Diseases and Pathophysiology

Authors
Nezis, Ionnis P.; Vaccaro, Maria Ines; Devenish, Rodney J.; Juhász, Gábor
Publication Year
2014
Language
English
Format
article
Status
Published version
Description
The focus of this special issue is to highlight the role of autophagy in cellular homeodynamics, cell differentiation, and development with an outlook to diseases. Autophagy is an evolutionarily conserved catabolic process where cytoplasmic components are sequestered into double-membrane vesicles called autophagosomes, which then fuse with lysosomes and their content is degraded. Despite the significant progress observed over recent years in our understanding of the molecular mechanisms of autophagy, the elucidation of its role in developmental processes still remains a challenge for the scientific community. Given the role of autophagy in pathophysiology and diseases, it is essential to uncover how the mechanisms of autophagy function during developmental processes in the context of tissue and organismal physiology. This special issue contains a collection of four original research papers, four review articles, and one methodology report, covering a broad range of topics.
Fil: Nezis, Ionnis P.. University of Warwick; Reino Unido
Fil: Vaccaro, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Devenish, Rodney J.. Monash University; Australia
Fil: Juhász, Gábor. Eötvös University, Budapest; Argentina
Subject
Autophagy
Development
Cell differentiation
homeodynamics
Inmunología
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
License
https://creativecommons.org/licenses/by/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/30661