Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling

Authors
Cardona Londoño, Juan Felipe; Gershanik, Oscar Samuel; Gelormini Lezama, Carlos; Lee Houck, Alexander; Cardona, Sebastián; Kargieman, Lucila; Trujillo, Natalia; Arévalo, Analía; Amoruso, Lucía; Manes, Facundo Francisco; Ibáñez Barassi, Agustín Mariano
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
Recent studies suggest that action-verb processing is particularly affected in early stage Parkinson´s disease (PD), highlighting the potential role of subcortical areas in language processing and in the semantic integration of actions. However, this disorder-related language impairment is frequently unrecognized by clinicians and often remains untreated. Early detection of action-language processing deficits could be critical for diagnosing and developing treatment strategies for PD. In this article, we review how action-verb processing is affected in PD and propose a model in which multiple and parallel frontotemporal circuits between the cortex and the basal ganglia provide the anatomic substrate for supporting action-language processing. We hypothesize that contextual coupling of action-language networks are partially dependent on cortical-subcortical integration, and not only on somatotopic motor cortical organization or in a mirror neuron system. This hypothesis is supported by both experimental and clinical evidence. Then, we identify further research steps that would help to determine the reliability of action-language impairments as an early marker of PD. Finally, theoretical implications for clinical assessment and for models of action-language interaction (action-perception cycle theories, mirror system models of language, and embodied cognition approaches to language) are discussed.
Fil: Cardona Londoño, Juan Felipe. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Universidad Favaloro; Argentina
Fil: Gershanik, Oscar Samuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina
Fil: Gelormini Lezama, Carlos. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Lee Houck, Alexander. University of Tennessee; Estados Unidos
Fil: Cardona, Sebastián. Universidad de Caldas; Colombia
Fil: Kargieman, Lucila. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Trujillo, Natalia. Universidad de Antioquía; Colombia
Fil: Arévalo, Analía. Universidad de la República; Uruguay
Fil: Amoruso, Lucía. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manes, Facundo Francisco. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina
Fil: Ibáñez Barassi, Agustín Mariano. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Subject
PARKINSON´S DISEASE
ACTION-VERB PROCESSING
BASAL GANGLIA
MOTOR-LANGUAGE COUPLING
MIRROR NEURONS
Reumatología
Medicina Clínica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/22828