The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia

Authors
Perego, Ugo A.; Angerhofer, Norman; Pala, Maria; Olivieri, Anna; Lancioni, Hovirag; Kashani, Baharak Hooshiar; Carossa, Valeria; Ekins, Jayne E.; Gómez Carballa, Alberto; Huber, Gabriela; Zimmermann, Bettina; Corach, Daniel; Babudri, Nora; Panara, Fausto; Myres, Natalie M.; Parson, Walther; Semino, Ornella; Salas, Antonio; Woodward, Scott R.; Achilli, Alessandro; Torroni, Antonio
Publication Year
2010
Language
English
Format
article
Status
Published version
Description
Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo-Indians. In contrast, the estimated ages of C1d—the third subset of C1—looked too young to fit the above scenario. To define the origin of this enigmatic C1 branch, we completely sequenced 63 C1d mitochondrial genomes from a wide range of geographically diverse, mixed, and indigenous American populations. The revised phylogeny not only brings the age of C1d within the range of that of its two sister clades, but reveals that there were two C1d founder genomes for Paleo-Indians. Thus, the recognized maternal founding lineages of Native Americans are at least 15, indicating that the overall number of Beringian or Asian founder mitochondrial genomes will probably increase extensively when all Native American haplogroups reach the same level of phylogenetic and genomic resolution as obtained here for C1d.
Fil: Perego, Ugo A.. Soreson Molecular Genealogy Foundation; Estados Unidos. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Angerhofer, Norman. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Pala, Maria. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Olivieri, Anna. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Lancioni, Hovirag. Universita Di Perugia; Italia
Fil: Kashani, Baharak Hooshiar. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Carossa, Valeria. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Ekins, Jayne E.. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Gómez Carballa, Alberto. Universidad de Santiago de Compostela; España
Fil: Huber, Gabriela. Universidad de Innsbruck; Austria
Fil: Zimmermann, Bettina. Universidad de Innsbruck; Austria
Fil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Babudri, Nora. Universita Di Perugia; Italia
Fil: Panara, Fausto. Universita Di Perugia; Italia
Fil: Myres, Natalie M.. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Parson, Walther. Universidad de Innsbruck; Austria
Fil: Semino, Ornella. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Salas, Antonio. Universidad de Santiago de Compostela; España
Fil: Woodward, Scott R.. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Achilli, Alessandro. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia. Universita Di Perugia; Italia
Fil: Torroni, Antonio. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Subject
Pan-American mitochondrial DNA
Haplogroups
Medicina Forense
Otras Ciencias Médicas
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
License
https://creativecommons.org/licenses/by/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/14470