A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age

Authors
Mansilla, Eduardo; Roque, Gustavo; Sosa, Yolanda Elena; Tarditti, Adrian; Goya, Rodolfo Gustavo
Publication Year
2016
Language
English
Format
article
Status
Published version
Description
AbstractThere is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and the cells were administered every 2 weeks afterward. The treatment did not induce any obvious changes in body growth or behavior and the rat showed the typical age changes for this strain, except that, unlike intact counterparts, the animal did not develop mammary tumors or pituitary gland hyperplasia. The more remarkable effect of the treatment was on life span, which was 44 months compared with an average of 36 months for intact laboratory rats. We conclude that despite the low N value, it is likely that the MSC treatment was responsible for the exceptionally long survival of the rat. The potential rewards of confirming the present findings warrant further studies involving higher N values.
Fil: Mansilla, Eduardo. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; Argentina
Fil: Roque, Gustavo. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; Argentina
Fil: Sosa, Yolanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Tarditti, Adrian. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; Argentina
Fil: Goya, Rodolfo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Subject
mesenchymal stem cells
female rats
longevity
Otras Ciencias Biológicas
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/48858